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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Technology Transfer

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Disease relevance of Technology Transfer


High impact information on Technology Transfer

  • U2B: a new model for technology transfer [3].
  • This study highlights the need to understand more precisely the mechanism of action whereby monoclonal antibodies to ICAM-1 prolong cardiac allograft survival before new therapeutic strategies based on gene transfer technology or small molecule inhibitors are developed [4].
  • We have addressed the possible contribution of mitochondrial DNA (mtDNA) to the complex I deficiency in dystonia by the use of genome transfer technology [5].
  • These data suggest that BETA2/NeuroD protein transduction could be a safe and valuable strategy for enhancing insulin gene transcription without requiring gene transfer technology [6].
  • These data suggest that PDX-1 protein transduction could be a safe and valuable strategy for enhancing insulin gene transcription and for facilitating differentiation of ductal progenitor cells into insulin-producing cells without requiring gene transfer technology [7].

Biological context of Technology Transfer

  • METHODS: Adenovirus-mediated RAP gene transfer technology was used to evaluate the effect of prolonged overexpression of RAP on t-PA accumulation in conditioned medium of HMCs under basal and inflammatory conditions [8].

Associations of Technology Transfer with chemical compounds

  • This new technique may enable a wide application of liposome-mediated gene transfer technology not only to basic analysis of gene functions in the brain but also for clinical treatment of certain CNS disorders [9].
  • These results indicate that the functional properties of postsynaptic NMDA receptors can be manipulated by gene transfer technology using adenoviral vectors [10].
  • Since market size is needed for investment decisions that would allow technology transfer, the numbers of hypoxanthine analyses that are clinically justified from the extensive published evidence are calculated per million population from UK, Norwegian and other evidence [11].
  • Los Alamos rolls out technology transfer project for radiology [12].
  • The study also explores technology transfer issues associated with integrating the Matrix approach within existing treatment settings [13].

Gene context of Technology Transfer

  • In addition, we describe how new developments in gene transfer technology have added important tools to our arsenal for examining renin gene regulation and how these technologies can be used to develop new tools for renin and hypertension research [14].
  • Recent advances in gene transfer technology have enabled the expression of therapeutic to physiological levels of human FVIII in normal animals as well as hemophiliac mice and dogs [15].
  • Retroviral vectors carrying MDR1 as a selectable marker plus a second, heterologous gene of interest could have widespread utility for in vitro and in vivo applications of gene transfer technology, including gene therapy [16].
  • The Advanced Sensors Technology Transfer Programme (ASTTP) of the Department of Trade and Industry, stimulates and encourages the commercial exploitation of new sensor technology by UK industry [17].
  • These data suggest that PDX-1 protein transduction could be a safe and valuable strategy for facilitating differentiation of progenitor cells into insulin-producing cells without requiring gene transfer technology [18].


  1. Murine IL-10 gene transfer inhibits established collagen-induced arthritis and reduces adenovirus-mediated inflammatory responses in mouse liver. Quattrocchi, E., Dallman, M.J., Dhillon, A.P., Quaglia, A., Bagnato, G., Feldmann, M. J. Immunol. (2001) [Pubmed]
  2. Strengthening HIV prevention: application of a research-to-practice framework. Sogolow, E.D., Kay, L.S., Doll, L.S., Neumann, M.S., Mezoff, J.S., Eke, A.N., Semaan, S., Anderson, J.R. AIDS education and prevention : official publication of the International Society for AIDS Education. (2000) [Pubmed]
  3. U2B: a new model for technology transfer. Gross, C.M. Nat. Biotechnol. (2003) [Pubmed]
  4. Cardiac allograft survival in mice deficient in intercellular adhesion molecule-1. Schowengerdt, K.O., Zhu, J.Y., Stepkowski, S.M., Tu, Y., Entman, M.L., Ballantyne, C.M. Circulation (1995) [Pubmed]
  5. Mitochondrial DNA in focal dystonia: a cybrid analysis. Tabrizi, S.J., Cooper, J.M., Schapira, A.H. Ann. Neurol. (1998) [Pubmed]
  6. BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Noguchi, H., Bonner-Weir, S., Wei, F.Y., Matsushita, M., Matsumoto, S. Diabetes (2005) [Pubmed]
  7. PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Noguchi, H., Kaneto, H., Weir, G.C., Bonner-Weir, S. Diabetes (2003) [Pubmed]
  8. Adenovirus-mediated transfer of the 39 kD receptor-associated protein increases fibrinolytic capacity. Goedde, M.F., Grimbergen, J.M., Toet, K.H., Sitter, T., Quax, P.H., Kooistra, T. Kidney Int. (2001) [Pubmed]
  9. In vivo gene transfer into the adult mammalian central nervous system by continuous injection of plasmid DNA-cationic liposome complex. Imaoka, T., Date, I., Ohmoto, T., Yasuda, T., Tsuda, M. Brain Res. (1998) [Pubmed]
  10. Expression of recombinant NMDA receptors in hippocampal neurons by adenoviral-mediated gene transfer. Yamada, N., Sudo, M., Okado, H., Iino, M., Tsuzuki, K., Miwa, A., Ozawa, S. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  11. The importance of the measurement of ATP depletion and subsequent cell damage with an estimate of size and nature of the market for a practicable method: a review designed for technology transfer. Harkness, R.A., Saugstad, O.D. Scand. J. Clin. Lab. Invest. (1997) [Pubmed]
  12. Los Alamos rolls out technology transfer project for radiology. Dunbar, C. Health management technology. (1994) [Pubmed]
  13. A multisite study of the effectiveness of methamphetamine treatment: an initiative of the Center for Substance Abuse Treatment. Herrell, J.M., Taylor, J.A., Gallagher, C., Dawud-Noursi, S. Journal of psychoactive drugs. (2000) [Pubmed]
  14. Structure, expression, and regulation of the murine renin genes. Sigmund, C.D., Gross, K.W. Hypertension (1991) [Pubmed]
  15. Gene therapy for hemophilia A. Connelly, S., Kaleko, M. Thromb. Haemost. (1997) [Pubmed]
  16. Bicistronic and two-gene retroviral vectors for using MDR1 as a selectable marker and a therapeutic gene. Metz, M.Z., Matsumoto, L., Winters, K.A., Doroshow, J.H., Kane, S.E. Virology (1996) [Pubmed]
  17. Market requirements for advanced biosensors in healthcare. Owen, V.M. Biosensors & bioelectronics. (1994) [Pubmed]
  18. PDX-1 protein is internalized by lipid raft-dependent macropinocytosis. Noguchi, H., Matsumoto, S., Okitsu, T., Iwanaga, Y., Yonekawa, Y., Nagata, H., Matsushita, M., Wei, F.Y., Matsui, H., Minami, K., Seino, S., Masui, Y., Futaki, S., Tanaka, K. Cell transplantation. (2005) [Pubmed]
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