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Gene Review

Nr1h3  -  nuclear receptor subfamily 1, group H,...

Rattus norvegicus

Synonyms: Liver X receptor alpha, Lxra, Nuclear receptor subfamily 1 group H member 3, Oxysterols receptor LXR-alpha, RLD-1
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Disease relevance of Nr1h3


High impact information on Nr1h3


Biological context of Nr1h3


Anatomical context of Nr1h3

  • This regulation is not a direct effect of GH on hepatocytes and does not involve changed expression of SREBP-1c or LXRalpha mRNA but is associated with decreased insulin sensitivity [8].

Associations of Nr1h3 with chemical compounds

  • In addition, bile acid biosynthesis was inhibited despite the reduced expression of the small heterodimer partner (SHP) and activated LXRalpha, which also appeared to contribute to the accumulation of oxysterols followed by the acceleration of cholesterol efflux [1].
  • Oxysterols are potent regulators of the activities of transcription factors of the sterol regulatory element-binding protein family and of liver X-receptor alpha [9].
  • Although gemfibrozil induced mild effects on hepatic PPARalpha, HNF-4, and LXRalpha, only rosiglitazone significantly reduced plasma TG (59%), glucose (19%), insulin (61%), and leptin (66%), and liver TG (43%), CE (49%), and NEFA (27%) [10].
  • Clofibrate also enhanced the expression of mRNAs for PPARalpha, LXRalpha, and ABCA1 [11].
  • Clofibrate increased the levels of liver microsomal oxysterols including 25- and 27-hydroxycholesterol, which are potent activators of LXRalpha [11].

Analytical, diagnostic and therapeutic context of Nr1h3


  1. Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol. Hirayama, T., Honda, A., Matsuzaki, Y., Miyazaki, T., Ikegami, T., Doy, M., Xu, G., Lea, M., Salen, G. Hepatology (2006) [Pubmed]
  2. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Apfel, R., Benbrook, D., Lernhardt, E., Ortiz, M.A., Salbert, G., Pfahl, M. Mol. Cell. Biol. (1994) [Pubmed]
  3. Adipogenic transcriptional regulation of hepatic stellate cells. She, H., Xiong, S., Hazra, S., Tsukamoto, H. J. Biol. Chem. (2005) [Pubmed]
  4. The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression. Pawar, A., Botolin, D., Mangelsdorf, D.J., Jump, D.B. J. Biol. Chem. (2003) [Pubmed]
  5. Fetal epidermal differentiation and barrier development In vivo is accelerated by nuclear hormone receptor activators. Hanley, K., Kömüves, L.G., Bass, N.M., He, S.S., Jiang, Y., Crumrine, D., Appel, R., Friedman, M., Bettencourt, J., Min, K., Elias, P.M., Williams, M.L., Feingold, K.R. J. Invest. Dermatol. (1999) [Pubmed]
  6. Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses. Zhang, J., Lewis, R.M., Wang, C., Hales, N., Byrne, C.D. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
  7. Liver X receptors as potential therapeutic targets for multiple diseases. Cao, G., Liang, Y., Jiang, X.C., Eacho, P.I. Drug News Perspect. (2004) [Pubmed]
  8. Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver. Améen, C., Lindén, D., Larsson, B.M., Mode, A., Holmäng, A., Oscarsson, J. Am. J. Physiol. Endocrinol. Metab. (2004) [Pubmed]
  9. The role of cytochrome P450 in the regulation of cholesterol biosynthesis. Gibbons, G.F. Lipids (2002) [Pubmed]
  10. Different response of senescent female Sprague-Dawley rats to gemfibrozil and rosiglitazone administration. Sanguino, E., Roglans, N., Alegret, M., Sánchez, R.M., Vázquez-Carrera, M., Laguna, J.C. Exp. Gerontol. (2005) [Pubmed]
  11. Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. Guan, J.Z., Tamasawa, N., Murakami, H., Matsui, J., Yamato, K., Suda, T. Tohoku J. Exp. Med. (2003) [Pubmed]
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