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Gene Review

Dcn  -  decorin

Rattus norvegicus

Synonyms: Bone proteoglycan II, DSPG, Decorin, Dermatan sulfate proteoglycan-II, PG-S2, ...
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Disease relevance of Dcn


High impact information on Dcn

  • The proteoglycan decorin is a known inhibitor of TGF-beta1 [2].
  • Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney [2].
  • Decorin mRNA, in contrast to biglycan decreased and reached 20% of control on day 10 [3].
  • Since a reduction in C/EBP-beta expression does not affect the level of the ovulatory mediator prostaglandin endoperoxide synthase-2 (PGS-2), these findings support the view of C/EBP-beta as an important factor in the ovulatory process and highlight a C/EBP-beta-dependent and PGS-2-independent pathway that takes part in regulation of ovulation [6].
  • In addition, the molecular packing structure of collagen shown here provides information concerning the potential modes of action of two prominent molecules involved in human health and disease: decorin and the Matrix Metallo-Proteinase (MMP) collagenase [7].

Chemical compound and disease context of Dcn


Biological context of Dcn


Anatomical context of Dcn


Associations of Dcn with chemical compounds


Regulatory relationships of Dcn


Other interactions of Dcn


Analytical, diagnostic and therapeutic context of Dcn


  1. Role of fibrillin-1 in hypertensive and diabetic glomerular disease. Hartner, A., Schaefer, L., Porst, M., Cordasic, N., Gabriel, A., Klanke, B., Reinhardt, D.P., Hilgers, K.F. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  2. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Isaka, Y., Brees, D.K., Ikegaya, K., Kaneda, Y., Imai, E., Noble, N.A., Border, W.A. Nat. Med. (1996) [Pubmed]
  3. Altered expression of small proteoglycans, collagen, and transforming growth factor-beta 1 in developing bleomycin-induced pulmonary fibrosis in rats. Westergren-Thorsson, G., Hernnäs, J., Särnstrand, B., Oldberg, A., Heinegård, D., Malmström, A. J. Clin. Invest. (1993) [Pubmed]
  4. Spatial and temporal patterns of gene expression for the proteoglycans biglycan and decorin and for transforming growth factor-beta 1 revealed by in situ hybridization during experimentally induced liver fibrosis in the rat. Krull, N.B., Zimmermann, T., Gressner, A.M. Hepatology (1993) [Pubmed]
  5. Decorin prevents metastatic spreading of breast cancer. Reed, C.C., Waterhouse, A., Kirby, S., Kay, P., Owens, R.T., McQuillan, D.J., Iozzo, R.V. Oncogene (2005) [Pubmed]
  6. The transcription factor C/EBP-beta and its role in ovarian function; evidence for direct involvement in the ovulatory process. Pall, M., Hellberg, P., Brännström, M., Mikuni, M., Peterson, C.M., Sundfeldt, K., Nordén, B., Hedin, L., Enerbäck, S. EMBO J. (1997) [Pubmed]
  7. Microfibrillar structure of type I collagen in situ. Orgel, J.P., Irving, T.C., Miller, A., Wess, T.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  8. Kinetics of biglycan, decorin and thrombospondin-1 in mercuric chloride-induced renal tubulointerstitial fibrosis. Suzuki, K., Wang, R., Kubota, H., Shibuya, H., Saegusa, J., Sato, T. Exp. Mol. Pathol. (2005) [Pubmed]
  9. Collagen phagocytosis by fibroblasts is regulated by decorin. Bhide, V.M., Laschinger, C.A., Arora, P.D., Lee, W., Hakkinen, L., Larjava, H., Sodek, J., McCulloch, C.A. J. Biol. Chem. (2005) [Pubmed]
