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Gene Review

Tal1  -  T cell acute lymphocytic leukemia 1

Mus musculus

Synonyms: Hpt, SCL/tal-1, Scl, Stem cell protein, T-cell acute lymphocytic leukemia protein 1 homolog, ...
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Disease relevance of Tal1


Psychiatry related information on Tal1

  • TAL1 was as effective as Id in both transcriptional suppression and inhibition of differentiation [4].

High impact information on Tal1

  • The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages [5].
  • To define roles in other lineages, we studied the hematopoietic potential of homozygous mutant SCL/tal-1 -/- embryonic stem cells upon in vitro differentiation and in vivo in chimeric mice [5].
  • These findings suggest that SCL/tal-1 functions very early in hematopoietic development, either in specification of ventral mesoderm to a blood cell fate, or in formation or maintenance of immature progenitors [5].
  • The T cell leukemia oncoprotein SCL/tal-1, a basic-helix-loop-helix transcription factor, is required for production of embryonic red blood cells in the mouse yolk sac [5].
  • Here we show that in the absence of SCL/tal-1, hematopoiesis, Including the generation of red cells, myeloid cells, megakaryocytes, mast cells, and both T and B lymphoid cells, is undetectable [5].

Biological context of Tal1


Anatomical context of Tal1


Associations of Tal1 with chemical compounds


Physical interactions of Tal1

  • TAL1 encodes a bHLH protein that exhibits sequence-specific DNA binding activity when it forms dimers with another bHLH protein such as E2A [4].

Regulatory relationships of Tal1

  • Stem cell homing to the injured tissue is regulated through stromal cell derived factor-1 (SDF-1) and its receptor CXCR4 [16].
  • We show that ectopic expression of TAL1 blocks the ability of the bHLH gene myogenin to induce myotube differentiation in C3H10T1/2 cells [4].
  • Here we have shown that TAL1 and the ubiquitously expressed murine bHLH transcription factor ALF1 formed heterodimers that, compared with ALF1 homodimers, had a more restricted E-box specificity and bound preferentially to the glucocorticoid-responsive E-box (Egre) motif (AACAGATGGT) [17].
  • Our studies suggest that hemangioblast specification within Flk-1 expressing mesoderm is regulated by Scl expression [18].
  • Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1 [19].

