The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TAL1  -  T-cell acute lymphocytic leukemia 1

Gallus gallus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on TAL1

  • While no hematopoietic cells (HPC) were detected in SCL-null ES cell differentiation cultures, SCL gene reactivation from day 2 to day 4 after initiation of differentiation could rescue both primitive and definitive hematopoiesis [1].
  • We established SCL-null ES cell lines in which SCL expression is rescued by tamoxifen-inducible Cre recombinase-loxP site-mediated recombination [1].
  • Analysis of vertebrate SCL loci identifies conserved enhancers [2].
  • The SCL gene encodes a highly conserved bHLH transcription factor with a pivotal role in hemopoiesis and vasculogenesis [2].
  • JB-transformed bone marrow cells expressed GATA-1, TAL-1, and histone H5, suggesting that they belong to the erythrocytic/thrombocytic lineage [3].
 

Anatomical context of TAL1

  • Stem cell growth becomes predominant while neural plate progenitor pool decreases during spinal cord elongation [4].
 

Analytical, diagnostic and therapeutic context of TAL1

References

  1. SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation. Endoh, M., Ogawa, M., Orkin, S., Nishikawa, S. EMBO J. (2002) [Pubmed]
  2. Analysis of vertebrate SCL loci identifies conserved enhancers. Göttgens, B., Barton, L.M., Gilbert, J.G., Bench, A.J., Sanchez, M.J., Bahn, S., Mistry, S., Grafham, D., McMurray, A., Vaudin, M., Amaya, E., Bentley, D.R., Green, A.R., Sinclair, A.M. Nat. Biotechnol. (2000) [Pubmed]
  3. v-jun cooperates with v-erbB to transform the thrombocytic/megakaryocytic lineage. Garcia, M., Samarut, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Stem cell growth becomes predominant while neural plate progenitor pool decreases during spinal cord elongation. Roszko, I., Faure, P., Mathis, L. Dev. Biol. (2007) [Pubmed]
  5. Molecular cloning of the chicken SCL cDNA. Goodwin, G., MacGregor, A., Zhu, J., Crompton, M.R. Nucleic Acids Res. (1992) [Pubmed]
 
WikiGenes - Universities