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Gene Review

IL16  -  interleukin 16

Gallus gallus

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Disease relevance of IL16

  • In particular, covaccination with EtMIC2 plus interleukin (IL)-8, IL-16, transforming growth factor-beta4, or lymphotactin significantly decreased oocyst shedding and improved weight gains beyond those achieved by EtMIC2 alone [1].

High impact information on IL16

  • A recombinant protein containing the 149 C-terminal amino acids of pro-IL-16, expressed in COS-7 cells, showed chemoattractant activity for splenic lymphocytes [2].
  • By Northern blot analysis, IL-16 transcripts were identified in chicken lymphoid tissues but none of the non-lymphoid tissues examined [2].
  • Interleukin-16 is an inflammatory cytokine synthesized as a precursor protein (pro-IL-16) [2].
  • When lymphocyte subpopulations were similarly analyzed, IFN-gamma, IL-2, IL-3, IL-15, and MIF were most highly increased in TCR2(+) cells following E. acervulina infection, while TCR1(+) cells only expressed high levels of IL-16 following E. tenella infection [3].

Biological context of IL16


  1. Embryo vaccination against Eimeria tenella and E. acervulina infections using recombinant proteins and cytokine adjuvants. Lillehoj, H.S., Ding, X., Dalloul, R.A., Sato, T., Yasuda, A., Lillehoj, E.P. J. Parasitol. (2005) [Pubmed]
  2. Identification and characterization of chicken interleukin-16 cDNA. Min, W., Lillehoj, H.S. Dev. Comp. Immunol. (2004) [Pubmed]
  3. Analysis of chicken cytokine and chemokine gene expression following Eimeria acervulina and Eimeria tenella infections. Hong, Y.H., Lillehoj, H.S., Lee, S.H., Dalloul, R.A., Lillehoj, E.P. Vet. Immunol. Immunopathol. (2006) [Pubmed]
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