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Gene Review

SP5  -  Sp5 transcription factor

Homo sapiens

Synonyms: Transcription factor Sp5
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Disease relevance of SP5


High impact information on SP5

  • The SP 1 measures pH, pCO2, pO2, sodium, potassium, ionized calcium, and hematocrit in heparinized whole blood; the SP 5 determines all these analytes, plus chloride (not evaluated because it was unavailable at the time this study was initiated) and glucose [4].
  • Continuous cultures of some of the subclones derived from cell line W and SP5 led to the growth of the cell lines W15T, W17T, and SP5T which all demonstrated T cell features based on immunophenotypic and T cell receptor rearrangement studies [1].
  • The banding patterns of the rearranged Ig genes (heavy and light chains) in the W cell line were different and in the SP5 cell line were identical with the corresponding untransformed splenic cell lines, indicating that cell line SP5 did and cell line W did not represent the original neoplastic clone [1].
  • SP4, SP5, and SP6 could be distinguished by changes in the orientation of the isovoltage contour lines and/or by changes in the location of the maximum [5].
  • Stable period 1 (SP1: 58-90 msec post stimulus), SP4 (178-222 msec) and SP5 (223-277 msec) showed amplitude-stimulus intensity relationships that are similar to those of neurons involved in the sensory-discriminative aspects of innocuous somatosensation [6].

Biological context of SP5

  • A glucose oxidase-H 2O 2 substrate-selective electrode (SSE) along with eight other electrodes allows the Stat Profile 5 (SP5) to measure glucose, electrolytes, blood gases, pH, and hematocrit simultaneously in whole blood [3].


  1. Use of deoxyribonucleic acid probes in the identification of cell origin and detection of cellular contamination in human lymphoblastoid cell lines. Naeim, F., Jensen, L., Susi, E., Yam, P., Gatti, R., Salser, W., Concannon, P. Lab. Invest. (1989) [Pubmed]
  2. Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer. Takahashi, M., Nakamura, Y., Obama, K., Furukawa, Y. Int. J. Oncol. (2005) [Pubmed]
  3. New whole blood methods and instruments: glucose measurement and test menus for critical care. Kost, G.J., Wiese, D.A., Bowen, T.P. Journal of the International Federation of Clinical Chemistry / IFCC. (1991) [Pubmed]
  4. Two whole-blood multi-analyte analyzers evaluated. Fleisher, M., Gladstone, M., Crystal, D., Schwartz, M.K. Clin. Chem. (1989) [Pubmed]
  5. SEP topographies elicited by innocuous and noxious sural nerve stimulation. I. Identification of stable periods and individual differences. Dowman, R. Electroencephalography and clinical neurophysiology. (1994) [Pubmed]
  6. SEP topographies elicited by innocuous and noxious sural nerve stimulation. II. Effects of stimulus intensity on topographic pattern and amplitude. Dowman, R. Electroencephalography and clinical neurophysiology. (1994) [Pubmed]
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