Other interactions of Tal1


Analytical, diagnostic and therapeutic context of Tal1


  1. Akt phosphorylates Tal1 oncoprotein and inhibits its repressor activity. Palamarchuk, A., Efanov, A., Maximov, V., Aqeilan, R.I., Croce, C.M., Pekarsky, Y. Cancer Res. (2005) [Pubmed]
  2. The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice. O'Neil, J., Billa, M., Oikemus, S., Kelliher, M. Oncogene (2001) [Pubmed]
  3. Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells. Tang, T., Arbiser, J.L., Brandt, S.J. J. Biol. Chem. (2002) [Pubmed]
  4. The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation. Hofmann, T.J., Cole, M.D. Oncogene (1996) [Pubmed]
  5. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Porcher, C., Swat, W., Rockwell, K., Fujiwara, Y., Alt, F.W., Orkin, S.H. Cell (1996) [Pubmed]
  6. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Mikkola, H.K., Fujiwara, Y., Schlaeger, T.M., Traver, D., Orkin, S.H. Blood (2003) [Pubmed]
  7. Tal1 transgenic expression reveals absence of B lymphocytes. Palamarchuk, A., Zanesi, N., Aqeilan, R.I., Efanov, A., Maximov, V., Santanam, U., Hagan, J.P., Croce, C.M., Pekarsky, Y. Cancer Res. (2006) [Pubmed]
  8. SCL assembles a multifactorial complex that determines glycophorin A expression. Lahlil, R., Lécuyer, E., Herblot, S., Hoang, T. Mol. Cell. Biol. (2004) [Pubmed]
  9. Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development in the mouse. Ema, M., Faloon, P., Zhang, W.J., Hirashima, M., Reid, T., Stanford, W.L., Orkin, S., Choi, K., Rossant, J. Genes Dev. (2003) [Pubmed]
  10. Enforced expression of PU.1 rescues osteoclastogenesis from embryonic stem cells lacking Tal-1. Tsuneto, M., Tominaga, A., Yamazaki, H., Yoshino, M., Orkin, S.H., Hayashi, S. Stem Cells (2005) [Pubmed]
  11. Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Muroyama, Y., Fujiwara, Y., Orkin, S.H., Rowitch, D.H. Nature (2005) [Pubmed]
  12. Target-dependent effect of phosphorylation on the DNA binding activity of the TAL1/SCL oncoprotein. Prasad, K.S., Brandt, S.J. J. Biol. Chem. (1997) [Pubmed]
  13. Efficient and repetitive production of hematopoietic and endothelial cells from feeder-free monolayer culture system of primate embryonic stem cells. Zhang, H., Saeki, K., Kimura, A., Saeki, K., Nakahara, M., Doshi, M., Kondo, Y., Nakano, T., Yuo, A. Biol. Reprod. (2006) [Pubmed]
  14. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. Kelliher, M.A., Seldin, D.C., Leder, P. EMBO J. (1996) [Pubmed]
  15. Effects of various treatments of CFU-S seeding efficiency in mice. Dumenil, D., Lauret, E., Frindel, E. Exp. Hematol. (1984) [Pubmed]
  16. Syngenic bone marrow cells restore hepatic function in carbon tetrachloride-induced mouse liver injury. Jung, Y.J., Ryu, K.H., Cho, S.J., Woo, S.Y., Seoh, J.Y., Chun, C.H., Yoo, K., Moon, I.H., Han, H.S. Stem Cells Dev. (2006) [Pubmed]
  17. E-box sequence and context-dependent TAL1/SCL modulation of basic helix-loop-helix protein-mediated transcriptional activation. Nielsen, A.L., Norby, P.L., Pedersen, F.S., Jorgensen, P. J. Biol. Chem. (1996) [Pubmed]
  18. Developmental relationship between hematopoietic and endothelial cells. Lugus, J.J., Park, C., Choi, K. Immunol. Res. (2005) [Pubmed]
  19. Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1. Musarò, A., Giacinti, C., Borsellino, G., Dobrowolny, G., Pelosi, L., Cairns, L., Ottolenghi, S., Cossu, G., Bernardi, G., Battistini, L., Molinaro, M., Rosenthal, N. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  20. Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation. Xu, Z., Huang, S., Chang, L.S., Agulnick, A.D., Brandt, S.J. Mol. Cell. Biol. (2003) [Pubmed]
  21. Helix-loop-helix proteins regulate pre-TCR and TCR signaling through modulation of Rel/NF-kappaB activities. Kim, D., Xu, M., Nie, L., Peng, X.C., Jimi, E., Voll, R.E., Nguyen, T., Ghosh, S., Sun, X.H. Immunity (2002) [Pubmed]
  22. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Yamada, Y., Warren, A.J., Dobson, C., Forster, A., Pannell, R., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  23. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Landry, J.R., Kinston, S., Knezevic, K., de Bruijn, M.F., Wilson, N., Nottingham, W.T., Peitz, M., Edenhofer, F., Pimanda, J.E., Ottersbach, K., Göttgens, B. Blood (2008) [Pubmed]
  24. A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. McCormack, M.P., Hall, M.A., Schoenwaelder, S.M., Zhao, Q., Ellis, S., Prentice, J.A., Clarke, A.J., Slater, N.J., Salmon, J.M., Jackson, S.P., Jane, S.M., Curtis, D.J. Blood (2006) [Pubmed]
  25. Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression of the LIM domain mutants of LMO2. Terano, T., Zhong, Y., Toyokuni, S., Hiai, H., Yamada, Y. Exp. Hematol. (2005) [Pubmed]
  26. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Mikkola, H.K., Klintman, J., Yang, H., Hock, H., Schlaeger, T.M., Fujiwara, Y., Orkin, S.H. Nature (2003) [Pubmed]
  27. Expression of the TAL1/SCL transcription factor in physiological and pathological vascular processes. Tang, T., Shi, Y., Opalenik, S.R., Brantley-Sieders, D.M., Chen, J., Davidson, J.M., Brandt, S.J. J. Pathol. (2006) [Pubmed]
  28. Biomimetic three-dimensional cultures significantly increase hematopoietic differentiation efficacy of embryonic stem cells. Liu, H., Roy, K. Tissue engineering. (2005) [Pubmed]
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