Disease relevance of RGMA

• Dorsal root ganglion axons are unresponsive to RGM but are converted to a responsive state by neogenin expression [1].

High impact information on RGMA

• Recombinant RGM at low nanomolar concentration induces collapse of temporal but not of nasal growth cones and guides temporal retinal axons in vitro, demonstrating its repulsive and axon-specific guiding activity [2].
• Here we report the cloning and functional characterization of a membrane-associated glycoprotein, which we call RGM (repulsive guidance molecule) [2].
• Thus neogenin is a dependence receptor inducing cell death in the absence of RGM, whereas the presence of RGM inhibits this effect [3].
• To understand the functions of RGM-neogenin complexes in vivo, we used gene transfer technology to perturb their expression in the developing neural tube of chick embryos [3].
• The avoidance of chick RGM in the posterior optic tectum by growing temporal, but not nasal, retinal ganglion cell axons is thought to contribute to visual map formation [1].

Biological context of RGMA

• Surprisingly, neogenin over-expression or RGM down-expression in the neural tube induces apoptosis [3].
• Here, an expression cloning strategy identified neogenin as a binding site for RGM, with a sub-nanomolar affinity [1].

Anatomical context of RGMA

• Oxygen diffusion from medium to cultured isolated muscle fibers from red gastrocnemius muscle (deep part) (RGM) and white pectoralis muscle (WPM) of embryonic and postnatal chickens (about 6 months) was explored [4].

Physical interactions of RGMA

• Thus, RGM/neogenin is a novel dependence ligand/receptor couple as well as an axon guidance molecular complex [5].

References