Disease relevance of SP5

• Lymphoblastoid cell lines "W" and "SP5" were established from splenectomy specimens of two patients with hairy cell leukemia [1].
• Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer [2].
• The SP5 combines the largest number of whole blood tests currently available in a rapid response instrument well-suited for care of the critically ill patient [3].

High impact information on SP5

• The SP 1 measures pH, pCO2, pO2, sodium, potassium, ionized calcium, and hematocrit in heparinized whole blood; the SP 5 determines all these analytes, plus chloride (not evaluated because it was unavailable at the time this study was initiated) and glucose [4].
• Continuous cultures of some of the subclones derived from cell line W and SP5 led to the growth of the cell lines W15T, W17T, and SP5T which all demonstrated T cell features based on immunophenotypic and T cell receptor rearrangement studies [1].
• The banding patterns of the rearranged Ig genes (heavy and light chains) in the W cell line were different and in the SP5 cell line were identical with the corresponding untransformed splenic cell lines, indicating that cell line SP5 did and cell line W did not represent the original neoplastic clone [1].
• SP4, SP5, and SP6 could be distinguished by changes in the orientation of the isovoltage contour lines and/or by changes in the location of the maximum [5].
• Stable period 1 (SP1: 58-90 msec post stimulus), SP4 (178-222 msec) and SP5 (223-277 msec) showed amplitude-stimulus intensity relationships that are similar to those of neurons involved in the sensory-discriminative aspects of innocuous somatosensation [6].

Biological context of SP5

• A glucose oxidase-H 2O 2 substrate-selective electrode (SSE) along with eight other electrodes allows the Stat Profile 5 (SP5) to measure glucose, electrolytes, blood gases, pH, and hematocrit simultaneously in whole blood [3].

References