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Gene Review

RpS6  -  Ribosomal protein S6

Drosophila melanogaster

Synonyms: (Rp)S6, 40S ribosomal protein S6, CG10944, DS6, Dmel\CG10944, ...
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Disease relevance of RpS6

  • D.m. L27a is closely related to the mammalian protein that has been found differentially expressed in lung cancer tissues and therefore could be involved in the control of cell proliferation such as the ribosomal protein S6 [1].
  • However, in An. stephensi rpS6 the extension was approximately 70 amino acids longer than that in Ae. albopictus, and at the nucleotide level, it most closely resembled histone H1 proteins from the unicellular eukaryotes Leishmania and Chlamydomonas, and the bacterium Bordetella pertussis [2].

High impact information on RpS6


Biological context of RpS6


Anatomical context of RpS6


Associations of RpS6 with chemical compounds

  • Histone H1-like, lysine-rich low complexity amino acid extensions in mosquito ribosomal proteins RpL23a and RpS6 have evolved independently [13].
  • Finally, phosphopeptide mapping of individual phosphoderivatives, isolated from two-dimensional polyacrylamide gels, indicated that DS6A phosphorylation, in analogy to mammalian S6 phosphorylation, appears to proceed in an ordered fashion [14].

Analytical, diagnostic and therapeutic context of RpS6


  1. Identification of a cDNA clone encoding DIP1-binding protein in Drosophila melanogaster. De Felice, B., Ciarmiello, L.F., Wilson, R.R. Mol. Biol. Rep. (2004) [Pubmed]
  2. The histone-like C-terminal extension in ribosomal protein S6 in Aedes and Anopheles mosquitoes is encoded within the distal portion of exon 3. Hernandez, V.P., Higgins, L., Schwientek, M.S., Fallon, A.M. Insect Biochem. Mol. Biol. (2003) [Pubmed]
  3. Drosophila homolog of the human S6 ribosomal protein is required for tumor suppression in the hematopoietic system. Watson, K.L., Konrad, K.D., Woods, D.F., Bryant, P.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Heat shock induces rapid dephosphorylation of a ribosomal protein in Drosophila. Glover, C.V. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  5. Role of S6 phosphorylation and S6 kinase in cell growth. Volarević, S., Thomas, G. Prog. Nucleic Acid Res. Mol. Biol. (2001) [Pubmed]
  6. Mutations in the Drosophila gene encoding ribosomal protein S6 cause tissue overgrowth. Stewart, M.J., Denell, R. Mol. Cell. Biol. (1993) [Pubmed]
  7. Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Lizcano, J.M., Alrubaie, S., Kieloch, A., Deak, M., Leevers, S.J., Alessi, D.R. Biochem. J. (2003) [Pubmed]
  8. The Drosophila ribosomal protein S6 gene includes a 3' triplication that arose by unequal crossing-over. Stewart, M.J., Denell, R. Mol. Biol. Evol. (1993) [Pubmed]
  9. The nucleotide sequence of a cloned cDNA encoding ribosomal protein S6 from Drosophila melanogaster. Spencer, T.A., Mackie, G.A. Biochim. Biophys. Acta (1993) [Pubmed]
  10. Dephosphorylation of S6 and expression of the heat shock response in Drosophila melanogaster. Olsen, A.S., Triemer, D.F., Sanders, M.M. Mol. Cell. Biol. (1983) [Pubmed]
  11. Drosophila in cancer research: the first fifty tumor suppressor genes. Watson, K.L., Justice, R.W., Bryant, P.J. J. Cell Sci. Suppl. (1994) [Pubmed]
  12. Mitogenesis and protein synthesis: a role for ribosomal protein S6 phosphorylation? Stewart, M.J., Thomas, G. Bioessays (1994) [Pubmed]
  13. Histone H1-like, lysine-rich low complexity amino acid extensions in mosquito ribosomal proteins RpL23a and RpS6 have evolved independently. Hernandez, V.P., Fallon, A.M. Arch. Insect Biochem. Physiol. (2007) [Pubmed]
  14. Identification of insulin-induced sites of ribosomal protein S6 phosphorylation in Drosophila melanogaster. Radimerski, T., Mini, T., Schneider, U., Wettenhall, R.E., Thomas, G., Jenö, P. Biochemistry (2000) [Pubmed]
  15. Characterization of the ribosomal proteins from mosquito (Aedes albopictus) cells. Johnston, A.M., Fallon, A.M. Eur. J. Biochem. (1985) [Pubmed]
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