The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DCN  -  decorin

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of DCN


High impact information on DCN


Chemical compound and disease context of DCN

  • In the current study, chicken myogenic satellite cells isolated from the pectoralis major muscle from the chicken genetic muscle weakness, low score normal (LSN), and normal pectoralis major muscle were used to investigate TGF-beta expression as it relates to decorin and beta1 integrin mRNA expression [6].

Biological context of DCN


Anatomical context of DCN

  • The effects of beta-D-xyloside on the synthesis of proteoglycans by skeletal muscle: lack of effect on decorin and differential polymerization of core protein-bound and xyloside-linked chondroitin sulfate [11].
  • Decorin is highly expressed in sclera and sternum, whereas lumican is expressed in these tissues, as well as in liver, at very low levels [7].
  • Exercise led to an increase in the size of the tendons, the content of hyaluronic acid, and the level of decorin [12].
  • Immunolocalization of these proteoglycans shows that versican is initially present in pericellular locations around developing myotubes, whereas decorin is observed in the epimysium early in development, and then its distribution gradually spreads to also include the perimysium and endomysium [13].
  • Based on the reported functions of decorin as a regulator of cell proliferation and collagen fibril organization, it is possible that the late embryonic increase in decorin may be influencing the alterations in LSN sarcomere and collagen organization [14].

Associations of DCN with chemical compounds

  • cDNA clone to chick corneal chondroitin/dermatan sulfate proteoglycan reveals identity to decorin [15].
  • Chick decorin contains three variations of this sequence that are tandemly linked to form a unit and three units tandemly linked to form the leucine-rich region [15].
  • Similarly, EDTA selectively removed decorin compared with HCl, formic, acetic, or citric acids [16].
  • The addition of exogenous TGF-beta decreased decorin expression during differentiation and reduced beta1 integrin expression at 24 and 48 h of differentiation [6].
  • Monoclonal antibodies 6D6, CS-56 and AH12 specific to dermatan sulphate proteoglycan (decorin), chondroitin sulphate and keratan sulphate, respectively, were used [17].

Other interactions of DCN

  • A 19-amino-acid match with sequence from the N-terminus of core protein from the corneal chondroitin/dermatan sulfate proteoglycan confirmed the clone as a corneal proteoglycan and the homology with human and bovine decorin confirmed its identity as decorin [15].
  • SDS-PAGE indicated that decorin was present in all regions and fibromodulin was mainly observed in the tensile region [18].
  • The LSN condition has elevated expression of TGF-beta2 and TGF-beta4 with increased expression of decorin and decreased beta1 integrin during myogenic satellite cell proliferation and differentiation [6].
  • Compared to normal skeletal muscle, LSN muscle has normal myosin isoform switching and cell-cell recognition, elevated glycosaminoglycan and decorin levels at embryonic Day 20, and a large increase in collagen crosslinking at 6 wk posthatch [10].

