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Gene Review

arcA  -  two-component response regulator

Escherichia coli UTI89

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Disease relevance of arcA

  • The AD gene, designated arcA, was expressed from recombinant bacteriophage or in cells harboring plasmid subclones from this phage at a level up to 1,000-fold lower than the level in fully derepressed S. sanguis but apparently under the control of its own promoter [1].
  • In this study, we examined the overproduction of a model recombinant protein in strains of E. coli expressing NOX with or without an arcA mutation [2].

High impact information on arcA

  • For one of these genes, arcA, an insertion mutant was generated and its biofilm-related phenotype was examined [3].
  • Results from both the transposon array and insertion mutagenesis indicated that arcA, which is known to be a negative response regulator of genes in aerobic pathways, was important for competitiveness in E. coli PHL628 biofilms [3].
  • Functional citric acid cycle in an arcA mutant of Escherichia coli during growth with nitrate under anoxic conditions [4].
  • Glucose, on the other hand, was excreted mostly as acetate by the wild-type and by the arcA mutant [4].
  • In an arcA mutant devoid of the transcriptional regulator ArcA, glycerol was completely oxidized with nitrate as an electron acceptor, demonstrating derepression and function of the complete pathway [4].

Chemical compound and disease context of arcA

  • To systematically investigate the contribution of Arc- and Fnr-dependent regulation in catabolism, glucose-limited chemostat cultures were conducted on wild-type E. coli, an arcA mutant, an fnr mutant, and an arcAfnr double mutant strains under a well-defined semi-aerobic condition [5].

Biological context of arcA


Anatomical context of arcA


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