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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Glycocalyx


High impact information on Glycocalyx


Chemical compound and disease context of Glycocalyx


Biological context of Glycocalyx


Anatomical context of Glycocalyx


Associations of Glycocalyx with chemical compounds

  • The glycocalyx was absent on organisms fixed without osmium and was partially lost when parasites aggregated in their own secretions before fixation [25].
  • Thus it has become feasible to visualize habitats of two surface enzymes, angiotensin-converting enzyme and carboxypeptidase N. Efforts to visualize surface enzymes required development of means of replicating cell surfaces, a methodology that in turn provided the first en face view of the glycocalyx [26].
  • These results, coupled with those of previous studies of permeability changes induced by sialic acid removal, indicate that control of cellular Ca permeability resides in at least two separate sites at the cellular surface: (1) the glycocalyx and (2) the lipid bilayer [27].
  • Glycocalicin, a major glycoprotein of the platelet glycocalyx, is obtained in soluble forms following platelet homogenization and has been purified to homogeneity [28].
  • Since sialic acids are located terminally on the bronchoalveolar lining cells' glycocalyx and play crucial roles, we focused mainly on the existing lung histochemical and biochemical data of these sugar residues, as well as their evolution throughout lung development [29].

Gene context of Glycocalyx

  • These results suggest (1) that the intact distal tubular epithelium of the human kidney does not bind crystals, and (2) that crystal retention in the human kidney may depend on the expression of CD44-, OPN-, and-HA rich cell coats by damaged distal tubular epithelium [30].
  • Cytofluorimetry of disaggregated cervical squames confirmed membranous expression and immunogold labelling of ultrathin cryostat sections localized CEA to the glycocalyx and to within cytoplasmic membrane-bound vesicles of mature squames [31].
  • Mucin glycoproteins are major constituents of the glycocalyx that covers mucosal epithelium [32].
  • As it approaches the maternal surface, the attaching embryo encounters the epithelial glycocalyx, which contains the mucin, MUC1 [33].
  • In the cell coat of the cardiomyocytes of the bare heart tube the fibronectin and laminin are concentrated in patches [34].

