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Gene Review

Stmn2  -  stathmin-like 2

Mus musculus

Synonyms: AI159727, Protein SCG10, SCG10, Scg10, Scgn10, ...
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Disease relevance of Stmn2

  • To explore the structural and evolutionary relationships between these genes, we have isolated a series of cosmid and phage clones that covers the entire region of the mouse stathmin gene and most of the mouse SCG10 gene [1].

High impact information on Stmn2

  • Differentiation of this precursor to neurons that express markers such as SCG10, peripherin, and neuron-specific enolase is dependent upon MASH1 function [2].
  • We have localized a cell type-specific silencer element in the SCG10 gene by deletion analysis [3].
  • Deletion of the 5'-most 3.7 kb of SCG10 sequence yields deregulated expression of the transgene in numerous nonneuronal tissues, although expression remains highest in brain [4].
  • A low level of expression is detected in adrenal gland as well, consistent with the behavior of endogenous SCG10 [4].
  • SCG10 is a neural-specific, growth-associated protein that is broadly expressed in the embryonic central and peripheral nervous systems [4].

Biological context of Stmn2


Anatomical context of Stmn2

  • Analysis of sensory neurons which strongly express NSCL-1 revealed that the spatiotemporal expression of neuronal differentiation factors, such as NeuroD and SCG-10, was not altered in developing distal and proximal cranial ganglia of mutant mice [8].
  • As a first step to understanding the signaling mechanisms downstream of Pcdhgamma, we identify the microtubule-destabilizing protein SCG10 as a cytoplasmic interactor for Pcdhgamma-b1 and other isoforms of the Pcdhgamma-b subfamily, and show that SCG10 and Pcdhgamma-b1 are found together in certain neuronal growth cones [9].
  • SCG10 mRNA localization in the hippocampus: comparison with other mRNAs encoding neuronal growth-associated proteins (nGAPs) [10].
  • SCG10 mRNA is not detectable in the dentate gyrus of the mouse hippocampus, although it is expressed in the rat dentate gyrus [10].
  • In the mouse, SCG10 mRNA is expressed at high levels in pyramidal cells of CA3-CA4 sub-fields of Ammon's horn and at low levels in the CA1-CA2 sub-fields, while it is found rather uniformly throughout the pyramidal cell layer of the rat hippocampus [10].

Regulatory relationships of Stmn2

  • These data are consistent with the idea that the neuron-specific SCG10 gene evolved by duplication and modification of the more broadly expressed stathmin/Lap18 gene [1].

Other interactions of Stmn2

  • Molecular diversity of the SCG10/stathmin gene family in the mouse [1].
  • After regeneration in the adult following peripheral lesion of the olfactory epithelium, stathmin and SCG10 were again strongly expressed and generally colocalized with neuronal specific tubulin immunoreactivity [6].

Analytical, diagnostic and therapeutic context of Stmn2

  • During the post-implantation period, SCG10 transcripts were only detected in the uterus and placenta by reverse transcriptase-PCR, whereas p19 mRNA could be detected by Northern blotting and showed stage-specific expression in both tissues [7].


  1. Molecular diversity of the SCG10/stathmin gene family in the mouse. Okazaki, T., Yoshida, B.N., Avraham, K.B., Wang, H., Wuenschell, C.W., Jenkins, N.A., Copeland, N.G., Anderson, D.J., Mori, N. Genomics (1993) [Pubmed]
  2. The cellular function of MASH1 in autonomic neurogenesis. Sommer, L., Shah, N., Rao, M., Anderson, D.J. Neuron (1995) [Pubmed]
  3. A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells. Mori, N., Schoenherr, C., Vandenbergh, D.J., Anderson, D.J. Neuron (1992) [Pubmed]
  4. Analysis of SCG10 gene expression in transgenic mice reveals that neural specificity is achieved through selective derepression. Wuenschell, C.W., Mori, N., Anderson, D.J. Neuron (1990) [Pubmed]
  5. Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation. Schubart, U.K., Yu, J., Amat, J.A., Wang, Z., Hoffmann, M.K., Edelmann, W. J. Biol. Chem. (1996) [Pubmed]
  6. Expression of stathmin and SCG10 proteins in the olfactory neurogenesis during development and after lesion in the adulthood. Camoletto, P., Colesanti, A., Ozon, S., Sobel, A., Fasolo, A. Brain Res. Bull. (2001) [Pubmed]
  7. Differential mRNA expression of the phosphoprotein p19/SCG10 gene family in mouse preimplantation embryos, uterus, and placenta. Pampfer, S., Fan, W., Schubart, U.K., Pollard, J.W. Reprod. Fertil. Dev. (1992) [Pubmed]
  8. The neuronal basic helix-loop-helix transcription factor NSCL-1 is dispensable for normal neuronal development. Krüger, M., Braun, T. Mol. Cell. Biol. (2002) [Pubmed]
  9. The b1 isoform of protocadherin-gamma (Pcdhgamma) interacts with the microtubule-destabilizing protein SCG10. Gayet, O., Labella, V., Henderson, C.E., Kallenbach, S. FEBS Lett. (2004) [Pubmed]
  10. SCG10 mRNA localization in the hippocampus: comparison with other mRNAs encoding neuronal growth-associated proteins (nGAPs). Himi, T., Okazaki, T., Mori, N. Brain Res. (1994) [Pubmed]
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