Gene Review:
Cd4 - CD4 antigen
Mus musculus
Synonyms:
L3T4, Ly-4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4
- Role of L3T4 antigen in the activation of various functions of Lyt-1+2- T cells against vaccinia virus. Aoyama, A., Yoshioka, T., Sato, S., Mizushima, Y., Ogata, M., Ueda, S., Kato, S., Fujiwara, H., Hamaoka, T. Microbiol. Immunol. (1986)
- A subset of T cell receptors associated with L3T4 molecules mediates C6VL leukemia cell binding of its cognate retrovirus. O'Neill, H.C., McGrath, M.S., Allison, J.P., Weissman, I.L. Cell (1987)
- Alpha/beta T-cell antigen receptor gene and protein expression occurs at early stages of thymocyte differentiation. Richie, E.R., McEntire, B., Crispe, N., Kimura, J., Lanier, L.L., Allison, J.P. Proc. Natl. Acad. Sci. U.S.A. (1988)
- MHC-unrestricted transfer of antilisterial immunity by freshly isolated immune CD8 spleen cells. Lukacs, K., Kurlander, R.J. J. Immunol. (1989)
- Modulation of murine schistosomiasis by exogenously administered prostaglandins. Chensue, S.W., Remick, D.G., Higashi, G.I., Boros, D.L., Kunkel, S.L. Am. J. Pathol. (1986)
- Isolation of two early B lymphocyte progenitors from mouse marrow: a committed pre-pre-B cell and a clonogenic Thy-1-lo hematopoietic stem cell. Muller-Sieburg, C.E., Whitlock, C.A., Weissman, I.L. Cell (1986)
- A novel receptor involved in T-cell activation. Cocks, B.G., Chang, C.C., Carballido, J.M., Yssel, H., de Vries, J.E., Aversa, G. Nature (1995)
- Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Brenneman, D.E., Westbrook, G.L., Fitzgerald, S.P., Ennist, D.L., Elkins, K.L., Ruff, M.R., Pert, C.B. Nature (1988)
- Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes. Havran, W.L., Poenie, M., Kimura, J., Tsien, R., Weiss, A., Allison, J.P. Nature (1987)
- Immunotherapy for myasthenia gravis: a murine model. Christadoss, P., Dauphinee, M.J. J. Immunol. (1986)
- Adoptive immunity to Mycobacterium bovis strain bacillus Calmette-Guérin by long-term cultured T-cell line in nude mice. Yamamoto, S., Iwai, H., Ueda, K. Immunology (1989)
- Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain. Tourvieille, B., Gorman, S.D., Field, E.H., Hunkapiller, T., Parnes, J.R. Science (1986)
- Structure of the mouse gene encoding CD4 and an unusual transcript in brain. Gorman, S.D., Tourvieille, B., Parnes, J.R. Proc. Natl. Acad. Sci. U.S.A. (1987)
- The gene encoding the mouse T cell differentiation antigen L3T4 is located on chromosome 6. Field, E.H., Tourvieille, B., D'Eustachio, P., Parnes, J.R. J. Immunol. (1987)
- Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cells. Lechler, R.I., Norcross, M.A., Germain, R.N. J. Immunol. (1985)
- Monoallelic expression of mouse Cd4 gene. Capparelli, R., Costabile, A., Viscardi, M., Iannelli, D. Mamm. Genome (2004)
- Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells. Ceredig, R., Lowenthal, J.W., Nabholz, M., MacDonald, H.R. Nature (1985)
- CD4 is expressed on murine pluripotent hematopoietic stem cells. Wineman, J.P., Gilmore, G.L., Gritzmacher, C., Torbett, B.E., Müller-Sieburg, C.E. Blood (1992)
- Abnormal expression of T cell receptor genes in Lyt-2- L3T4- lymphocytes of lpr mice: comparison with normal immature thymocytes. Miescher, G.C., Budd, R.C., Lees, R.K., MacDonald, H.R. J. Immunol. (1987)
- The surface phenotype of activated T lymphocytes. Kelly, K., Shortman, K., Scollay, R. Immunol. Cell Biol. (1988)
- Autocytotoxic activity of lymphokine-activated killer cells: characterization of effector cells and susceptible targets. Suzuki, H., Ikemoto, M., Kamitani, T., Hoshino, K., Yano, S. Anticancer Res. (1989)
- In vitro proliferation of murine spleen cells: inhibition by monoclonal antibodies to L3T4 and Lyt-2 T cell markers or intracellular cyclic adenosine monophosphate. Zhou, P., Gorzynski, T., Dowjat, W.K., Rabin, R., Zaleski, M.B. Exp. Cell Biol. (1989)
- The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacterium tuberculosis. Orme, I.M. J. Immunol. (1987)
- Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation. Effects of 17 beta-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor. Screpanti, I., Morrone, S., Meco, D., Santoni, A., Gulino, A., Paolini, R., Crisanti, A., Mathieson, B.J., Frati, L. J. Immunol. (1989)
- Role of L3T4 in antigen-driven activation of a class I-specific T cell hybridoma. Greenstein, J.L., Malissen, B., Burakoff, S.J. J. Exp. Med. (1985)
- Accessory molecules in T lymphocyte activation. Miller, J.F. Int. Arch. Allergy Appl. Immunol. (1987)
- Specific lymphocyte-target cell conjugate formation between tumor-specific helper T-cell hybridomas and IA-bearing RCS tumors and IE-bearing allogeneic cells. I. Role of Ia and both L3T4 and LFA-1 antigens in recognition/binding. Ohnishi, K., Bonavida, B. J. Immunol. (1986)
- Administration of interleukin-2 induces major histocompatibility complex class II expression on the biliary epithelial cells, possibly through endogenous interferon-gamma production. Himeno, H., Saibara, T., Onishi, S., Yamamoto, Y., Enzan, H. Hepatology (1992)
- Functional analysis of T cell subsets from mice bearing the lpr gene. Davignon, J.L., Budd, R.C., Ceredig, R., Piguet, P.F., MacDonald, H.R., Cerottini, J.C., Vassalli, P., Izui, S. J. Immunol. (1985)
- The role of accessory molecules in T-helper activation induced by antigen, lectin, or CD3 antibodies. Torbett, B.E., Clark, W.R. Cell. Immunol. (1988)
- Contact-mediated maturational effects of thymic stromal cells on murine thymocytes in culture. Savion, S., Itoh, T., Hertogs, H., Shoham, J. Immunology (1989)
- In vitro properties of murine autoreactive T cell clones with specificity for erythrocytes. Gibson, J., Basten, A. Autoimmunity (1988)
- Proliferation in vitro and interleukin production by 14 day fetal and adult Lyt-2-/L3T4- mouse thymocytes. Ceredig, R. J. Immunol. (1986)
- Morphological analysis of selective destruction of pancreatic beta-cells by cytotoxic T lymphocytes in NOD mice. Hayakawa, M., Yokono, K., Nagata, M., Hatamori, N., Ogawa, W., Miki, A., Mizoguti, H., Baba, S. Diabetes (1991)
- Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule. Dialynas, D.P., Quan, Z.S., Wall, K.A., Pierres, A., Quintáns, J., Loken, M.R., Pierres, M., Fitch, F.W. J. Immunol. (1983)