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Gene Review

Dcn  -  decorin

Mus musculus

Synonyms: Bone proteoglycan II, DC, DSPG2, Decorin, PG-S2, ...
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Disease relevance of Dcn


High impact information on Dcn

  • Toll-like receptors and T cell costimulatory molecules both trigger a DC survival pathway that is dependent on Bcl-x(L) [6].
  • Thus, signals derived from the innate and acquired immune systems control DC lifespan and immunogenicity by distinct molecular mechanisms [6].
  • To identify the genes that are differentially expressed upon maturation induced by exposure to Gram-negative bacteria, a kinetic study of DC gene expression was done with microarrays representing 11,000 genes and ESTs (expressed sequence tags) [7].
  • Resistance to Lyme disease in decorin-deficient mice [8].
  • A decorin-deficient (Dcn(-/-)) mouse was recently developed and found to have a relatively mild phenotype [8].

Chemical compound and disease context of Dcn

  • Replication-deficient adenovirus was used to deliver decorin transgene (AdDec) to the airways by a single intranasal injection in a murine bleomycin model of lung fibrosis [9].
  • Ectopic expression of the proteoglycan, decorin, abrogates the growth of experimental C6 gliomas in the rat [10].
  • Adherence of Borrelia burgdorferi. Identification of critical lysine residues in DbpA required for decorin binding [11].

Biological context of Dcn


Anatomical context of Dcn


Associations of Dcn with chemical compounds


Physical interactions of Dcn


Regulatory relationships of Dcn

  • These findings strongly suggest a new role for decorin during skeletal muscle terminal differentiation by activating TGF-beta-dependent signaling pathways [12].
  • In contrast myogenin expression was inhibited by adenovirally induced decorin expression or by adding exogenous decorin [12].
  • In both models the IGF-I receptor was up-regulated in decorin-deficient mice compared with controls and the up-regulation could not compensate the decorin deficiency in the disease models [18].
  • TIS10/PGS-2 antisense oligonucleotides also block production of PGE2 from endogenous arachidonate following endotoxin stimulation of both RAW 264.7 macrophage cells and murine peritoneal macrophages [20].
  • Our findings indicate that further improvement in the healing of muscle lacerations is attained histologically by the combined administration of IGF-1 to enhance muscle regeneration and decorin to reduce the formation of fibrosis [21].

Other interactions of Dcn

  • Chromatin immunoprecipitation assays further demonstrated that PBX proteins directly bind to the promoter of Bmp4 and Dcn in vivo in a RA-dependent fashion [22].
  • In the old mice, calcified cartilage became enriched with regard to fibromodulin, while, in contrast, decorin deposition diminished, particularly near the tidemark [23].
  • The interval mapping and test-cross results indicate that hg is not allelic with candidate genes Igf1 or decorin (Dcn), a gene that was mapped close to hg in this study [24].
  • Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray [25].
  • Especially the expression pattern of decorin and syndecan-3 coincided temporally and spatially exactly with that of OASIS [26].

