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Gene Review:

C1S - complement component 1, s subcomponent

Sus scrofa

Klima, U. et al., Horstick, G. et al., Heikkinen, J. et al., Horstick, G. et al., Khorram-Sefat, R. et al., et al.

Klima, Kutschka, Warnecke, Kim, Strüber, Kirschfink, Haverich,

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Disease relevance of C1S

Intracoronary application of C1 esterase inhibitor improves cardiac function and reduces myocardial necrosis in an experimental model of ischemia and reperfusion [1].
Apotransferrin (Apo-Tf), alpha 1-acid glycoprotein (AGP), and C1-esterase inhibitor (C1-INH) have been herein evaluated as potential beneficial agents in reducing the ischemia-reperfusion injury in a surviving model of HCA [2].
Observations on the ultrastructure of lesions induced in human and guinea pig skin by C 1 esterase and polypeptide from hereditary angioneurotic edema (HANE) plasma [3].

High impact information on C1S

C1-esterase inactivator from cancer cells is C-reactive protein [4].
Genes induced by IFNs (GBP1, GBP2, C1S, C1R, MHC2TA, PSMB8, TAP1, TAP2) showed increased expression during porcine lung infection [5].
To test the effects of C1-esterase inhibitor in scald burns on bacterial translocation and intestinal damage, standardized deep partial-thickness burns were inflicted on domestic pigs, scalding 30% of the skin surface for 25 s with 75 degrees C hot water [6].
Improved right ventricular function after intracoronary administration of a C1 esterase inhibitor in a right heart transplantation model [7].
Our study addresses the question whether the most susceptible region of the heart for ischemic injury, the right ventricle (RV), can benefit from the protective effects of C1 esterase inhibition after transplantation [7].

Chemical compound and disease context of C1S

It has been shown that intracoronary administration of a C1 esterase inhibitor (C1 INH) significantly reduces myocardial necrosis in an experimental model of ischemia [7].

Biological context of C1S

BACKGROUND: Complement activation during reperfusion of ischemic myocardium augments myocardial injury, and complement inhibition with C1-esterase inhibitor (C1-INH) at the time of reperfusion exerts marked cardioprotective effects in experimental studies [8].

Anatomical context of C1S

Application of C1-esterase inhibitor during reperfusion of ischemic myocardium: dose-related beneficial versus detrimental effects [8].

Associations of C1S with chemical compounds

Apotransferrin, C1-esterase inhibitor, and alpha 1-acid glycoprotein for cerebral protection during experimental hypothermic circulatory arrest [2].
10 received no treatment, and 5 were given a combination of methylprednisolone, naloxone, ketanserin, promethazine, C1 esterase inhibitor, antithrombin III and aprotinin [9].

Analytical, diagnostic and therapeutic context of C1S

The present study addresses the possibility of reducing reperfusion damage by the application of C1 esterase inhibitor (C1-INH) [1].
Pretreatment with C1-esterase inhibitor improves cardiovascular stability in small primates undergoing porcine kidney xenotransplantation [10].

References

Intracoronary application of C1 esterase inhibitor improves cardiac function and reduces myocardial necrosis in an experimental model of ischemia and reperfusion. Horstick, G., Heimann, A., Götze, O., Hafner, G., Berg, O., Böehmer, P., Becker, P., Darius, H., Rupprecht, H.J., Loos, M., Bhakdi, S., Meyer, J., Kempski, O. Circulation (1997) [Pubmed]
Apotransferrin, C1-esterase inhibitor, and alpha 1-acid glycoprotein for cerebral protection during experimental hypothermic circulatory arrest. Heikkinen, J., Koskenkari, J., Kaakinen, T., Dahlbacka, S., Kiviluoma, K., Salomäki, T., Laurila, P., Hirvonen, J., Biancari, F., Parkkinen, J., Juvonen, T. Scand. Cardiovasc. J. (2004) [Pubmed]
Observations on the ultrastructure of lesions induced in human and guinea pig skin by C 1 esterase and polypeptide from hereditary angioneurotic edema (HANE) plasma. Willms, K., Rosen, F.S., Donaldson, V.H. Clin. Immunol. Immunopathol. (1975) [Pubmed]
C1-esterase inactivator from cancer cells is C-reactive protein. Darhovsky, D., Ziegenhagen, G., Duchmann, H. Lancet (1980) [Pubmed]
Gene expression profiling in Salmonella Choleraesuis-infected porcine lung using a long oligonucleotide microarray. Zhao, S.H., Kuhar, D., Lunney, J.K., Dawson, H., Guidry, C., Uthe, J.J., Bearson, S.M., Recknor, J., Nettleton, D., Tuggle, C.K. Mamm. Genome (2006) [Pubmed]
The therapeutic effect of C1-inhibitor on gut-derived bacterial translocation after thermal injury. Khorram-Sefat, R., Goldmann, C., Radke, A., Lennartz, A., Mottaghy, K., Afify, M., Küpper, W., Klosterhalfen, B. Shock (1998) [Pubmed]
Improved right ventricular function after intracoronary administration of a C1 esterase inhibitor in a right heart transplantation model. Klima, U., Kutschka, I., Warnecke, G., Kim, P., Strüber, M., Kirschfink, M., Haverich, A. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2000) [Pubmed]
Application of C1-esterase inhibitor during reperfusion of ischemic myocardium: dose-related beneficial versus detrimental effects. Horstick, G., Berg, O., Heimann, A., Götze, O., Loos, M., Hafner, G., Bierbach, B., Petersen, S., Bhakdi, S., Darius, H., Horstick, M., Meyer, J., Kempski, O. Circulation (2001) [Pubmed]
Effects of a combined drug regimen on tumour necrosis factor and plasma kallikrein activity in experimental endotoxaemia. Naess, F., Waage, A., Roeise, O., Stadaas, J.O., Aasen, A.O. The European journal of surgery = Acta chirurgica. (1994) [Pubmed]
Pretreatment with C1-esterase inhibitor improves cardiovascular stability in small primates undergoing porcine kidney xenotransplantation. Przemeck, M., Lorenz, R., Vangerow, B., Klempnauer, J., Winkler, M., Piepenbrock, S. Transplant. Proc. (2002) [Pubmed]

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