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MeSH Review

Cold Climate

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Disease relevance of Cold Climate


High impact information on Cold Climate

  • The myosin B antibody reacts with the polar regions of all filaments but does not react with a central 0.9 micron zone [4].
  • The observation of gullies on Mars indicates the presence of liquid water near the surface in recent times, which is difficult to reconcile with the current cold climate [5].
  • The polar regions on Mars have distinctive morphologic and climatologic features: thick layered deposits, seasonal CO2 frost caps extending to mid latitudes, and near-polar residual frost deposits that survive the summer [6].
  • Familial Mediterranean Fever in a cold climate: read The Lancet [7].
  • Immunofluorescence studies show that the wild-type Asp protein is localized to the polar regions of the spindle immediately surrounding the centrosome [8].

Biological context of Cold Climate


Anatomical context of Cold Climate


Associations of Cold Climate with chemical compounds

  • On the other hand, lipids with phosphoserine as the polar region, which has the "normal" P-N distance but carries a net negative charge, do not inhibit GT2p [18].
  • The effects of net negative charge, of charge separation in phosphocholine, and of the distribution of charge in the polar region of lipids were studied using the GT2p isoform isolated from pig liver [18].
  • The NH2 terminus of the cytochrome P-450 consists of five hydrophobic segments 18 to 23 residues long, separated by polar regions of 8 to 15 residues [19].
  • In cortical regions, 5-HT transporters were concentrated to several limbic lobe structures (posterior uncus, entorhinal, cingulate, insular and temporal polar regions) [20].
  • Cholesterol effects on the phosphatidylcholine bilayer polar region: a molecular simulation study [21].

Gene context of Cold Climate

  • Resulting from the apparent use of a cryptic splice acceptor site in place of the canonical intron 5 site, this insertion is predicted to generate an in-frame insertion of five nonpolar amino acid residues within a highly polar region of the intracytoplasmic domain of the H-2K polypeptide [22].
  • Since the first images of polar regions on Mars revealed alternating bright and dark layers, there has been speculation that their formation might be tied to the planet's orbital climate forcing [23].
  • Our results show that mutations that remove two or more of the positively charged residues within the polar region no longer block membrane assembly of leader peptidase [24].
  • The flexibility of the polar region in the TRbeta receptor, combined with differential recognition of the chemical group at the 1-carbon position, seems to stabilize the complex with GC-1 and contribute to its beta-selectivity [25].
  • This occurs at the time of nuclear breakdown and eventually leads to an accumulation of the NuMA protein at the polar region of the mitotic spindle [26].

