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Gene Review

STMN2  -  stathmin-like 2

Gallus gallus

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High impact information on STMN2

  • SCG10, a pan-neuronal membrane protein, is first detected one stage later, followed by the catecholaminergic neurotransmitter enzyme tyrosine hydroxylase (TH) [1].
  • Regulation of the 2 kb messenger RNA, but not the 1 kb messenger RNA, is dependent on the differentiation of PC12 cells, indicating that post-transcriptional regulation of SCG10 expression during neurite outgrowth [2].
  • In PC12 cells, the two SCG10 messenger RNAs were shown to be differentially induced by nerve growth factor [2].
  • The directed transport and positional translation of SCG10 messenger RNA provide a potential mechanism for protein targeting and the creation of molecular compartments during neuronal differentiation [2].
  • We have investigated the temporal and spatial regulation of SCG10 gene expression during neuronal differentiation [2].

Anatomical context of STMN2

  • This study demonstrates both temporal and spatial post-transcriptional regulation of SCG10 expression which is associated with neurite outgrowth [2].
  • RNA encoding SCG10, a pan-neuronal marker like NF-M, is strongly expressed throughout adrenal anlagen during E6 but is found at reduced levels in chromaffin cells compared with neuronal cells at E15 [3].

Analytical, diagnostic and therapeutic context of STMN2


  1. Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons. Groves, A.K., George, K.M., Tissier-Seta, J.P., Engel, J.D., Brunet, J.F., Anderson, D.J. Development (1995) [Pubmed]
  2. Differential induction and intracellular localization of SCG10 messenger RNA is associated with neuronal differentiation. Hannan, A.J., Henke, R.C., Weinberger, R.P., Sentry, J.W., Jeffrey, P.L. Neuroscience (1996) [Pubmed]
  3. Expression of neuronal markers suggests heterogeneity of chick sympathoadrenal cells prior to invasion of the adrenal anlagen. Ernsberger, U., Esposito, L., Partimo, S., Huber, K., Franke, A., Bixby, J.L., Kalcheim, C., Unsicker, K. Cell Tissue Res. (2005) [Pubmed]
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