High impact information on MSGN1

• The SCL gene encodes a highly conserved bHLH transcription factor with a pivotal role in hemopoiesis and vasculogenesis [1].
• In addition, Zfp488 can interact and cooperate with the bHLH transcription factor Olig2 to promote precocious and ectopic oligodendrocyte differentiation [2].
• We have found that Scleraxis, a bHLH transcription factor, is a highly specific marker for all the connective tissues that mediate attachment of muscle to bone in chick and mouse, including the limb tendons, and show that early scleraxis expression marks the progenitor cell populations for these tissues [3].
• The bHLH transcription factor cDermo-1 is expressed in developing dermis and is the earliest known marker of prospective feather tracts [4].
• Separable enhancer sequences regulate the expression of the neural bHLH transcription factor neurogenin 1 [5].

Biological context of MSGN1

• eHAND is a bHLH transcription factor with important functions during embryogenesis [6].

Anatomical context of MSGN1

• cMeso-1, a novel bHLH transcription factor, is involved in somite formation in chicken embryos [7].
• We report on novel sites of expression of the bHLH transcription factor NSCL1 in the developing forebrain, hindbrain and spinal cord in chick and mouse [8].
• Visualization of bHLH transcription factor interactions in living mammalian cell nuclei and developing chicken neural tube by FRET [9].
• Expression of a quail bHLH transcription factor is associated with adrenergic development in trunk neural crest cultures [10].
• We isolated chick bHLH transcription factor E12 cDNA and demonstrated its expression in developing neural tube interneurons [11].

Other interactions of MSGN1

• Conversely, overexpression of avian E47, a bHLH transcription factor, leads to a dramatic increase in GC rates independent of IgL or activation-induced cytidine deaminase RNA levels [12].

References