Analytical, diagnostic and therapeutic context of Cold Climate


  1. Dehydration: a new alcohol theory. Klemm, W.R. Alcohol (1990) [Pubmed]
  2. The role of the spectral sensitivity curve in the selection of relevant biological dosimeters for solar UV monitoring. Modos, K., Gaspar, S., Kerekgyarto, T., Vink, A.A., Roza, L., Fekete, A. J. Photochem. Photobiol. B, Biol. (1999) [Pubmed]
  3. Cyclohexadienyl dehydratase from Pseudomonas aeruginosa is a periplasmic protein. Zhao, G., Xia, T., Aldrich, H., Jensen, R.A. J. Gen. Microbiol. (1993) [Pubmed]
  4. Differential localization of two myosins within nematode thick filaments. Miller, D.M., Ortiz, I., Berliner, G.C., Epstein, H.F. Cell (1983) [Pubmed]
  5. Formation of recent martian gullies through melting of extensive water-rich snow deposits. Christensen, P.R. Nature (2003) [Pubmed]
  6. North-south geological differences between the residual polar caps on Mars. Thomas, P.C., Malin, M.C., Edgett, K.S., Carr, M.H., Hartmann, W.K., Ingersoll, A.P., James, P.B., Soderblom, L.A., Veverka, J., Sullivan, R. Nature (2000) [Pubmed]
  7. Familial Mediterranean Fever in a cold climate: read The Lancet. Stewart, L., Tolmie, J., Galea, P., Touitou, I. Lancet (2000) [Pubmed]
  8. The Drosophila gene abnormal spindle encodes a novel microtubule-associated protein that associates with the polar regions of the mitotic spindle. Saunders, R.D., Avides, M.C., Howard, T., Gonzalez, C., Glover, D.M. J. Cell Biol. (1997) [Pubmed]
  9. Distinct roles of the equatorial and polar cortices in the cleavage of adherent cells. O'Connell, C.B., Warner, A.K., Wang, Y. Curr. Biol. (2001) [Pubmed]
  10. Biogenesis of mitochondria 49 identification and mapping of a new mitochondrial locus (tsr1) which maps within polar region of yeast mitochondrial genome. Devenish, R.J., Englisn, K.J., Hall, R.M., Linnase, A.W., Lukins, H.B. Mol. Gen. Genet. (1978) [Pubmed]
  11. Selective inhibition of cyclic AMP-dependent protein kinase by amphiphilic triterpenoids and related compounds. Wang, B.H., Polya, G.M. Phytochemistry (1996) [Pubmed]
  12. Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Lee, S., Tsai, Y.C., Mattera, R., Smith, W.J., Kostelansky, M.S., Weissman, A.M., Bonifacino, J.S., Hurley, J.H. Nat. Struct. Mol. Biol. (2006) [Pubmed]
  13. Effect of pH on the interaction of botulinum neurotoxins A, B and E with liposomes. Montecucco, C., Schiavo, G., Dasgupta, B.R. Biochem. J. (1989) [Pubmed]
  14. Dystrophin and a dystrophin-related protein in intrafusal muscle fibers, and neuromuscular and myotendinous junctions. Zhao, J., Yoshioka, K., Miyatake, M., Miike, T. Acta Neuropathol. (1992) [Pubmed]
  15. Effects of lipid supplementation of culture media on cell growth, antibody production, membrane structure and dynamics in two hybridomas. Savonnière, S., Zeghari, N., Miccoli, L., Muller, S., Maugras, M., Donner, M. J. Biotechnol. (1996) [Pubmed]
  16. Effect of combined treatment with perindoprilat and low-power red light laser irradiation on human erythrocyte membrane fluidity, membrane potential and acetylcholinesterase activity. Piasecka, A., Leyko, W., Krajewska, E., Bryszewska, M. Scand. J. Clin. Lab. Invest. (2000) [Pubmed]
  17. Fourier transform infrared spectroscopy of aqueous dispersions of phosphatidylserine-cholesterol mixtures. Brumfeld, V., Bach, D., Miller, I.R. Eur. Biophys. J. (1991) [Pubmed]
  18. The influence of charge and the distribution of charge in the polar region of phospholipids on the activity of UDP-glucuronosyltransferase. Zakim, D., Eibl, H. J. Biol. Chem. (1992) [Pubmed]
  19. The covalent structure of rabbit phenobarbital-induced cytochrome P-450. Partial amino acid sequence and order of cyanogen bromide peptides. Heinemann, F.S., Ozols, J. J. Biol. Chem. (1982) [Pubmed]
  20. Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Varnäs, K., Halldin, C., Hall, H. Human brain mapping. (2004) [Pubmed]
  21. Cholesterol effects on the phosphatidylcholine bilayer polar region: a molecular simulation study. Pasenkiewicz-Gierula, M., Róg, T., Kitamura, K., Kusumi, A. Biophys. J. (2000) [Pubmed]
  22. A novel H-2K splice form: predictions for other alternative H-2 splicing events. Vogel, J.M., Morse, R.Y., Goodenow, R.S. Immunogenetics (1989) [Pubmed]
  23. Orbital forcing of the martian polar layered deposits. Laskar, J., Levrard, B., Mustard, J.F. Nature (2002) [Pubmed]
  24. Positive charges in the cytoplasmic domain of Escherichia coli leader peptidase prevent an apolar domain from functioning as a signal. Laws, J.K., Dalbey, R.E. EMBO J. (1989) [Pubmed]
  25. Hormone selectivity in thyroid hormone receptors. Wagner, R.L., Huber, B.R., Shiau, A.K., Kelly, A., Cunha Lima, S.T., Scanlan, T.S., Apriletti, J.W., Baxter, J.D., West, B.L., Fletterick, R.J. Mol. Endocrinol. (2001) [Pubmed]
  26. Redistribution of the nuclear mitotic apparatus protein (NuMA) during mitosis and nuclear assembly. Properties of purified NuMA protein. Price, C.M., Pettijohn, D.E. Exp. Cell Res. (1986) [Pubmed]
  27. Destruction of the outer membrane permeability barrier of Escherichia coli by heat treatment. Tsuchido, T., Katsui, N., Takeuchi, A., Takano, M., Shibasaki, I. Appl. Environ. Microbiol. (1985) [Pubmed]
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