Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

eomes - eomesodermin

Xenopus laevis

Ryan, K. et al., Bruce, A.E. et al., Graham, A., Ryan, K. et al., Ciruna, B.G. et al., et al.

Ryan, Russ, Levy, Wehr, You, Easterday, Bruce, Howley, Zhou, Vickers, Silver, King, Ho, Graham, Ryan, Garrett, Bourillot, Stennard, Gurdon,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on LOC398065

We propose that Eomes fulfills an essential function in initiating mesoderm differentiation and in determining mesodermal cell fate [1].
Blocking the function of Eomes causes gastrulation arrest and defective mesoderm-dependent gene activation [1].
We have cloned and characterized a maternal T-box gene in the zebrafish, eomesodermin (eomes) [2].
After fertilization during early cleavage stages, eomes is expressed in a vegetal to animal gradient in the embryo, whereas Eomesodermin protein (Eom) is distributed cytoplasmically throughout the blastoderm [2].
Eomesodermin is an essential early gene in Xenopus mesoderm formation and shows a morphogen-like response to activin [3].

Anatomical context of LOC398065

A recent study has shown that the T-box gene eomesodermin, which was first identified in Xenopus, not only plays a conserved role in vertebrates directing gastrulation, but interestingly in mammals has acquired a new function in the development of the trophoblast [4].
At gastrulation, eomesodermin is expressed in the primitive streak and embryonic mesoderm as well, but this expression disappears prior to the end of gastrulation [5].
However, during tail-bud stages, Eomes expression is re-born in the most anterior part of the brain, becoming strongly transcribed in the olfactory region of the telencephalon [6].
We report the expression pattern of a murine homolog of the Xenopus laevis T-box gene Eomesodermin. mEomes expression is first detected in the extra-embryonic ectoderm prior to gastrulation, and persists there until head-fold stages [7].
This later Eomes expression marks a very localized region of the forebrain distinct from that of Otx-2, anterior to that of En-1 and overlapping that of Sox-3 [6].

Other interactions of LOC398065

We have used differential display to identify genes inducible by activin and isolated a novel member of the T-box gene family that includes the Xenopus genes Xbrachyury and Eomesodermin [8].

Analytical, diagnostic and therapeutic context of LOC398065

Modulation of eomes activity alters the size of the developing heart: implications for in utero cardiac gene therapy [9].

References

Eomesodermin, a key early gene in Xenopus mesoderm differentiation. Ryan, K., Garrett, N., Mitchell, A., Gurdon, J.B. Cell (1996) [Pubmed]
The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation. Bruce, A.E., Howley, C., Zhou, Y., Vickers, S.L., Silver, L.M., King, M.L., Ho, R.K. Development (2003) [Pubmed]
The Xenopus eomesodermin promoter and its concentration-dependent response to activin. Ryan, K., Garrett, N., Bourillot, P., Stennard, F., Gurdon, J.B. Mech. Dev. (2000) [Pubmed]
Mammalian development: new trick for an old dog. Graham, A. Curr. Biol. (2000) [Pubmed]
Mapping and expression analysis of the mouse ortholog of Xenopus Eomesodermin. Hancock, S.N., Agulnik, S.I., Silver, L.M., Papaioannou, V.E. Mech. Dev. (1999) [Pubmed]
Xenopus eomesodermin is expressed in neural differentiation. Ryan, K., Butler, K., Bellefroid, E., Gurdon, J.B. Mech. Dev. (1998) [Pubmed]
Expression of the T-box gene Eomesodermin during early mouse development. Ciruna, B.G., Rossant, J. Mech. Dev. (1999) [Pubmed]
The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation. Stennard, F., Carnac, G., Gurdon, J.B. Development (1996) [Pubmed]
Modulation of eomes activity alters the size of the developing heart: implications for in utero cardiac gene therapy. Ryan, K., Russ, A.P., Levy, R.J., Wehr, D.J., You, J., Easterday, M.C. Hum. Gene Ther. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.