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Gene Review

DCN  -  decorin

Canis lupus familiaris

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Disease relevance of DCN


High impact information on DCN

  • There were no changes in the relative proportions of aggrecan and decorin/biglycan extracted from and synthesized by control and experimental OA cartilage over the 3 days in culture [2].
  • Increase of decorin content in articular cartilage following running [3].
  • The first comprised a narrow glycocalyx, 1-3 microns in width, which consolidated over time and was rich in collagen types II, VI, IX and XI, fibronectin, decorin and the aggrecan epitopes, 5D4 and HABR [4].

Anatomical context of DCN

  • Decorin and biglycan staining was faint within the extracellular matrix of the regenerating defect, although both proteoglycans exhibited intense intracellular localization within some of the cells inhabiting the defect [5].

Analytical, diagnostic and therapeutic context of DCN


  1. Expression of biglycan, decorin and fibromodulin in the hypertrophic phase of experimental osteoarthritis. Dourado, G.S., Adams, M.E., Matyas, J.R., Huang, D. Osteoarthr. Cartil. (1996) [Pubmed]
  2. Increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype. Venn, G., Billingham, M.E., Hardingham, T.E. Arthritis Rheum. (1995) [Pubmed]
  3. Increase of decorin content in articular cartilage following running. Visser, N.A., de Koning, M.H., Lammi, M.J., Häkkinen, T., Tammi, M., van Kampen, G.P. Connect. Tissue Res. (1998) [Pubmed]
  4. Confocal analysis of the molecular heterogeneity in the pericellular microenvironment produced by adult canine chondrocytes cultured in agarose gel. Chang, J., Poole, C.A. Histochem. J. (1997) [Pubmed]
  5. An immunohistochemical study of matrix molecules associated with barrier membrane-mediated periodontal wound healing. Ivanovski, S., Li, H., Daley, T., Bartold, P.M. J. Periodont. Res. (2000) [Pubmed]
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