Disease relevance of Cold Climate

• Hydrogen bonding between SA and polar regions of receptor protein, and the conformation on both imposed by it, would surely be changed by minor degrees of dehydration and substitution of alcohol molecules for water [1].
• Phage T7 and uracil biological dosimeters together with a Robertson-Berger (RB) meter have been used for monitoring environmental radiation from the polar region to the equator [2].
• Electron microscopy using immunogold labelling showed an apparent localization of cyclohexadienyl dehydratase at the polar regions of the periplasmic space in E. coli [3].

High impact information on Cold Climate

• The myosin B antibody reacts with the polar regions of all filaments but does not react with a central 0.9 micron zone [4].
• The observation of gullies on Mars indicates the presence of liquid water near the surface in recent times, which is difficult to reconcile with the current cold climate [5].
• The polar regions on Mars have distinctive morphologic and climatologic features: thick layered deposits, seasonal CO2 frost caps extending to mid latitudes, and near-polar residual frost deposits that survive the summer [6].
• Familial Mediterranean Fever in a cold climate: read The Lancet [7].
• Immunofluorescence studies show that the wild-type Asp protein is localized to the polar regions of the spindle immediately surrounding the centrosome [8].

Biological context of Cold Climate

• Conversely, local application of CD near the polar region caused inhibition of cytokinesis [9].
• Biogenesis of mitochondria 49 identification and mapping of a new mitochondrial locus (tsr1) which maps within polar region of yeast mitochondrial genome [10].
• However, laurylgallate and 15-pentadecanolide are also potent and selective inhibitors of cAK (IC50 values 1.5 and 20 microM, respectively) although the structures of both of these compounds involve a large non-polar portion associated with only one polar region [11].
• The second is a diaromatic patch on the A20 zinc finger, which binds with approximately 22-microM affinity to a polar region centered on Asp58 of ubiquitin [12].

Anatomical context of Cold Climate

• The interaction of botulinum neurotoxin serotypes A, B and E with membranes of different lipid compositions was examined by photolabelling with two photoreactive phosphatidylcholine analogues that monitor the polar region and the hydrophobic core of the lipid bilayer [13].
• In controls these regions and the polar region of intrafusal muscle fibers showed a rather clearer immunohistochemical dystrophin reaction than those of extrafusal muscle fibers with all antibodies used [14].
• There was increased fluidity of the polar regions of the plasma membrane and a decreased phosphatidylethanolamine/phosphatidylcholine ratio in A49 cells [15].
• Both perindoprilat and laser irradiation, when used separately, increase microviscosity in the polar region and hyperpolarize the membranes in comparison with control erythrocytes [16].
• The effect of cholesterol on vibrational spectra in the non polar and in the polar region of dimyristoyl phosphatidylserine (DMPS) and of phosphatidylserine from bovine spinal cord (PS) has been investigated [17].

Associations of Cold Climate with chemical compounds

• On the other hand, lipids with phosphoserine as the polar region, which has the "normal" P-N distance but carries a net negative charge, do not inhibit GT2p [18].
• The effects of net negative charge, of charge separation in phosphocholine, and of the distribution of charge in the polar region of lipids were studied using the GT2p isoform isolated from pig liver [18].
• The NH2 terminus of the cytochrome P-450 consists of five hydrophobic segments 18 to 23 residues long, separated by polar regions of 8 to 15 residues [19].
• In cortical regions, 5-HT transporters were concentrated to several limbic lobe structures (posterior uncus, entorhinal, cingulate, insular and temporal polar regions) [20].
• Cholesterol effects on the phosphatidylcholine bilayer polar region: a molecular simulation study [21].

Gene context of Cold Climate

• Resulting from the apparent use of a cryptic splice acceptor site in place of the canonical intron 5 site, this insertion is predicted to generate an in-frame insertion of five nonpolar amino acid residues within a highly polar region of the intracytoplasmic domain of the H-2K polypeptide [22].
• Since the first images of polar regions on Mars revealed alternating bright and dark layers, there has been speculation that their formation might be tied to the planet's orbital climate forcing [23].
• Our results show that mutations that remove two or more of the positively charged residues within the polar region no longer block membrane assembly of leader peptidase [24].
• The flexibility of the polar region in the TRbeta receptor, combined with differential recognition of the chemical group at the 1-carbon position, seems to stabilize the complex with GC-1 and contribute to its beta-selectivity [25].
• This occurs at the time of nuclear breakdown and eventually leads to an accumulation of the NuMA protein at the polar region of the mitotic spindle [26].

Analytical, diagnostic and therapeutic context of Cold Climate

• By determining the location of n-hexadecane droplets attached to cells by phase-contrast microscopy, the septal and polar regions of heated cells appeared to become the most frequently hydrophobic [27].

References