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Gene Review

RPS6  -  ribosomal protein S6

Gallus gallus

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Disease relevance of RPS6


High impact information on RPS6


Biological context of RPS6

  • The sequence encoding the histone-like C-terminal extension was contiguous with upstream coding sequence within a single open reading frame in Exon 3, indicating that the lysine-rich extension in mosquito RPS6 is not the result of an aberrant splicing event [7].
  • The addition of phorbol 12-myristate 13-acetate (PMA), a potent tumor promoter, to serum-starved quiescent chicken embryo fibroblasts (CEF) or C127 murine cells resulted in increased phosphorylation of 40S ribosomal protein S6 [3].

Associations of RPS6 with chemical compounds

  • The additional sequence encodes a 100-amino acid, lysine-rich C-terminal extension of the RPS6 protein with 42-49% identity to histone H1 proteins from the chicken and other multicellular organisms [7].
  • Protein kinase capable of phosphorylating 40S ribosomal protein S6 on serine residues has been detected in chicken embryo fibroblasts [1].


  1. Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma virus transforming protein, serum, or phorbol ester. Blenis, J., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  2. Increase in ribosomal protein S6 phosphorylation is due to v-erbB-transforming activity and not to v-erbA mitogenic activity in avian erythroblastosis virus-infected chicken embryo fibroblasts. Diaz, J.J., Gandrillon, O., Hentzen, D., Leguellec, D., Samarut, J., Madjar, J.J. Oncogene Res. (1989) [Pubmed]
  3. Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6. Blenis, J., Spivack, J.G., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  4. Attenuation of ribosomal protein S6 phosphatase activity in chicken embryo fibroblasts transformed by Rous sarcoma virus. Belandia, B., Brautigan, D., Martín-Pérez, J. Mol. Cell. Biol. (1994) [Pubmed]
  5. A chick embryo fibroblast protein kinase recognizing ribosomal protein S6. Activity increase after serum stimulation. Lawen, A., Martini, O.H. FEBS Lett. (1985) [Pubmed]
  6. Use of alternative polyadenylation sites by the chicken S6 ribosomal protein gene. Antione, M., Fried, M. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  7. The histone-like C-terminal extension in ribosomal protein S6 in Aedes and Anopheles mosquitoes is encoded within the distal portion of exon 3. Hernandez, V.P., Higgins, L., Schwientek, M.S., Fallon, A.M. Insect Biochem. Mol. Biol. (2003) [Pubmed]
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