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Gene Review

MC4R  -  melanocortin 4 receptor

Sus scrofa

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Disease relevance of MC4R


High impact information on MC4R


Biological context of MC4R


Associations of MC4R with chemical compounds


Other interactions of MC4R

  • The mutant Asn298 allele of the MC4R gene was significantly associated with increased test daily gain, higher lean meat percentage and lower backfat thickness [9].


  1. Association of the melanocortin 4 receptor with feed intake and daily gain in F2 Mangalitsa x Piétrain pigs. Meidtner, K., Wermter, A.K., Hinney, A., Remschmidt, H., Hebebrand, J., Fries, R. Anim. Genet. (2006) [Pubmed]
  2. A melanocortin-4 receptor (MC4R) polymorphism is associated with performance traits in divergently selected Large White pig populations. Houston, R.D., Cameron, N.D., Rance, K.A. Anim. Genet. (2004) [Pubmed]
  3. Candidate gene analysis for quantitative traits using the transmission disequilibrium test: the example of the melanocortin 4-receptor in pigs. Hernández-Sánchez, J., Visscher, P., Plastow, G., Haley, C. Genetics (2003) [Pubmed]
  4. An effect of a missense mutation in the porcine melanocortin-4 receptor (MC4R) gene on production traits in Polish pig breeds is doubtful. Stachowiak, M., Szydlowski, M., Obarzanek-Fojt, M., Switonski, M. Anim. Genet. (2006) [Pubmed]
  5. Evaluation of the porcine melanocortin 4 receptor (MC4R) gene as a positional candidate for a fatness QTL in a cross between Landrace and Hampshire. Bruun, C.S., Jørgensen, C.B., Nielsen, V.H., Andersson, L., Fredholm, M. Anim. Genet. (2006) [Pubmed]
  6. Association of melanocortin 4 receptor (MC4R) and high mobility group AT-hook 1 (HMGA1) polymorphisms with pig growth and fat deposition traits. Kim, K.S., Lee, J.J., Shin, H.Y., Choi, B.H., Lee, C.K., Kim, J.J., Cho, B.W., Kim, T.H. Anim. Genet. (2006) [Pubmed]
  7. Melanocortin-4 receptor (MC4R) genotypes have no major effect on fatness in a Large White x Wild Boar intercross. Park, H.B., Carlborg, O., Marklund, S., Andersson, L. Anim. Genet. (2002) [Pubmed]
  8. Functional and phylogenetic analyses of a melanocortin-4 receptor mutation in domestic pigs. Kim, K.S., Reecy, J.M., Hsu, W.H., Anderson, L.L., Rothschild, M.F. Domest. Anim. Endocrinol. (2004) [Pubmed]
  9. Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs. Jokubka, R., Maak, S., Kerziene, S., Swalve, H.H. J. Anim. Breed. Genet. (2006) [Pubmed]
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