Analytical, diagnostic and therapeutic context of Glycocalyx


  1. Gene therapy with extracellular superoxide dismutase attenuates myocardial stunning in conscious rabbits. Li, Q., Bolli, R., Qiu, Y., Tang, X.L., Murphree, S.S., French, B.A. Circulation (1998) [Pubmed]
  2. Carcinoembryonic antigen in human ovarian neoplasms. Marchand, A., Fenoglio, C.M., Pascal, R., Richart, R.M., Bennett, S. Cancer Res. (1975) [Pubmed]
  3. Ca depletion of the sarcolemma--ultrastructural changes. Frank, J.S. Eur. Heart J. (1983) [Pubmed]
  4. Taurine depresses INa and depolarises the membrane but does not affect membrane surface charges in perfused rabbit hearts. Dumaine, R., Schanne, O.F., Ruiz-Petrich, E. Cardiovasc. Res. (1990) [Pubmed]
  5. The role of glycocalyx in surface phagocytosis of Bacteroides spp., in the presence and absence of clindamycin. Veringa, E.M., Ferguson, D.A., Lambe, D.W., Verhoef, J. J. Antimicrob. Chemother. (1989) [Pubmed]
  6. Antigenicity of the infected-erythrocyte and merozoite surfaces in Falciparum malaria. Langreth, S.G., Reese, R.T. J. Exp. Med. (1979) [Pubmed]
  7. Identification of a major sialoprotein in the glycocalyx of human visceral glomerular epithelial cells. Kerjaschki, D., Poczewski, H., Dekan, G., Horvat, R., Balzar, E., Kraft, N., Atkins, R.C. J. Clin. Invest. (1986) [Pubmed]
  8. Ruthenium red-staining coat of paired neoplastic and nonneoplastic mouse cell lines in cluture. Sanford, K.K., Hall, W.T., Hobbs, B.A., Hursey, M.L. J. Natl. Cancer Inst. (1976) [Pubmed]
  9. Regulation of extracellular matrix assembly: in vitro reconstitution of a partial fertilization envelope from isolated components. Weidman, P.J., Shapiro, B.M. J. Cell Biol. (1987) [Pubmed]
  10. Endothelial cell membranes contain podocalyxin--the major sialoprotein of visceral glomerular epithelial cells. Horvat, R., Hovorka, A., Dekan, G., Poczewski, H., Kerjaschki, D. J. Cell Biol. (1986) [Pubmed]
  11. Electron microscopic investigation of the bladder urothelium and glycocalyx in patients with interstitial cystitis. Dixon, J.S., Holm-Bentzen, M., Gilpin, C.J., Gosling, J.A., Bostofte, E., Hald, T., Larsen, S. J. Urol. (1986) [Pubmed]
  12. Peanut lectin-binding sites in polyps of the colon and rectum. Adenomas, hyperplastic polyps, and adenomas with in situ carcinoma. Cooper, H.S., Reuter, V.E. Lab. Invest. (1983) [Pubmed]
  13. Hyaluronidase treatment of coronary glycocalyx increases reactive hyperemia but not adenosine hyperemia in dog hearts. VanTeeffelen, J.W., Dekker, S., Fokkema, D.S., Siebes, M., Vink, H., Spaan, J.A. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  14. Relationship between glycocalyx and povidone-iodine resistance in Pseudomonas aeruginosa (ATCC 27853) biofilms. Brown, M.L., Aldrich, H.C., Gauthier, J.J. Appl. Environ. Microbiol. (1995) [Pubmed]
  15. Confocal laser scanning microscopic observation of glycocalyx production by Staphylococcus aureus in skin lesions of bullous impetigo, atopic dermatitis and pemphigus foliaceus. Akiyama, H., Hamada, T., Huh, W.K., Yamasaki, O., Oono, T., Fujimoto, W., Iwatsuki, K. Br. J. Dermatol. (2003) [Pubmed]
  16. Apical barriers to airway epithelial cell gene transfer with amphotropic retroviral vectors. Wang, G., Williams, G., Xia, H., Hickey, M., Shao, J., Davidson, B.L., McCray, P.B. Gene Ther. (2002) [Pubmed]
  17. Adhesion-related glycocalyx study: quantitative approach with imaging-spectrum in the energy filtering transmission electron microscope (EFTEM). Soler, M., Desplat-Jego, S., Vacher, B., Ponsonnet, L., Fraterno, M., Bongrand, P., Martin, J.M., Foa, C. FEBS Lett. (1998) [Pubmed]
  18. Cyclic changes in human endometrial surface glycoproteins: a quantitative histochemical study. Jansen, R.P., Turner, M., Johannisson, E., Landgren, B.M., Diczfalusy, E. Fertil. Steril. (1985) [Pubmed]
  19. Characterization of a spontaneous adhesion-defective mutant of Ruminococcus albus strain 20. Mosoni, P., Gaillard-Martinie, B. Arch. Microbiol. (2001) [Pubmed]
  20. In vitro reconstitution of exocytosis from plasma membrane and isolated secretory vesicles. Crabb, J.H., Jackson, R.C. J. Cell Biol. (1985) [Pubmed]
  21. Vascular bound recombinant extracellular superoxide dismutase type C protects against the detrimental effects of superoxide radicals on endothelium-dependent arterial relaxation. Abrahamsson, T., Brandt, U., Marklund, S.L., Sjöqvist, P.O. Circ. Res. (1992) [Pubmed]
  22. Neovasculature induced by vascular endothelial growth factor is fenestrated. Roberts, W.G., Palade, G.E. Cancer Res. (1997) [Pubmed]
  23. Molecular and mechanical bases of focal lipid accumulation in arterial wall. Chien, S. Prog. Biophys. Mol. Biol. (2003) [Pubmed]
  24. Spacrcan binding to hyaluronan and other glycosaminoglycans. Molecular and biochemical studies. Chen, Q., Cai, S., Shadrach, K.G., Prestwich, G.D., Hollyfield, J.G. J. Biol. Chem. (2004) [Pubmed]
  25. The cercarial glycocalyx of Schistosoma mansoni. Samuelson, J.C., Caulfield, J.P. J. Cell Biol. (1985) [Pubmed]
  26. Cell biology of pulmonary endothelium. Ryan, U.S., Ryan, J.W. Circulation (1984) [Pubmed]
  27. Correlation of alterations in cation exchange and sarcolemmal ultrastructure produced by neuraminidase and phospholipases in cardiac cell tissue culture. Langer, G.A., Frank, J.S., Philipson, K.D. Circ. Res. (1981) [Pubmed]
  28. Platelet glycocalicin. II. Purification and characterization. Okumura, I., Lombart, C., Jamieson, G.A. J. Biol. Chem. (1976) [Pubmed]
  29. Glycocalyx of lung epithelial cells. Martins, M.d.e. .F., Bairos, V.A. Int. Rev. Cytol. (2002) [Pubmed]
  30. Crystal retention capacity of cells in the human nephron: involvement of CD44 and its ligands hyaluronic acid and osteopontin in the transition of a crystal binding- into a nonadherent epithelium. Verhulst, A., Asselman, M., Persy, V.P., Schepers, M.S., Helbert, M.F., Verkoelen, C.F., De Broe, M.E. J. Am. Soc. Nephrol. (2003) [Pubmed]
  31. Membranous expression of carcinoembryonic antigen (CEA) in the normal cervical squamous mucosa. Sanders, D.S., Stocks, S.C., Milne, D.M., Milne, G.A., Hopwood, D., Kerr, M.A. J. Pathol. (1992) [Pubmed]
  32. Mammalian reproductive tract mucins. Lagow, E., DeSouza, M.M., Carson, D.D. Hum. Reprod. Update (1999) [Pubmed]
  33. MUC1, glycans and the cell-surface barrier to embryo implantation. Aplin, J.D., Meseguer, M., Simón, C., Ortíz, M.E., Croxatto, H., Jones, C.J. Biochem. Soc. Trans. (2001) [Pubmed]
  34. Cell surface glycoconjugates and the extracellular matrix of the developing mouse embryo epicardium. Kálmán, F., Virágh, S., Módis, L. Anat. Embryol. (1995) [Pubmed]
  35. Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells. Evanko, S.P., Angello, J.C., Wight, T.N. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  36. Effect of subinhibitory concentrations of clindamycin and trospectomycin on the adherence of Staphylococcus epidermidis in an in vitro model of vascular catheter colonization. Khardori, N., Wong, E., Nguyen, H., Jeffery-Wiseman, C., Wallin, E., Tewari, R.P., Bodey, G.P. J. Infect. Dis. (1991) [Pubmed]
  37. Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release. Mochizuki, S., Vink, H., Hiramatsu, O., Kajita, T., Shigeto, F., Spaan, J.A., Kajiya, F. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  38. Generation of reactive oxygen metabolites by phagocytosing endothelial cells. Görög, P., Pearson, J.D., Kakkar, V.V. Atherosclerosis (1988) [Pubmed]
  39. Alterations in the intestinal glycocalyx and bacterial flora in response to oral indomethacin. Basivireddy, J., Jacob, M., Ramamoorthy, P., Balasubramanian, K.A. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
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