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Gene Review

NR1H3  -  nuclear receptor subfamily 1, group H,...

Homo sapiens

Synonyms: LXR-a, LXRA, Liver X receptor alpha, Nuclear receptor subfamily 1 group H member 3, Oxysterols receptor LXR-alpha, ...
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Disease relevance of NR1H3


High impact information on NR1H3

  • These effects are likely due to enhanced expression of liver-x-receptor alpha, an oxysterol-activated nuclear receptor which induces ABCA1-promoter transcription [6].
  • In addition, LXR alpha increases cholesterol synthesis and release of nonesterified fatty acids [7].
  • Finally, treatment of mice with an LXR alpha agonist results in increased serum levels of glycerol and nonesterified fatty acids, consistent with increased lipolysis within adipose tissue [7].
  • Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism [7].
  • We demonstrate here that autoregulation of the LXR alpha gene is an important component of this lipid-inducible efflux pathway in human macrophages [8].

Chemical compound and disease context of NR1H3

  • In conclusion, these observations establish LXRalpha as a crucial regulator of bile acid glucuronidation in humans and suggest that accumulation of oxysterols in hepatocytes during cholestasis favors bile acid detoxification as glucuronide conjugates [9].

Biological context of NR1H3


Anatomical context of NR1H3


Associations of NR1H3 with chemical compounds


Physical interactions of NR1H3


Regulatory relationships of NR1H3


Other interactions of NR1H3


Analytical, diagnostic and therapeutic context of NR1H3


  1. Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol. Hirayama, T., Honda, A., Matsuzaki, Y., Miyazaki, T., Ikegami, T., Doy, M., Xu, G., Lea, M., Salen, G. Hepatology (2006) [Pubmed]
  2. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Auboeuf, D., Rieusset, J., Fajas, L., Vallier, P., Frering, V., Riou, J.P., Staels, B., Auwerx, J., Laville, M., Vidal, H. Diabetes (1997) [Pubmed]
  3. Identification of human low-density lipoprotein receptor as a novel target gene regulated by liver X receptor alpha. Ishimoto, K., Tachibana, K., Sumitomo, M., Omote, S., Hanano, I., Yamasaki, D., Watanabe, Y., Tanaka, T., Hamakubo, T., Sakai, J., Kodama, T., Doi, T. FEBS Lett. (2006) [Pubmed]
  4. Selective expression of cholesterol metabolism genes in normal CD34(+)CD38(-) cells with a heterogeneous expression pattern in AML cells. Peeters, S.D., van der Kolk, D.M., de Haan, G., Bystrykh, L., Kuipers, F., de Vries, E.G., Vellenga, E. Exp. Hematol. (2006) [Pubmed]
  5. Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages. Piraino, G., Cook, J.A., O'Connor, M., Hake, P.W., Burroughs, T.J., Teti, D., Zingarelli, B. Shock (2006) [Pubmed]
  6. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Chinetti, G., Lestavel, S., Bocher, V., Remaley, A.T., Neve, B., Torra, I.P., Teissier, E., Minnich, A., Jaye, M., Duverger, N., Brewer, H.B., Fruchart, J.C., Clavey, V., Staels, B. Nat. Med. (2001) [Pubmed]
  7. Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolism. Ross, S.E., Erickson, R.L., Gerin, I., DeRose, P.M., Bajnok, L., Longo, K.A., Misek, D.E., Kuick, R., Hanash, S.M., Atkins, K.B., Andresen, S.M., Nebb, H.I., Madsen, L., Kristiansen, K., MacDougald, O.A. Mol. Cell. Biol. (2002) [Pubmed]
  8. Autoregulation of the human liver X receptor alpha promoter. Laffitte, B.A., Joseph, S.B., Walczak, R., Pei, L., Wilpitz, D.C., Collins, J.L., Tontonoz, P. Mol. Cell. Biol. (2001) [Pubmed]
