Disease relevance of arcA

• The AD gene, designated arcA, was expressed from recombinant bacteriophage or in cells harboring plasmid subclones from this phage at a level up to 1,000-fold lower than the level in fully derepressed S. sanguis but apparently under the control of its own promoter [1].
• In this study, we examined the overproduction of a model recombinant protein in strains of E. coli expressing NOX with or without an arcA mutation [2].

High impact information on arcA

• For one of these genes, arcA, an insertion mutant was generated and its biofilm-related phenotype was examined [3].
• Results from both the transposon array and insertion mutagenesis indicated that arcA, which is known to be a negative response regulator of genes in aerobic pathways, was important for competitiveness in E. coli PHL628 biofilms [3].
• Functional citric acid cycle in an arcA mutant of Escherichia coli during growth with nitrate under anoxic conditions [4].
• Glucose, on the other hand, was excreted mostly as acetate by the wild-type and by the arcA mutant [4].
• In an arcA mutant devoid of the transcriptional regulator ArcA, glycerol was completely oxidized with nitrate as an electron acceptor, demonstrating derepression and function of the complete pathway [4].

Chemical compound and disease context of arcA

• To systematically investigate the contribution of Arc- and Fnr-dependent regulation in catabolism, glucose-limited chemostat cultures were conducted on wild-type E. coli, an arcA mutant, an fnr mutant, and an arcAfnr double mutant strains under a well-defined semi-aerobic condition [5].

Biological context of arcA

• The arcA open reading frame specifies a polypeptide of 46.3 kDa [6].
• We have determined the nucleotide sequences of the arcA and arcC genes [6].

Anatomical context of arcA

• Effect of the arcA Mutation on the Expression of Flagella Genes in Escherichia coli [7].

References