Disease relevance of DCN

• Expression of biglycan, decorin and fibromodulin in the hypertrophic phase of experimental osteoarthritis [1].

High impact information on DCN

• There were no changes in the relative proportions of aggrecan and decorin/biglycan extracted from and synthesized by control and experimental OA cartilage over the 3 days in culture [2].
• Increase of decorin content in articular cartilage following running [3].
• The first comprised a narrow glycocalyx, 1-3 microns in width, which consolidated over time and was rich in collagen types II, VI, IX and XI, fibronectin, decorin and the aggrecan epitopes, 5D4 and HABR [4].

Anatomical context of DCN

• Decorin and biglycan staining was faint within the extracellular matrix of the regenerating defect, although both proteoglycans exhibited intense intracellular localization within some of the cells inhabiting the defect [5].

Analytical, diagnostic and therapeutic context of DCN

• The relative levels of mRNA for biglycan, decorin and fibromodulin were assessed by northern blot analyses [1].

References