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Gene Review

STMN2  -  stathmin 2

Homo sapiens

Synonyms: Protein SCG10, SCG10, SCGN10, Stathmin-2, Superior cervical ganglion-10 protein
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Disease relevance of STMN2


Psychiatry related information on STMN2


High impact information on STMN2

  • Our results indicate that TRPC5 channel subunits interact with the growth cone-enriched protein stathmin 2, are packaged into vesicles and are carried to newly forming growth cones and synapses [6].
  • JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length [7].
  • SCG10-S73 phosphorylation is significantly decreased in JNK1-/- cortex, indicating that JNK1 phosphorylates SCG10 in developing forebrain [7].
  • These data suggest that JNK1 is responsible for regulation of SCG10 depolymerizing activity and neurite elongation during brain development [7].
  • The NGF induction of SCG10 mRNA was mimicked only by activated Src and Ras and was blocked by p21N17 Ras, while the induction of Thy-1 mRNA was mimicked only by activated Src and was not blocked by p21N17 Ras [8].

Biological context of STMN2


Anatomical context of STMN2


Associations of STMN2 with chemical compounds


Physical interactions of STMN2


Regulatory relationships of STMN2

  • Using northern blot and in situ hybridization, we revealed that: (i) silencing retinal activity with tetrodotoxin eye injections dynamically reduced the expression of SCG10 mRNA and (ii) it was enhanced by BDNF in VC and LGN of kittens but not adult cats [18].
  • Conversely, Mash1 induces neuronal differentiation characterized by the expression of generic neuronal genes SCG10, Hu and NF160; however, only a subpopulation of these neurons also displays an autonomic, noradrenergic phenotype [19].

Other interactions of STMN2


Analytical, diagnostic and therapeutic context of STMN2


  1. STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells. Lee, H.S., Lee, D.C., Park, M.H., Yang, S.J., Lee, J.J., Kim, D.M., Jang, Y., Lee, J.H., Choi, J.Y., Kang, Y.K., Kim, D.I., Park, K.C., Kim, S.Y., Yoo, H.S., Choi, E.J., Yeom, Y.I. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  2. Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10. Antonsson, B., Lütjens, R., Di Paolo, G., Kassel, D., Allet, B., Bernard, A., Catsicas, S., Grenningloh, G. Protein Expr. Purif. (1997) [Pubmed]
  3. Olf/EBF proteins are expressed in neuroblastoma cells: potential regulators of the Chromogranin A and SCG10 promoters. Persson, P., Manetopoulos, C., Lagergren, A., Nygren, J., Gisler, R., Axelson, H., Sigvardsson, M. Int. J. Cancer (2004) [Pubmed]
  4. The control of microtubule stability in vitro and in transfected cells by MAP1B and SCG10. Bondallaz, P., Barbier, A., Soehrman, S., Grenningloh, G., Riederer, B.M. Cell Motil. Cytoskeleton (2006) [Pubmed]
  5. SCG10, a neuron-specific growth-associated protein in Alzheimer's disease. Okazaki, T., Wang, H., Masliah, E., Cao, M., Johnson, S.A., Sundsmo, M., Saitoh, T., Mori, N. Neurobiol. Aging (1995) [Pubmed]
  6. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Greka, A., Navarro, B., Oancea, E., Duggan, A., Clapham, D.E. Nat. Neurosci. (2003) [Pubmed]
  7. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. Tararuk, T., Ostman, N., Li, W., Björkblom, B., Padzik, A., Zdrojewska, J., Hongisto, V., Herdegen, T., Konopka, W., Courtney, M.J., Coffey, E.T. J. Cell Biol. (2006) [Pubmed]
  8. A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions. D'Arcangelo, G., Halegoua, S. Mol. Cell. Biol. (1993) [Pubmed]
  9. Biological activity and modular structure of RE-1-silencing transcription factor (REST), a repressor of neuronal genes. Thiel, G., Lietz, M., Cramer, M. J. Biol. Chem. (1998) [Pubmed]
  10. The "SCG10-LIke Protein" SCLIP is a novel regulator of axonal branching in hippocampal neurons, unlike SCG10. Poulain, F.E., Sobel, A. Mol. Cell. Neurosci. (2007) [Pubmed]
  11. Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity. Antonsson, B., Kassel, D.B., Di Paolo, G., Lutjens, R., Riederer, B.M., Grenningloh, G. J. Biol. Chem. (1998) [Pubmed]
  12. RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6. Liu, Z., Chatterjee, T.K., Fisher, R.A. J. Biol. Chem. (2002) [Pubmed]
  13. Analysis of the regulation of microtubule dynamics by interaction of RGSZ1 (RGS20) with the neuronal stathmin, SCG10. Nixon, A.B., Casey, P.J. Meth. Enzymol. (2004) [Pubmed]
  14. SCG10, a microtubule destabilizing factor, stimulates the neurite outgrowth by modulating microtubule dynamics in rat hippocampal primary cultured neurons. Morii, H., Shiraishi-Yamaguchi, Y., Mori, N. J. Neurobiol. (2006) [Pubmed]
  15. Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region. Di Paolo, G., Lutjens, R., Pellier, V., Stimpson, S.A., Beuchat, M.H., Catsicas, S., Grenningloh, G. J. Biol. Chem. (1997) [Pubmed]
  16. Taxol and tau overexpression induced calpain-dependent degradation of the microtubule-destabilizing protein SCG10. Vega, I.E., Hamano, T., Propost, J.A., Grenningloh, G., Yen, S.H. Exp. Neurol. (2006) [Pubmed]
  17. Site-specific phosphorylation of SCG10 in neuronal plasticity: role of Ser73 phosphorylation by N-methyl D-aspartic acid receptor activation in rat hippocampus. Morii, H., Yamada, T., Nakano, I., Coulson, J.M., Mori, N. Neurosci. Lett. (2006) [Pubmed]
  18. Brain-derived neurotrophic factor enhances expression of superior cervical ganglia clone 10 in lateral geniculate nucleus and visual cortex of developing kittens. Imamura, K., Morii, H., Nakadate, K., Yamada, T., Mataga, N., Watanabe, Y., Mori, N. Eur. J. Neurosci. (2006) [Pubmed]
  19. Interaction of Mash1 and Phox2b in sympathetic neuron development. Stanke, M., Stubbusch, J., Rohrer, H. Mol. Cell. Neurosci. (2004) [Pubmed]
  20. Transcription factor REST dependent proteins are comparable between Down syndrome and control brains: challenging a hypothesis. Sohn, S.Y., Weitzdoerfer, R., Mori, N., Lubec, G. J. Neural Transm. Suppl. (2003) [Pubmed]
  21. K252a potentiates epidermal growth factor-induced differentiation of PC12 cells. Wu, C.F., Zhang, M., Howard, B.D. J. Neurosci. Res. (1993) [Pubmed]
  22. Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles. Lutjens, R., Igarashi, M., Pellier, V., Blasey, H., Di Paolo, G., Ruchti, E., Pfulg, C., Staple, J.K., Catsicas, S., Grenningloh, G. Eur. J. Neurosci. (2000) [Pubmed]
  23. Double-blind comparison of the protective effect of sodium cromoglycate and ketotifen on exercise-induced asthma in adults. Tan, W.C., Lim, T.K. Allergy (1987) [Pubmed]
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