Disease relevance of TGM1

• Evidence of anti-gliadin and transglutaminase antibodies in sera of dogs affected by lymphoplasmacytic enteritis [1].

High impact information on TGM1

• Enhanced transglutaminase activity associated with macrophage activation. Possible role in Fc-mediated phagocytosis [2].
• Many of these primary amines are not only lysosomotropic agents but also potent inhibitors of transglutaminase activity when assayed in MDCK cell extracts, at concentrations correlating with those effective in stimulation of dome formation [3].
• Lysosomotropic agents and inhibitors of cellular transglutaminase stimulate dome formation, a differentiated characteristic of MDCK kidney epithelial cell cultures [3].
• Other lysosomotropic agents such as chloroquine and secondary and tertiary amines stimulated dome formation yet did not inhibit transglutaminase [3].
• Dirofilaria immitis: further characterization of the transglutaminase enzyme and its role in larval molting [4].

Biological context of TGM1

• DNA sequence and physical mapping of the canine transglutaminase 1 gene [5].

References