Disease relevance of LOC395914

• IFN-alpha (1 microg) or 10 microg of lymphotactin expressing plasmids, when given simultaneously with the pcDNA3-1E vaccine, significantly protected against body weight loss induced by E. acervulina [1].
• In particular, covaccination with EtMIC2 plus interleukin (IL)-8, IL-16, transforming growth factor-beta4, or lymphotactin significantly decreased oocyst shedding and improved weight gains beyond those achieved by EtMIC2 alone [2].

High impact information on LOC395914

• Identification of a chicken "C" chemokine related to lymphotactin [3].
• Parasite replication was significantly reduced in chickens given the pcDNA3-1E vaccine along with 10 microg of the IL-8, lymphotactin, IFN-gamma, IL-15, TGF-beta4, or IL-1beta plasmids compared with chickens given the pcDNA3-1E vaccine alone [1].
• Adjuvant effects of IL-1beta, IL-2, IL-8, IL-15, IFN-alpha, IFN-gamma TGF-beta4 and lymphotactin on DNA vaccination against Eimeria acervulina [1].
• It is suggested, therefore, that MG infection of the embryonic membranes causes the embryos to secrete lymphotactin, which induces the migration and accumulation of lymphocytes to the sites of infection [4].

Anatomical context of LOC395914

• Immunolabelling of MG-infected membranes showed a massive infiltration of lymphocytes possessing CD3 surface markers and the presence of cells that secreted lymphotactin, a chemokine [4].

References