  9. The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Verreault, M., Senekeo-Effenberger, K., Trottier, J., Bonzo, J.A., Bélanger, J., Kaeding, J., Staels, B., Caron, P., Tukey, R.H., Barbier, O. Hepatology (2006) [Pubmed]
  10. Unliganded thyroid hormone receptor-beta1 represses liver X receptor alpha/oxysterol-dependent transactivation. Kawai, K., Sasaki, S., Morita, H., Ito, T., Suzuki, S., Misawa, H., Nakamura, H. Endocrinology (2004) [Pubmed]
  11. ABCA1 expression in carotid atherosclerotic plaques. Albrecht, C., Soumian, S., Amey, J.S., Sardini, A., Higgins, C.F., Davies, A.H., Gibbs, R.G. Stroke (2004) [Pubmed]
  12. Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. Downie, M.M., Sanders, D.A., Maier, L.M., Stock, D.M., Kealey, T. Br. J. Dermatol. (2004) [Pubmed]
  13. Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha. Goodwin, B., Watson, M.A., Kim, H., Miao, J., Kemper, J.K., Kliewer, S.A. Mol. Endocrinol. (2003) [Pubmed]
  14. Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator. Granlund, L., Juvet, L.K., Pedersen, J.I., Nebb, H.I. J. Lipid Res. (2003) [Pubmed]
  15. The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands. Färnegårdh, M., Bonn, T., Sun, S., Ljunggren, J., Ahola, H., Wilhelmsson, A., Gustafsson, J.A., Carlquist, M. J. Biol. Chem. (2003) [Pubmed]
  16. Trans geometric isomers of EPA decrease LXR{alpha}-induced cellular triacylglycerol via suppression of SREBP-1c and PGC-1{beta}. Zaima, N., Sugawara, T., Goto, D., Hirata, T. J. Lipid Res. (2006) [Pubmed]
  17. NO-1886 upregulates ATP binding cassette transporter A1 and inhibits diet-induced atherosclerosis in Chinese Bama minipigs. Zhang, C., Yin, W., Liao, D., Huang, L., Tang, C., Tsutsumi, K., Wang, Z., Liu, Y., Li, Q., Hou, H., Cai, M., Xiao, J. J. Lipid Res. (2006) [Pubmed]
  18. The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Brendel, C., Schoonjans, K., Botrugno, O.A., Treuter, E., Auwerx, J. Mol. Endocrinol. (2002) [Pubmed]
  19. Xol INXS: role of the liver X and the farnesol X receptors. Fayard, E., Schoonjans, K., Auwerx, J. Curr. Opin. Lipidol. (2001) [Pubmed]
  20. Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets. Viguerie, N., Vidal, H., Arner, P., Holst, C., Verdich, C., Avizou, S., Astrup, A., Saris, W.H., Macdonald, I.A., Klimcakova, E., Clément, K., Martinez, A., Hoffstedt, J., Sørensen, T.I., Langin, D. Diabetologia (2005) [Pubmed]
  21. TRRAP as a hepatic coactivator of LXR and FXR function. Unno, A., Takada, I., Takezawa, S., Oishi, H., Baba, A., Shimizu, T., Tokita, A., Yanagisawa, J., Kato, S. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  22. A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux. Sparrow, C.P., Baffic, J., Lam, M.H., Lund, E.G., Adams, A.D., Fu, X., Hayes, N., Jones, A.B., Macnaul, K.L., Ondeyka, J., Singh, S., Wang, J., Zhou, G., Moller, D.E., Wright, S.D., Menke, J.G. J. Biol. Chem. (2002) [Pubmed]
  23. Downregulated CD36 and oxLDL uptake and stimulated ABCA1/G1 and cholesterol efflux as anti-atherosclerotic mechanisms of interleukin-10. Rubic, T., Lorenz, R.L. Cardiovasc. Res. (2006) [Pubmed]
  24. Hypolipidemic effects of selective liver X receptor alpha agonists. Song, C., Liao, S. Steroids (2001) [Pubmed]
  25. Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity. Dahlman, I., Nilsson, M., Jiao, H., Hoffstedt, J., Lindgren, C.M., Humphreys, K., Kere, J., Gustafsson, J.A., Arner, P., Dahlman-Wright, K. Pharmacogenet. Genomics (2006) [Pubmed]
  26. Liver X receptor-alpha mediates cholesterol efflux in glomerular mesangial cells. Wu, J., Zhang, Y., Wang, N., Davis, L., Yang, G., Wang, X., Zhu, Y., Breyer, M.D., Guan, Y. Am. J. Physiol. Renal Physiol. (2004) [Pubmed]
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