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Gene Review

OR6B2  -  olfactory receptor, family 6, subfamily B,...

Homo sapiens

Synonyms: OR2-1, OR6B2P, Olfactory receptor 6B2, Olfactory receptor OR2-1
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Disease relevance of OR6B2

  • We propose that strains OR2 and LK6, together with the misclassified thermophilic strains Methylomonas gracilis VKM-14LT and Methylococcus thermophilus IMV-B3122, comprise a new genus of thermophilic methanotrophs, Methylocaldum gen. nov., containing three new species: Methylocaldum szegediense, Methylocaldum tepidum and Methylocaldum gracile [1].
  • High values of cholesterol were more frequently observed in patients with large adenomas than in controls (OR2 = 8.5, 95% CI 1.9-37.5; OR3 = 4.3, 95% CI 0.9-20.9) [2].

High impact information on OR6B2

  • As in the lambda chromosome, a region of the 434 chromosome, called the right operator, contains three repressor binding sites (OR1, OR2, and OR3) that mediate these effects on two adjacent promoters [3].
  • Thermotolerant strain LK6 was isolated from agricultural soil, and the moderately thermophilic strain OR2 was isolated from the effluent of an underground hot spring [1].
  • Adjusting for age, sex, race and education (OR2) and further adjusting for BMI, calories, sodium, smoking, vitamin C, fiber, alcohol, fat, and H. pylori status (OR3) did not yield significant results [4].
  • High values of cholesterol were associated with cancer risk (OR2 = 5.8, 95% CI 1.3-26.6; OR3 6.4, 95% CI 1.3-31.4) [2].
  • The six 434 operator sites (OR1, OR2, OR3, OL1, OL2 and OL3) have a particularly simple organization; all are 14 base pairs long, with a conserved 5'-ACAA sequence symmetrically placed at either end, and a variable central six base pairs [5].

Analytical, diagnostic and therapeutic context of OR6B2

  • The ratio number of labelled cells in the upper 40% of the crypt/total number of labelled cells (4h index) was found to be significantly higher only when the cancer group was compared to the control group: OR2 = 5.87 (1.33-25.90), OR3 = 9.48 (2.07-43.38), P for trend = 0.002 [6].
  • An additional 346 tracheotomies took place in the operating room in conjunction with other head and neck procedures (OR2) [7].


  1. Analysis of 16S rRNA and methane monooxygenase gene sequences reveals a novel group of thermotolerant and thermophilic methanotrophs, Methylocaldum gen. nov. Bodrossy, L., Holmes, E.M., Holmes, A.J., Kovács, K.L., Murrell, J.C. Arch. Microbiol. (1997) [Pubmed]
  2. Faecal neutral sterols and bile acids in patients with adenomas and large bowel cancer: an ECP case-control study. European cancer prevention. Roy, P., Owen, R.W., Faivre, J., Scheppach, W., Saldanha, M.H., Beckly, D.E., Boutron, M.C. Eur. J. Cancer Prev. (1999) [Pubmed]
  3. Activation of transcription by the bacteriophage 434 repressor. Bushman, F.D., Ptashne, M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. P53 Codon 72 polymorphisms: a case-control study of gastric cancer and potential interactions. Sul, J., Yu, G.P., Lu, Q.Y., Lu, M.L., Setiawan, V.W., Wang, M.R., Guo, C.H., Yu, S.Z., Mu, L., Cai, L., Kurtz, R.C., Zhang, Z.F. Cancer Lett. (2006) [Pubmed]
  5. The complex between phage 434 repressor DNA-binding domain and operator site OR3: structural differences between consensus and non-consensus half-sites. Rodgers, D.W., Harrison, S.C. Structure (1993) [Pubmed]
  6. Pattern of epithelial cell proliferation in colorectal mucosa of patients with large bowel adenoma or cancer: an ECP case-control study. European cancer prevention. Roy, P., Paganelli, G.M., Faivre, J., Biasco, G., Scheppach, W., Saldanha, M.H., Beckly, D.E. Eur. J. Cancer Prev. (1999) [Pubmed]
  7. The safety and efficacy of bedside tracheotomy. Futran, N.D., Dutcher, P.O., Roberts, J.K. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1993) [Pubmed]
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