Disease relevance of NEUROD1

• We used recombinant avian retroviruses to transfect green fluorescent protein (GFP) or NeuroD [1].

High impact information on NEUROD1

• In spinal cord and optic tectum, NeuroM expression precedes that of NeuroD [2].
• Ectopic expression of FGF10 in vivo promotes an increase in NeuroD and NeuroM expression [3].
• BrdU incorporation experiments showed that the increase in NeuroD-expressing cells is not due to an increase in cell proliferation [3].
• The gut supports neurogenic differentiation of periocular mesenchyme, a chondrogenic neural crest-derived cell population [4].
• Photoreceptor deficiency was evident even before the retina became laminated, suggesting that active repression of NeuroD may have affected photoreceptor genesis [5].

Biological context of NEUROD1

• We conclude that NeuroD stimulates cells from the toxin-damaged chicken retina to acquire some neuronal phenotypes [1].

Regulatory relationships of NEUROD1

• The number of calretinin-expressing cells that were generated was increased approximately 20-fold with forced expression of NeuroD [1].

Other interactions of NEUROD1

• Many cells transfected with the NeuroD-virus expressed calretinin, neurofilament, or visinin, while most cells remained undifferentiated [1].
• In addition, we found that cells transfected with NeuroD never expressed glutamine synthetase, a marker of mature Müller glia, suggesting that NeuroD suppresses glial differentiation [1].
• We conclude that for most tissues the expression of filaments of cytokeratin, vimentin, desmin, and neurofilament protein is mutually exclusive, and that these protein structurees provide useful markers for histochemical and cytochemical differentiation of cells of epithelial, mesenchymal, myogenic, and neurogenic differentiation [6].

Analytical, diagnostic and therapeutic context of NEUROD1

• In situ hybridization studies have been conducted, in conjunction with pulse-labeling of S-phase nuclei, to compare NeuroM to NeuroD expression in the developing nervous system [2].

References