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Gene Review

SP1  -  Sp1 transcription factor

Homo sapiens

Synonyms: TSFP1, Transcription factor Sp1
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Disease relevance of SP1


Psychiatry related information on SP1


High impact information on SP1


Chemical compound and disease context of SP1


Biological context of SP1


Anatomical context of SP1


Associations of SP1 with chemical compounds


Physical interactions of SP1


Regulatory relationships of SP1


Other interactions of SP1


Analytical, diagnostic and therapeutic context of SP1


  1. Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer. Kaluz, S., Kaluzová, M., Stanbridge, E.J. Cancer Res. (2003) [Pubmed]
  2. Characterization of the MN/CA 9 promoter proximal region: a role for specificity protein (SP) and activator protein 1 (AP1) factors. Kaluzová, M., Pastoreková, S., Svastová, E., Pastorek, J., Stanbridge, E.J., Kaluz, S. Biochem. J. (2001) [Pubmed]
  3. Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: involvement of nuclear factor-kappaB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways. Kunz, M., Bloss, G., Gillitzer, R., Gross, G., Goebeler, M., Rapp, U.R., Ludwig, S. Biochem. J. (2002) [Pubmed]
  4. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. Katoh, Y., Katoh, M. Int. J. Oncol. (2007) [Pubmed]
  5. Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. Wei, D., Wang, L., He, Y., Xiong, H.Q., Abbruzzese, J.L., Xie, K. Cancer Res. (2004) [Pubmed]
  6. Abnormal Sp1 transcription factor expression in Alzheimer disease and tauopathies. Santpere, G., Nieto, M., Puig, B., Ferrer, I. Neurosci. Lett. (2006) [Pubmed]
  7. Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Courey, A.J., Holtzman, D.A., Jackson, S.P., Tjian, R. Cell (1989) [Pubmed]
  8. O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation. Jackson, S.P., Tjian, R. Cell (1988) [Pubmed]
  9. The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Dynan, W.S., Tjian, R. Cell (1983) [Pubmed]
  10. Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency. Almeida, A.M., Murakami, Y., Layton, D.M., Hillmen, P., Sellick, G.S., Maeda, Y., Richards, S., Patterson, S., Kotsianidis, I., Mollica, L., Crawford, D.H., Baker, A., Ferguson, M., Roberts, I., Houlston, R., Kinoshita, T., Karadimitris, A. Nat. Med. (2006) [Pubmed]
  11. The human placental lactogen genes: structure, function, evolution and transcriptional regulation. Walker, W.H., Fitzpatrick, S.L., Barrera-Saldaña, H.A., Resendez-Perez, D., Saunders, G.F. Endocr. Rev. (1991) [Pubmed]
  12. Prognostic factors in breast cancer: immunohistochemical staining for SP1 and NCRC 11 related to survival, tumour epidermal growth factor receptor and oestrogen receptor status. Wright, C., Angus, B., Napier, J., Wetherall, M., Udagawa, Y., Sainsbury, J.R., Johnston, S., Carpenter, F., Horne, C.H. J. Pathol. (1987) [Pubmed]
  13. Development of new rabbit monoclonal antibody to estrogen receptor: immunohistochemical assessment on formalin-fixed, paraffin-embedded tissue sections. Huang, Z., Zhu, W., Szekeres, G., Xia, H. Appl. Immunohistochem. Mol. Morphol. (2005) [Pubmed]
  14. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. Du, X.L., Edelstein, D., Dimmeler, S., Ju, Q., Sui, C., Brownlee, M. J. Clin. Invest. (2001) [Pubmed]
  15. Molecular cloning of cDNA for SPase, a monkey cathepsin L orthologue. Nishinaka, T., Song, J., Lum, K., Chiu, R. DNA Seq. (2005) [Pubmed]
  16. Cellular localization of AFP, hCG and its free subunits, and SP1 in embryonal carcinoma of the testis and ovary. Furumoto, M. Pathol. Res. Pract. (1981) [Pubmed]
  17. Erythroid-specific activity of the glycophorin B promoter requires GATA-1 mediated displacement of a repressor. Rahuel, C., Vinit, M.A., Lemarchandel, V., Cartron, J.P., Roméo, P.H. EMBO J. (1992) [Pubmed]
  18. 12-O-tetradecanoylphorbol-13-acetate activation of the MDR1 promoter is mediated by EGR1. McCoy, C., Smith, D.E., Cornwell, M.M. Mol. Cell. Biol. (1995) [Pubmed]
  19. Autoregulation of mouse histone deacetylase 1 expression. Schuettengruber, B., Simboeck, E., Khier, H., Seiser, C. Mol. Cell. Biol. (2003) [Pubmed]
