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Gene Review

NR1H3  -  nuclear receptor subfamily 1, group H,...

Gallus gallus

Synonyms: LXR, LXRA
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High impact information on NR1H3

  • Moreover, we observed that repression of the Coup-Tfs ablated the activation of Abca1, and Abcg1 mRNA expression by the selective LXR agonist, T0901317 [1].
  • Liver X receptor (LXR) agonists have been inferred to decrease cholesterol absorption through activation of ABCA1 expression [2].
  • In nuclear extracts from hepatocytes incubated in the absence of T3, ACCalpha-T3RE bound protein complexes (complexes 1 and 2) containing the liver X receptor (LXR) and the retinoid X receptor (RXR) [3].
  • We propose that complexes containing LXR/RXR ensure a basal level of ACCalpha expression for the synthesis of structural lipids in cell membranes and that complexes containing LXR/RXR and TR/RXR mediate the stimulation of ACCalpha expression caused by T3 [3].
  • Of two orphan nuclear receptors involved in cholesterol and bile acid homeostasis, only chicken liver X receptor (LXR) but not chicken farnesoid X receptor bound to the 240-bp PBRU [4].

Biological context of NR1H3

  • Our studies provide evidence that LXR/RXR mediate a fine regulation of cholesterol homeostasis in differentiating chondrocytes [5].
  • These results suggest that CYP2H1 induction is explained by the combined effect of multiple distal enhancer elements interacting with multiple transcription factors, including CXR and LXR [4].

Anatomical context of NR1H3


Associations of NR1H3 with chemical compounds

  • Furthermore, the expression of "classical" liver X receptor (LXR) target genes involved in reverse cholesterol transport (Abca1 and Abcg1) were both significantly repressed [1].


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