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Gene Review:

CD4 - CD4 molecule

Bos taurus

Hunáková, L. et al., Handa, A. et al., Chieco-Bianchi, L. et al.

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Disease relevance of cd4

Four kinds of gangliosides, namely GM1a, GD1a, GD1b and GT1b and their sulfated derivatives were examined for antiviral activities against human immunodeficiency virus type 1 and abilities to modulate CD4 antigen on the cell surface [1].

High impact information on cd4

The addition of monosialoganglioside GM1 to serum-free culture medium efficiently and specifically inhibited CD4 antigen expression on normal T lymphocytes from peripheral blood or thymus as well as on cells from H9 and Molt-3 lines; other molecules such as CD3, CD2 and CD8 were not affected [2].
Down-regulation of the CD4 antigen was partially inhibited by the isoquinoline protein kinase inhibitor H7 and unaffected by the calmodulin inhibitor R24571 (calmidazolium) [3].
Phorbol ester (PMA) induced decrease in cell surface expression of CD4 antigen was potentiated on human monoblastoid cell line U-937 cultured and induced in protein-free culture medium [3].

Analytical, diagnostic and therapeutic context of cd4

The CD4 antigen on the surface of T cells became hardly detectable after treatment with them [1].

References

Inhibition of infection with human immunodeficiency virus type 1 by sulfated gangliosides. Handa, A., Hoshino, H., Nakajima, K., Adachi, M., Ikeda, K., Achiwa, K., Itoh, T., Suzuki, Y. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
CD4 modulation and inhibition of HIV-1 infectivity induced by monosialoganglioside GM1 in vitro. Chieco-Bianchi, L., Calabrò, M.L., Panozzo, M., De Rossi, A., Amadori, A., Callegaro, L., Siccardi, A. AIDS (1989) [Pubmed]
Phorbol ester-induced modulation of cell surface antigens on U-937 cells in protein-free medium: effect of protein kinase and calmodulin inhibitors. Hunáková, L., Sedlák, J., Chorváth, B. Neoplasma (1993) [Pubmed]

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