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SERPINB10  -  serpin peptidase inhibitor, clade B...

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High impact information on MENT-1

  • Ectopic MENT expression in NIH 3T3 cells caused a large-scale and specific remodeling of chromatin marked by H3me2K9 [1].
  • We observed two sharp transitions of MENT concentration coinciding with the beta-globin boundary elements [1].
  • The MENT distribution profile was opposite to that of acetylated core histones but correlated with that of histone H3 dimethylated at lysine 9 (H3me2K9) [1].
  • Mutational analysis of MENT and experiments with deacetylase inhibitors revealed the essential role of the reaction center loop domain and an inhibitory affect of histone hyperacetylation on the MENT-induced chromatin remodeling in vivo [1].
  • Cryoelectron microscopy of chicken granulocyte chromatin, which is highly enriched with MENT, reveals exceptionally compact polynucleosomes, which maintain a level of higher order folding above that imposed by linker histones [2].
 

Biological context of MENT-1

  • We show that MENT is immunolocalized in granulocyte heterochromatin, where it is one of the most abundant chromatin proteins ( approximately 2 molecules/200 base pairs of DNA) [3].
  • The amino acid sequence of MENT reveals a close structural relationship with serpins, a large family of proteins known for their ability to undergo dramatic conformational transitions [2].
  • A novel nonhistone protein (MENT) promotes nuclear collapse at the terminal stage of avian erythropoiesis [4].
 

Anatomical context of MENT-1

  • One of them (42 kDa) is identified as MENT, a protein previously shown to be associated with repressed chromatin from mature chicken erythrocytes [3].
  • Chromatin structure in granulocytes. A link between tight compaction and accumulation of a heterochromatin-associated protein (MENT) [3].
  • MENT ectopically expressed in a mammalian cell line is transported into nuclei and is associated with intranuclear foci of condensed chromatin [2].
  • In vertebrate blood cells, these changes can be traced to the accumulation of a developmentally regulated heterochromatin protein, MENT [2].
  • One of the positively charged domains bears a significant similarity to the chromatin binding region of nuclear lamina proteins and with the A.T-rich DNA-binding motif, which may account for the targeting of MENT to peripheral heterochromatin [2].
 

Associations of MENT-1 with chemical compounds

  • MENT is the first nuclear protein structurally related to the serine protease inhibitor family [3].
 

Analytical, diagnostic and therapeutic context of MENT-1

References

  1. Insulation of the chicken beta-globin chromosomal domain from a chromatin-condensing protein, MENT. Istomina, N.E., Shushanov, S.S., Springhetti, E.M., Karpov, V.L., Krasheninnikov, I.A., Stevens, K., Zaret, K.S., Singh, P.B., Grigoryev, S.A. Mol. Cell. Biol. (2003) [Pubmed]
  2. MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member. Grigoryev, S.A., Bednar, J., Woodcock, C.L. J. Biol. Chem. (1999) [Pubmed]
  3. Chromatin structure in granulocytes. A link between tight compaction and accumulation of a heterochromatin-associated protein (MENT). Grigoryev, S.A., Woodcock, C.L. J. Biol. Chem. (1998) [Pubmed]
  4. A novel nonhistone protein (MENT) promotes nuclear collapse at the terminal stage of avian erythropoiesis. Grigoryev, S.A., Solovieva, V.O., Spirin, K.S., Krasheninnikov, I.A. Exp. Cell Res. (1992) [Pubmed]
  5. Stage-specific expression and localization of MENT, a nuclear protein associated with chromatin condensation in terminally differentiating avian erythroid cells. Grigoryev, S.A., Woodcock, C.L. Exp. Cell Res. (1993) [Pubmed]
 
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