The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

CycT  -  Cyclin T

Drosophila melanogaster

Synonyms: CG6292, Cyclin-T, Dmcyclin T, Dmel\CG6292, ORE-14, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CycT

  • Cdk9 has also been described as the kinase of the TAK complex, which is homologous to the P-TEFb complex and involved in HIV replication [1].

High impact information on CycT

  • P-TEFb, a heterodimer of the kinase Cdk9 and cyclin T, was isolated as a factor that stimulates formation of productive transcription elongation complexes in vitro [2].
  • Here, we show that P-TEFb is located at >200 distinct sites on Drosophila polytene chromosomes [2].
  • Cyclin T2 has two forms (T2a and T2b) because of alternative splicing [3].
  • Kc cell nuclear extract depleted of P-TEFb failed to generate long DRB-sensitive transcripts, but this activity was restored upon addition of either native or recombinant P-TEFb [4].
  • We now name the large subunit cyclin T and the previously cloned small subunit (Zhu, Y. R., Peery, T., Peng, J. M., Ramanathan, Y., Marshall, N., Marshall, T., Amendt, B., Mathews, M. B., and Price, D. H. (1997) Genes Dev. 11, 2622-2632) cyclin-dependent kinase 9 (CDK9) [4].

Biological context of CycT


  1. CDK9: from basal transcription to cancer and AIDS. De Falco, G., Giordano, A. Cancer Biol. Ther. (2002) [Pubmed]
  2. P-TEFb kinase recruitment and function at heat shock loci. Lis, J.T., Mason, P., Peng, J., Price, D.H., Werner, J. Genes Dev. (2000) [Pubmed]
  3. Identification of multiple cyclin subunits of human P-TEFb. Peng, J., Zhu, Y., Milton, J.T., Price, D.H. Genes Dev. (1998) [Pubmed]
  4. Identification of a cyclin subunit required for the function of Drosophila P-TEFb. Peng, J., Marshall, N.F., Price, D.H. J. Biol. Chem. (1998) [Pubmed]
  5. Control of RNA polymerase II elongation potential by a novel carboxyl-terminal domain kinase. Marshall, N.F., Peng, J., Xie, Z., Price, D.H. J. Biol. Chem. (1996) [Pubmed]
  6. Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression. Romano, G., Kasten, M., De Falco, G., Micheli, P., Khalili, K., Giordano, A. J. Cell. Biochem. (1999) [Pubmed]
  7. Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Eissenberg, J.C., Shilatifard, A., Dorokhov, N., Michener, D.E. Mol. Genet. Genomics (2007) [Pubmed]
WikiGenes - Universities