Analytical, diagnostic and therapeutic context of DCN


  1. The avian low score normal muscle weakness alters decorin expression and collagen crosslinking. Velleman, S.G., Yeager, J.D., Krider, H., Carrino, D.A., Zimmerman, S.D., McCormick, R.J. Connect. Tissue Res. (1996) [Pubmed]
  2. Low score normal muscle weakness alters cardiac decorin expression: implication for cardiac collagen fibril organization. Velleman, S.G., Ely, D. Poult. Sci. (2001) [Pubmed]
  3. Loss of decorin from the surface zone of articular cartilage in a chick model of osteoarthritis. Massé, P.G., Carrino, D.A., Morris, N., Wenger, L., Mahuren, J.D., Howell, D.S. Acta Histochem. (1997) [Pubmed]
  4. Distinct isoforms of chicken decorin contain either one or two dermatan sulfate chains. Blaschke, U.K., Hedbom, E., Bruckner, P. J. Biol. Chem. (1996) [Pubmed]
  5. Isolation and partial characterization of lumican and decorin from adult chicken corneas. A keratan sulfate-containing isoform of decorin is developmentally regulated. Blochberger, T.C., Cornuet, P.K., Hassell, J.R. J. Biol. Chem. (1992) [Pubmed]
  6. Effect of transforming growth factor-beta on decorin and beta1 integrin expression during muscle development in chickens. Li, X., McFarland, D.C., Velleman, S.G. Poult. Sci. (2006) [Pubmed]
  7. Molecular cloning and relative tissue expression of decorin and lumican in embryonic quail cornea. Corpuz, L.M., Dunlevy, J.R., Hassell, J.R., Conrad, A.H., Conrad, G.W. Matrix Biol. (2000) [Pubmed]
  8. Transforming growth factor-beta gene expression in avian Low Score Normal pectoral muscle. Velleman, S.G., Coy, C.S. Poult. Sci. (1998) [Pubmed]
  9. Myotube morphology, and expression and distribution of collagen type I during normal and low score normal avian satellite cell myogenesis. Velleman, S.G., McFarland, D.C. Dev. Growth Differ. (1999) [Pubmed]
  10. Decorin and collagen type I gene expression in avian low score normal pectoral muscle. Velleman, S.G., Coy, C.S. Poult. Sci. (1997) [Pubmed]
  11. The effects of beta-D-xyloside on the synthesis of proteoglycans by skeletal muscle: lack of effect on decorin and differential polymerization of core protein-bound and xyloside-linked chondroitin sulfate. Carrino, D.A., Caplan, A.I. Matrix Biol. (1994) [Pubmed]
  12. Proteoglycans in chicken gastrocnemius tendons change with exercise. Hae Yoon, J., Brooks, R., Hwan Kim, Y., Terada, M., Halper, J. Arch. Biochem. Biophys. (2003) [Pubmed]
  13. Dynamic expression of proteoglycans during chicken skeletal muscle development and maturation. Carrino, D.A., Sorrell, J.M., Caplan, A.I. Poult. Sci. (1999) [Pubmed]
  14. Alterations in sarcomere structure, collagen organization, mitochondrial activity, and protein metabolism in the avian low score normal muscle weakness. Velleman, S.G., McFarland, D.C., Li, Z., Ferrin, N.H., Whitmoyer, R., Dennis, J.E. Dev. Growth Differ. (1997) [Pubmed]
  15. cDNA clone to chick corneal chondroitin/dermatan sulfate proteoglycan reveals identity to decorin. Li, W., Vergnes, J.P., Cornuet, P.K., Hassell, J.R. Arch. Biochem. Biophys. (1992) [Pubmed]
  16. Selective extractability of noncollagenous proteins from chicken bone. Gerstenfeld, L.C., Feng, M., Gotoh, Y., Glimcher, M.J. Calcif. Tissue Int. (1994) [Pubmed]
  17. Light microscopic histochemical and immunohistochemical localisation of sulphated glycosaminoglycans in the rooster comb and wattle tissues. Nakano, T., Imai, S., Koga, T., Sim, J.S. J. Anat. (1996) [Pubmed]
  18. Biochemical and biomechanical analysis of tendons of caged and penned chickens. Benevides, G., Pimentel, E., Toyama, M., Novello, J.C., Marangoni, S., Gomes, L. Connect. Tissue Res. (2004) [Pubmed]
  19. Increased aggrecan (cartilage proteoglycan) production in the sclera of myopic chicks. Rada, J.A., Thoft, R.A., Hassell, J.R. Dev. Biol. (1991) [Pubmed]
  20. Distribution of small proteoglycans and glycosaminoglycans in humerus-related articular cartilage of chickens. Rodrigues, E.D., Pimentel, E.R., Mourão, P.A., Gomes, L. Braz. J. Med. Biol. Res. (2005) [Pubmed]
WikiGenes - Universities