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Gene Review

eomes  -  eomesodermin

Xenopus laevis

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High impact information on LOC398065


Anatomical context of LOC398065

  • A recent study has shown that the T-box gene eomesodermin, which was first identified in Xenopus, not only plays a conserved role in vertebrates directing gastrulation, but interestingly in mammals has acquired a new function in the development of the trophoblast [4].
  • At gastrulation, eomesodermin is expressed in the primitive streak and embryonic mesoderm as well, but this expression disappears prior to the end of gastrulation [5].
  • However, during tail-bud stages, Eomes expression is re-born in the most anterior part of the brain, becoming strongly transcribed in the olfactory region of the telencephalon [6].
  • We report the expression pattern of a murine homolog of the Xenopus laevis T-box gene Eomesodermin. mEomes expression is first detected in the extra-embryonic ectoderm prior to gastrulation, and persists there until head-fold stages [7].
  • This later Eomes expression marks a very localized region of the forebrain distinct from that of Otx-2, anterior to that of En-1 and overlapping that of Sox-3 [6].

Other interactions of LOC398065

  • We have used differential display to identify genes inducible by activin and isolated a novel member of the T-box gene family that includes the Xenopus genes Xbrachyury and Eomesodermin [8].

Analytical, diagnostic and therapeutic context of LOC398065

  • Modulation of eomes activity alters the size of the developing heart: implications for in utero cardiac gene therapy [9].


  1. Eomesodermin, a key early gene in Xenopus mesoderm differentiation. Ryan, K., Garrett, N., Mitchell, A., Gurdon, J.B. Cell (1996) [Pubmed]
  2. The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation. Bruce, A.E., Howley, C., Zhou, Y., Vickers, S.L., Silver, L.M., King, M.L., Ho, R.K. Development (2003) [Pubmed]
  3. The Xenopus eomesodermin promoter and its concentration-dependent response to activin. Ryan, K., Garrett, N., Bourillot, P., Stennard, F., Gurdon, J.B. Mech. Dev. (2000) [Pubmed]
  4. Mammalian development: new trick for an old dog. Graham, A. Curr. Biol. (2000) [Pubmed]
  5. Mapping and expression analysis of the mouse ortholog of Xenopus Eomesodermin. Hancock, S.N., Agulnik, S.I., Silver, L.M., Papaioannou, V.E. Mech. Dev. (1999) [Pubmed]
  6. Xenopus eomesodermin is expressed in neural differentiation. Ryan, K., Butler, K., Bellefroid, E., Gurdon, J.B. Mech. Dev. (1998) [Pubmed]
  7. Expression of the T-box gene Eomesodermin during early mouse development. Ciruna, B.G., Rossant, J. Mech. Dev. (1999) [Pubmed]
  8. The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation. Stennard, F., Carnac, G., Gurdon, J.B. Development (1996) [Pubmed]
  9. Modulation of eomes activity alters the size of the developing heart: implications for in utero cardiac gene therapy. Ryan, K., Russ, A.P., Levy, R.J., Wehr, D.J., You, J., Easterday, M.C. Hum. Gene Ther. (2004) [Pubmed]
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