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Gene Review

VIM  -  vimentin

Gallus gallus

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Disease relevance of VIM


High impact information on VIM

  • We have assessed the mechanism of intermediate filament assembly by assaying the sites of incorporation of chicken vimentin subunits expressed under the control of an inducible promoter in transfected mouse fibroblasts [3].
  • Additionally, a remarkable induction (40- to 50-fold) in the abundance of the vimentin mRNA is observed in erythroid cells as chicken development proceeds from 4 to 15 days, which suggests that the level of expression of vimentin during erythroid development is regulated at the transcriptional level [4].
  • We have isolated chicken cDNA and genomic clones for the intermediate filament subunit vimentin and show that the gene for this protein, which exists in a single copy in the haploid chicken genome, is transcribed into two mature mRNA species with approximate lengths of 2.0 and 2.3 kb [4].
  • Structural associations of synemin and vimentin filaments in avian erythrocytes revealed by immunoelectron microscopy [5].
  • Intermediate filaments containing vimentin and synemin form a three-dimensional network in these cells, interlinking the nucleus and plasma membrane [5].

Biological context of VIM


Anatomical context of VIM


Associations of VIM with chemical compounds


Regulatory relationships of VIM


Other interactions of VIM


Analytical, diagnostic and therapeutic context of VIM


  1. Expression of transfected vimentin genes in differentiating murine erythroleukemia cells reveals divergent cis-acting regulation of avian and mammalian vimentin sequences. Ngai, J., Bond, V.C., Wold, B.J., Lazarides, E. Mol. Cell. Biol. (1987) [Pubmed]
  2. Transient expression of an intermediate filament-associated protein (IFAPa-400) during in vivo and in vitro differentiation of chick embryonic cells derived from neuroectoderm. Chabot, P., Vincent, M. Brain Res. Dev. Brain Res. (1990) [Pubmed]
  3. Localization of newly synthesized vimentin subunits reveals a novel mechanism of intermediate filament assembly. Ngai, J., Coleman, T.R., Lazarides, E. Cell (1990) [Pubmed]
  4. Tissue-specific expression of two mRNA species transcribed from a single vimentin gene. Capetanaki, Y.G., Ngai, J., Flytzanis, C.N., Lazarides, E. Cell (1983) [Pubmed]
  5. Structural associations of synemin and vimentin filaments in avian erythrocytes revealed by immunoelectron microscopy. Granger, B.L., Lazarides, E. Cell (1982) [Pubmed]
  6. The chicken vimentin gene. Nucleotide sequence, regulatory elements, and comparison to the hamster gene. Zehner, Z.E., Li, Y., Roe, B.A., Paterson, B.M., Sax, C.M. J. Biol. Chem. (1987) [Pubmed]
  7. Desmin/vimentin intermediate filaments are dispensable for many aspects of myogenesis. Schultheiss, T., Lin, Z.X., Ishikawa, H., Zamir, I., Stoeckert, C.J., Holtzer, H. J. Cell Biol. (1991) [Pubmed]
  8. Phosphorylation of desmin in vitro inhibits formation of intermediate filaments; identification of three kinase A sites in the aminoterminal head domain. Geisler, N., Weber, K. EMBO J. (1988) [Pubmed]
  9. The amino acid sequence of chicken muscle desmin provides a common structural model for intermediate filament proteins. Geisler, N., Weber, K. EMBO J. (1982) [Pubmed]
  10. Overexpression of the vimentin gene in transgenic mice inhibits normal lens cell differentiation. Capetanaki, Y., Smith, S., Heath, J.P. J. Cell Biol. (1989) [Pubmed]
  11. Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton. Svitkina, T.M., Verkhovsky, A.B., Borisy, G.G. J. Cell Biol. (1996) [Pubmed]
  12. Desmin and vimentin coexist at the periphery of the myofibril Z disc. Granger, B.L., Lazarides, E. Cell (1979) [Pubmed]
  13. Canavanine inhibits vimentin assembly but not its synthesis in chicken embryo erythroid cells. Moon, R.T., Lazarides, E. J. Cell Biol. (1983) [Pubmed]
  14. In vitro translation of the intermediate filament proteins desmin and vimentin. O'Connor, C.M., Asai, D.J., Flytzanis, C.N., Lazarides, E. Mol. Cell. Biol. (1981) [Pubmed]
  15. Endogenous galectins and effect of galectin hapten inhibitors on the differentiation of the chick mesonephros. Murphy, K.M., Zalik, S.E. Dev. Dyn. (1999) [Pubmed]
  16. Persistence of an embryonic intermediate filament-associated protein in the smooth muscle cells of elastic arteries and in Purkinje fibres. Vincent, M., Levasseur, S., Currie, R.W., Rogers, P.A. J. Mol. Cell. Cardiol. (1991) [Pubmed]
  17. Modulation of tensin and vimentin expression in chick embryo developing cartilage and cultured differentiating chondrocytes. van de Werken, R., Gennari, M., Tavella, S., Bet, P., Molina, F., Lin, S., Cancedda, R., Castagnola, P. Eur. J. Biochem. (1993) [Pubmed]
  18. Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage. Fischer, A.J., Omar, G., Eubanks, J., McGuire, C.R., Dierks, B.D., Reh, T.A. Mol. Vis. (2004) [Pubmed]
  19. The origin of the subepicardial mesenchyme in the avian embryo: an immunohistochemical and quail-chick chimera study. Pérez-Pomares, J.M., Macías, D., García-Garrido, L., Muñoz-Chápuli, R. Dev. Biol. (1998) [Pubmed]
  20. Müller glia cells reorganize reaggregating chicken retinal cells into correctly laminated in vitro retinae. Willbold, E., Rothermel, A., Tomlinson, S., Layer, P.G. Glia (2000) [Pubmed]
  21. Intracellular localization of messenger RNAs for cytoskeletal proteins. Lawrence, J.B., Singer, R.H. Cell (1986) [Pubmed]
  22. Distributions of vimentin and desmin in developing chick myotubes in vivo. I. Immunofluorescence study. Tokuyasu, K.T., Maher, P.A., Singer, S.J. J. Cell Biol. (1984) [Pubmed]
  23. Vimentin filaments are assembled from a soluble precursor in avian erythroid cells. Blikstad, I., Lazarides, E. J. Cell Biol. (1983) [Pubmed]
  24. Immunocytochemical studies of endothelial cells in vivo. I. The presence of desmin only, or of desmin plus vimentin, or vimentin only, in the endothelial cells of different capillaries of the adult chicken. Fujimoto, T., Singer, S.J. J. Cell Biol. (1986) [Pubmed]
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