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Gene Review

TAL1  -  T-cell acute lymphocytic leukemia 1

Gallus gallus

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High impact information on TAL1

  • While no hematopoietic cells (HPC) were detected in SCL-null ES cell differentiation cultures, SCL gene reactivation from day 2 to day 4 after initiation of differentiation could rescue both primitive and definitive hematopoiesis [1].
  • We established SCL-null ES cell lines in which SCL expression is rescued by tamoxifen-inducible Cre recombinase-loxP site-mediated recombination [1].
  • Analysis of vertebrate SCL loci identifies conserved enhancers [2].
  • The SCL gene encodes a highly conserved bHLH transcription factor with a pivotal role in hemopoiesis and vasculogenesis [2].
  • JB-transformed bone marrow cells expressed GATA-1, TAL-1, and histone H5, suggesting that they belong to the erythrocytic/thrombocytic lineage [3].

Anatomical context of TAL1

  • Stem cell growth becomes predominant while neural plate progenitor pool decreases during spinal cord elongation [4].

Analytical, diagnostic and therapeutic context of TAL1


  1. SCL/tal-1-dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation. Endoh, M., Ogawa, M., Orkin, S., Nishikawa, S. EMBO J. (2002) [Pubmed]
  2. Analysis of vertebrate SCL loci identifies conserved enhancers. Göttgens, B., Barton, L.M., Gilbert, J.G., Bench, A.J., Sanchez, M.J., Bahn, S., Mistry, S., Grafham, D., McMurray, A., Vaudin, M., Amaya, E., Bentley, D.R., Green, A.R., Sinclair, A.M. Nat. Biotechnol. (2000) [Pubmed]
  3. v-jun cooperates with v-erbB to transform the thrombocytic/megakaryocytic lineage. Garcia, M., Samarut, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Stem cell growth becomes predominant while neural plate progenitor pool decreases during spinal cord elongation. Roszko, I., Faure, P., Mathis, L. Dev. Biol. (2007) [Pubmed]
  5. Molecular cloning of the chicken SCL cDNA. Goodwin, G., MacGregor, A., Zhu, J., Crompton, M.R. Nucleic Acids Res. (1992) [Pubmed]
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