  10. Molecular characterization of vascular smooth muscle decorin: deduced core protein structure and regulation of gene expression. Asundi, V.K., Dreher, K.L. Eur. J. Cell Biol. (1992) [Pubmed]
  11. Airway remodeling in allergen-challenged Brown Norway rats: distribution of proteoglycans. Pini, L., Torregiani, C., Martin, J.G., Hamid, Q., Ludwig, M.S. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  12. Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. Wiberg, C., Klatt, A.R., Wagener, R., Paulsson, M., Bateman, J.F., Heinegård, D., Mörgelin, M. J. Biol. Chem. (2003) [Pubmed]
  13. Purification and characterization of a small dermatan sulphate proteoglycan implicated in the dilatation of the rat uterine cervix. Kokenyesi, R., Woessner, J.F. Biochem. J. (1989) [Pubmed]
  14. cDNA sequence for rat dermatan sulfate proteoglycan-II (decorin). Abramson, S.R., Woessner, J.F. Biochim. Biophys. Acta (1992) [Pubmed]
  15. Biglycan and decorin gene expression in normal and fibrotic rat liver: cellular localization and regulatory factors. Meyer, D.H., Krull, N., Dreher, K.L., Gressner, A.M. Hepatology (1992) [Pubmed]
  16. Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate. Kaczmarczyk, A., Thuveson, M., Fries, E. J. Biol. Chem. (2002) [Pubmed]
  17. Expression of extracellular matrix proteoglycans perlecan and decorin in carbon-tetrachloride-injured rat liver and in isolated liver cells. Gallai, M., Kovalszky, I., Knittel, T., Neubauer, K., Armbrust, T., Ramadori, G. Am. J. Pathol. (1996) [Pubmed]
  18. Luteinizing hormone induces prostaglandin endoperoxide synthase-2 and luteinization in vitro by A-kinase and C-kinase pathways. Morris, J.K., Richards, J.S. Endocrinology (1995) [Pubmed]
  19. TGF-beta 1 augments expression of the TIS10/prostaglandin synthase-2 gene in intestinal epithelial cells. Gilbert, R.S., Reddy, S.T., Targan, S., Herschman, H.R. Cell. Mol. Biol. Res. (1994) [Pubmed]
  20. Increased expression of decorin in experimental hydronephrosis. Diamond, J.R., Levinson, M., Kreisberg, R., Ricardo, S.D. Kidney Int. (1997) [Pubmed]
  21. Ex vivo transfer of the decorin gene into rat glomerulus via a mesangial cell vector suppressed extracellular matrix accumulation in experimental glomerulonephritis. Huijun, W., Long, C., Zhigang, Z., Feng, J., Muyi, G. Exp. Mol. Pathol. (2005) [Pubmed]
  22. Hepatocyte growth factor regulates proteoglycan synthesis in interstitial fibroblasts. Kobayashi, E., Sasamura, H., Mifune, M., Shimizu-Hirota, R., Kuroda, M., Hayashi, M., Saruta, T. Kidney Int. (2003) [Pubmed]
  23. Expression of a chondroitin sulfate proteoglycan, versican (PG-M), during development of rat cornea. Koga, T., Inatani, M., Hirata, A., Inomata, Y., Zako, M., Kimata, K., Oohira, A., Gotoh, T., Mori, M., Tanihara, H. Curr. Eye Res. (2005) [Pubmed]
  24. Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. Okuda, S., Languino, L.R., Ruoslahti, E., Border, W.A. J. Clin. Invest. (1990) [Pubmed]
  25. The primary calcification in bones follows removal of decorin and fusion of collagen fibrils. Hoshi, K., Kemmotsu, S., Takeuchi, Y., Amizuka, N., Ozawa, H. J. Bone Miner. Res. (1999) [Pubmed]
  26. Antiangiogenic and antifibrotic gene therapy in a chronic infusion model of peritoneal dialysis in rats. Margetts, P.J., Gyorffy, S., Kolb, M., Yu, L., Hoff, C.M., Holmes, C.J., Gauldie, J. J. Am. Soc. Nephrol. (2002) [Pubmed]
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