  20. Identification of regulatory elements in the human adipose most abundant gene transcript-1 ( apM-1) promoter: role of SP1/SP3 and TNF-alpha as regulatory pathways. Barth, N., Langmann, T., Schölmerich, J., Schmitz, G., Schäffler, A. Diabetologia (2002) [Pubmed]
  21. Activation of AP-1 and SP1 correlates with wound growth factor gene expression in glucan-treated human fibroblasts. Wei, D., Williams, D., Browder, W. Int. Immunopharmacol. (2002) [Pubmed]
  22. Regulation of leukotriene C4 synthase gene expression by SP1 and SP3 in mononuclear phagocytes. Serio, K.J., Hodulik, C.R., Bigby, T.D. Adv. Exp. Med. Biol. (2002) [Pubmed]
  23. Induction of vascular endothelial growth factor by tumor necrosis factor alpha in human glioma cells. Possible roles of SP-1. Ryuto, M., Ono, M., Izumi, H., Yoshida, S., Weich, H.A., Kohno, K., Kuwano, M. J. Biol. Chem. (1996) [Pubmed]
  24. Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells. Zhang, W.J., Frei, B. Free Radic. Biol. Med. (2003) [Pubmed]
  25. Ligand- and cell-specific effects of signal transduction pathway inhibitors on progestin-induced vascular endothelial growth factor levels in human breast cancer cells. Wu, J., Brandt, S., Hyder, S.M. Mol. Endocrinol. (2005) [Pubmed]
  26. The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells. Zhu, G.H., Lenzi, M., Schwartz, E.L. Oncogene (2002) [Pubmed]
  27. Androgen induction of cyclin-dependent kinase inhibitor p21 gene: role of androgen receptor and transcription factor Sp1 complex. Lu, S., Jenster, G., Epner, D.E. Mol. Endocrinol. (2000) [Pubmed]
  28. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity. Mukhopadhyay, D., Knebelmann, B., Cohen, H.T., Ananth, S., Sukhatme, V.P. Mol. Cell. Biol. (1997) [Pubmed]
  29. The serotonin 1a receptor gene contains a TATA-less promoter that responds to MAZ and Sp1. Parks, C.L., Shenk, T. J. Biol. Chem. (1996) [Pubmed]
  30. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Wallerath, T., Deckert, G., Ternes, T., Anderson, H., Li, H., Witte, K., Förstermann, U. Circulation (2002) [Pubmed]
  31. The role of the transcription factor Sp1 in regulating the expression of the WAF1/CIP1 gene in U937 leukemic cells. Biggs, J.R., Kudlow, J.E., Kraft, A.S. J. Biol. Chem. (1996) [Pubmed]
  32. IL-4-induced oxidative stress upregulates VCAM-1 gene expression in human endothelial cells. Lee, Y.W., Kühn, H., Hennig, B., Neish, A.S., Toborek, M. J. Mol. Cell. Cardiol. (2001) [Pubmed]
  33. Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter. Gyrd-Hansen, M., Krag, T.O., Rosmarin, A.G., Khurana, T.S. J. Neurol. Sci. (2002) [Pubmed]
  34. The human caspase-8 promoter sustains basal activity through SP1 and ETS-like transcription factors and can be up-regulated by a p53-dependent mechanism. Liedtke, C., Groger, N., Manns, M.P., Trautwein, C. J. Biol. Chem. (2003) [Pubmed]
  35. Identification of a novel calcitonin-response element in the promoter of the human p21WAF1/CIP1 gene. Evdokiou, A., Raggatt, L.J., Sakai, T., Findlay, D.M. J. Mol. Endocrinol. (2000) [Pubmed]
  36. Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Zhang, L., Yu, D., Hu, M., Xiong, S., Lang, A., Ellis, L.M., Pollock, R.E. Cancer Res. (2000) [Pubmed]
  37. The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism. Whetstine, J.R., Witt, T.L., Matherly, L.H. J. Biol. Chem. (2002) [Pubmed]
  38. Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta. Pardali, K., Kurisaki, A., Morén, A., ten Dijke, P., Kardassis, D., Moustakas, A. J. Biol. Chem. (2000) [Pubmed]
  39. Molecular cloning and sequence analysis of the 5'-flanking region of the Sprague-Dawley rat thrombomodulin gene. Yao, A., Wang, J., Fink, L.M., Hardin, J.W., Hauer-Jensen, M. DNA Seq. (1999) [Pubmed]
  40. Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. Fujita, N., Kajita, M., Taysavang, P., Wade, P.A. Mol. Endocrinol. (2004) [Pubmed]
  41. Localization of the transcription factor SP1 gene to human chromosome 12q12-->q13.2. Gaynor, R.B., Shieh, B.H., Klisak, I., Sparkes, R.S., Lusis, A.J. Cytogenet. Cell Genet. (1993) [Pubmed]
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