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Gene Review:

NR1H3 - nuclear receptor subfamily 1, group H,...

Gallus gallus

Synonyms: LXR, LXRA

Myers, S.A. et al., Zhang, Y. et al., Handschin, C. et al., Gentili, C. et al., Mulligan, J.D. et al., et al.

Myers, Wang, Muscat,

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High impact information on NR1H3

Moreover, we observed that repression of the Coup-Tfs ablated the activation of Abca1, and Abcg1 mRNA expression by the selective LXR agonist, T0901317 [1].
Liver X receptor (LXR) agonists have been inferred to decrease cholesterol absorption through activation of ABCA1 expression [2].
In nuclear extracts from hepatocytes incubated in the absence of T3, ACCalpha-T3RE bound protein complexes (complexes 1 and 2) containing the liver X receptor (LXR) and the retinoid X receptor (RXR) [3].
We propose that complexes containing LXR/RXR ensure a basal level of ACCalpha expression for the synthesis of structural lipids in cell membranes and that complexes containing LXR/RXR and TR/RXR mediate the stimulation of ACCalpha expression caused by T3 [3].
Of two orphan nuclear receptors involved in cholesterol and bile acid homeostasis, only chicken liver X receptor (LXR) but not chicken farnesoid X receptor bound to the 240-bp PBRU [4].

Biological context of NR1H3

Our studies provide evidence that LXR/RXR mediate a fine regulation of cholesterol homeostasis in differentiating chondrocytes [5].
These results suggest that CYP2H1 induction is explained by the combined effect of multiple distal enhancer elements interacting with multiple transcription factors, including CXR and LXR [4].

Anatomical context of NR1H3

Here, we investigate the mechanism by which the synthetic LXR agonist, T0-901317, increases the transcription of the acetyl-coenzyme A carboxylase-alpha (ACCalpha) gene in chick embryo hepatocyte cultures [6].
In differentiating chondrocytes, the expression of the liver X receptor (LXR) is modulated and its expression correlates to the expression of apoA-1 [5].

Associations of NR1H3 with chemical compounds

Furthermore, the expression of "classical" liver X receptor (LXR) target genes involved in reverse cholesterol transport (Abca1 and Abcg1) were both significantly repressed [1].

References

The chicken ovalbumin upstream promoter-transcription factors modulate genes and pathways involved in skeletal muscle cell metabolism. Myers, S.A., Wang, S.C., Muscat, G.E. J. Biol. Chem. (2006) [Pubmed]
ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens. Mulligan, J.D., Flowers, M.T., Tebon, A., Bitgood, J.J., Wellington, C., Hayden, M.R., Attie, A.D. J. Biol. Chem. (2003) [Pubmed]
Thyroid hormone stimulates acetyl-coA carboxylase-alpha transcription in hepatocytes by modulating the composition of nuclear receptor complexes bound to a thyroid hormone response element. Zhang, Y., Yin, L., Hillgartner, F.B. J. Biol. Chem. (2001) [Pubmed]
Multiple enhancer units mediate drug induction of CYP2H1 by xenobiotic-sensing orphan nuclear receptor chicken xenobiotic receptor. Handschin, C., Podvinec, M., Looser, R., Amherd, R., Meyer, U.A. Mol. Pharmacol. (2001) [Pubmed]
Cholesterol secretion and homeostasis in chondrocytes: a liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein A1 expression. Gentili, C., Tutolo, G., Pianezzi, A., Cancedda, R., Descalzi Cancedda, F. Matrix Biol. (2005) [Pubmed]
The mechanism mediating the activation of acetyl-coenzyme A carboxylase-{alpha} gene transcription by the liver X receptor agonist T0-901317. Talukdar, S., Hillgartner, F.B. J. Lipid Res. (2006) [Pubmed]

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