Analytical, diagnostic and therapeutic context of Dcn


  1. Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Schaefer, L., Macakova, K., Raslik, I., Micegova, M., Gröne, H.J., Schönherr, E., Robenek, H., Echtermeyer, F.G., Grässel, S., Bruckner, P., Schaefer, R.M., Iozzo, R.V., Kresse, H. Am. J. Pathol. (2002) [Pubmed]
  2. Differential expression of decorin and biglycan genes during palatogenesis in normal and retinoic acid-treated mice. Zhang, Y., Mori, T., Iseki, K., Hagino, S., Takaki, H., Takeuchi, M., Hikake, T., Tase, C., Murakawa, M., Yokoya, S., Wanaka, A. Dev. Dyn. (2003) [Pubmed]
  3. Regulation of fibrillin-1 by biglycan and decorin is important for tissue preservation in the kidney during pressure-induced injury. Schaefer, L., Mihalik, D., Babelova, A., Krzyzankova, M., Gröne, H.J., Iozzo, R.V., Young, M.F., Seidler, D.G., Lin, G., Reinhardt, D.P., Schaefer, R.M. Am. J. Pathol. (2004) [Pubmed]
  4. What is the role of decorin in diabetic kidney disease? Mogyorósi, A., Ziyadeh, F.N. Nephrol. Dial. Transplant. (1999) [Pubmed]
  5. Decorin deficiency enhances progressive nephropathy in diabetic mice. Williams, K.J., Qiu, G., Usui, H.K., Dunn, S.R., McCue, P., Bottinger, E., Iozzo, R.V., Sharma, K. Am. J. Pathol. (2007) [Pubmed]
  6. A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells. Hou, W.S., Van Parijs, L. Nat. Immunol. (2004) [Pubmed]
  7. Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. Granucci, F., Vizzardelli, C., Pavelka, N., Feau, S., Persico, M., Virzi, E., Rescigno, M., Moro, G., Ricciardi-Castagnoli, P. Nat. Immunol. (2001) [Pubmed]
  8. Resistance to Lyme disease in decorin-deficient mice. Brown, E.L., Wooten, R.M., Johnson, B.J., Iozzo, R.V., Smith, A., Dolan, M.C., Guo, B.P., Weis, J.J., Höök, M. J. Clin. Invest. (2001) [Pubmed]
  9. Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin. Kolb, M., Margetts, P.J., Galt, T., Sime, P.J., Xing, Z., Schmidt, M., Gauldie, J. Am. J. Respir. Crit. Care Med. (2001) [Pubmed]
  10. TGF-beta-independent induction of immunogenicity by decorin gene transfer in human malignant glioma cells. Münz, C., Naumann, U., Grimmel, C., Rammensee, H.G., Weller, M. Eur. J. Immunol. (1999) [Pubmed]
  11. Adherence of Borrelia burgdorferi. Identification of critical lysine residues in DbpA required for decorin binding. Brown, E.L., Guo, B.P., O'Neal, P., Höök, M. J. Biol. Chem. (1999) [Pubmed]
  12. Antisense inhibition of decorin expression in myoblasts decreases cell responsiveness to transforming growth factor beta and accelerates skeletal muscle differentiation. Riquelme, C., Larrain, J., Schonherr, E., Henriquez, J.P., Kresse, H., Brandan, E. J. Biol. Chem. (2001) [Pubmed]
  13. Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. Bi, Y., Stuelten, C.H., Kilts, T., Wadhwa, S., Iozzo, R.V., Robey, P.G., Chen, X.D., Young, M.F. J. Biol. Chem. (2005) [Pubmed]
  14. Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Kolb, M., Margetts, P.J., Sime, P.J., Gauldie, J. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  15. Extensive induction of important mediators of fibrosis and dystrophic calcification in desmin-deficient cardiomyopathy. Mavroidis, M., Capetanaki, Y. Am. J. Pathol. (2002) [Pubmed]
  16. Transient up-regulation of biglycan during skeletal muscle regeneration: delayed fiber growth along with decorin increase in biglycan-deficient mice. Casar, J.C., McKechnie, B.A., Fallon, J.R., Young, M.F., Brandan, E. Dev. Biol. (2004) [Pubmed]
  17. Biglycan knockout mice: new models for musculoskeletal diseases. Young, M.F., Bi, Y., Ameye, L., Chen, X.D. Glycoconj. J. (2002) [Pubmed]
  18. Decorin, a novel player in the insulin-like growth factor system. Schönherr, E., Sunderkötter, C., Iozzo, R.V., Schaefer, L. J. Biol. Chem. (2005) [Pubmed]
  19. A novel modulatory mechanism of transforming growth factor-beta signaling through decorin and LRP-1. Cabello-Verrugio, C., Brandan, E. J. Biol. Chem. (2007) [Pubmed]
  20. Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages. Reddy, S.T., Herschman, H.R. J. Biol. Chem. (1994) [Pubmed]
  21. Improvement of muscle healing through enhancement of muscle regeneration and prevention of fibrosis. Sato, K., Li, Y., Foster, W., Fukushima, K., Badlani, N., Adachi, N., Usas, A., Fu, F.H., Huard, J. Muscle Nerve (2003) [Pubmed]
  22. Pre-B cell leukemia transcription factor (PBX) proteins are important mediators for retinoic acid-dependent endodermal and neuronal differentiation of mouse embryonal carcinoma P19 cells. Qin, P., Haberbusch, J.M., Zhang, Z., Soprano, K.J., Soprano, D.R. J. Biol. Chem. (2004) [Pubmed]
  23. Murine fibromodulin: cDNA and genomic structure, and age-related expression and distribution in the knee joint. Säämänen, A.M., Salminen, H.J., Rantakokko, A.J., Heinegård, D., Vuorio, E.I. Biochem. J. (2001) [Pubmed]
  24. Interval mapping of high growth (hg), a major locus that increases weight gain in mice. Horvat, S., Medrano, J.F. Genetics (1995) [Pubmed]
  25. Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray. Mizuno, Y., Sotomaru, Y., Katsuzawa, Y., Kono, T., Meguro, M., Oshimura, M., Kawai, J., Tomaru, Y., Kiyosawa, H., Nikaido, I., Amanuma, H., Hayashizaki, Y., Okazaki, Y. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  26. Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. Hikake, T., Mori, T., Iseki, K., Hagino, S., Zhang, Y., Takagi, H., Yokoya, S., Wanaka, A. Anat. Embryol. (2003) [Pubmed]
  27. The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. Scholzen, T., Solursh, M., Suzuki, S., Reiter, R., Morgan, J.L., Buchberg, A.M., Siracusa, L.D., Iozzo, R.V. J. Biol. Chem. (1994) [Pubmed]
  28. Immortalized, cloned mouse chondrocytic cells (MC615) produce three different matrix proteoglycans with core-protein-specific chondroitin/dermatan sulphate structures. Kokenyesi, R., Silbert, J.E. Biochem. J. (1997) [Pubmed]
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