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Chemical Compound Review

Monosialosyl tetraglycosyl ceramide     (2S,4S,5R,6S)-5-acetamido-2- [(2R,3R,4R,5S...

Synonyms: Ganglioside A2, Ganglioside GI, Ganglioside M1, AC1NUZHU, GM1a, ...
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Disease relevance of Monosialosyl tetraglycosyl ceramide


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Chemical compound and disease context of Monosialosyl tetraglycosyl ceramide


Biological context of Monosialosyl tetraglycosyl ceramide


Anatomical context of Monosialosyl tetraglycosyl ceramide


Associations of Monosialosyl tetraglycosyl ceramide with other chemical compounds


Gene context of Monosialosyl tetraglycosyl ceramide


Analytical, diagnostic and therapeutic context of Monosialosyl tetraglycosyl ceramide


  1. Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals. Kakinoki, B., Sekimoto, S., Yuki, S., Ohgami, T., Sejima, M., Yamagami, K., Saito, K. Diabetes (2006) [Pubmed]
  2. GM1 binding-deficient exotoxin is a potent noninflammatory broad spectrum intradermal immunoadjuvant. Zoeteweij, J.P., Epperson, D.E., Porter, J.D., Zhang, C.X., Frolova, O.Y., Constantinides, A.P., Fuhrmann, S.R., El-Amine, M., Tian, J.H., Ellingsworth, L.R., Glenn, G.M. J. Immunol. (2006) [Pubmed]
  3. CD4 modulation and inhibition of HIV-1 infectivity induced by monosialoganglioside GM1 in vitro. Chieco-Bianchi, L., Calabrò, M.L., Panozzo, M., De Rossi, A., Amadori, A., Callegaro, L., Siccardi, A. AIDS (1989) [Pubmed]
  4. Failure of GM1 ganglioside to influence outcome in experimental focal ischemia. Mayer, S.A., Pulsinelli, W.A. Stroke (1992) [Pubmed]
  5. GM1 ganglioside prevents seizures, Na+,K+-ATPase activity inhibition and oxidative stress induced by glutaric acid and pentylenetetrazole. Fighera, M.R., Royes, L.F., Furian, A.F., Oliveira, M.S., Fiorenza, N.G., Frussa-Filho, R., Petry, J.C., Coelho, R.C., Mello, C.F. Neurobiol. Dis. (2006) [Pubmed]
  6. A double-blind, placebo-controlled crossover study of ganglioside GM1 treatment for Alzheimer's disease. Flicker, C., Ferris, S.H., Kalkstein, D., Serby, M. The American journal of psychiatry. (1994) [Pubmed]
  7. Effect of ganglioside (GM1) on memory in senescent rats. Silva, R.H., Felicio, L.F., Nasello, A.G., Vital, M.A., Frussa-Filho, R. Neurobiol. Aging (1996) [Pubmed]
  8. Effects of monosialoganglioside GM1 on scopolamine-induced amnesia. Bellot, R.G., Silva, R.H., Frussa-Filho, R. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  9. Ganglioside GM1 binds to the Trk protein and regulates receptor function. Mutoh, T., Tokuda, A., Miyadai, T., Hamaguchi, M., Fujiki, N. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  10. Direct evidence that ganglioside is an integral component of the thyrotropin receptor. Kielczynski, W., Harrison, L.C., Leedman, P.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  11. Endocytosis of cholera toxin into neuronal GERL. Joseph, K.C., Kim, S.U., Stieber, A., Gonatas, N.K. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  12. The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of amyloid beta-peptide from liposomes prepared from brain membrane-like lipids. Tashima, Y., Oe, R., Lee, S., Sugihara, G., Chambers, E.J., Takahashi, M., Yamada, T. J. Biol. Chem. (2004) [Pubmed]
  13. The synthetic ceramide analog L-PDMP partially protects striatal dopamine levels but does not promote dopamine neuron survival in murine models of parkinsonism. Schneider, J.S., Bradbury, K.A., Anada, Y., Inokuchi, J., Anderson, D.W. Brain Res. (2006) [Pubmed]
  14. Taurine-induced neuronal differentiation: the influence of calcium and the ganglioside GM1. Spoerri, P.E., Caple, C.G., Roisen, F.J. Int. J. Dev. Neurosci. (1990) [Pubmed]
  15. Biomimetic particles for isolation and reconstitution of receptor function. Moura, S.P., Carmona-Ribeiro, A.M. Cell Biochem. Biophys. (2006) [Pubmed]
  16. Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transport. Gorria, M., Huc, L., Sergent, O., Rebillard, A., Gaboriau, F., Dimanche-Boitrel, M.T., Lagadic-Gossmann, D. Biochem. Pharmacol. (2006) [Pubmed]
  17. Gangliosides and regeneration of the goldfish optic nerve in vivo and in vitro. Rahmann, H., Rösner, H., Sonnentag, U., Esders, S. Neurochem. Int. (1992) [Pubmed]
  18. Potentiation of nerve growth factor-induced alterations in cholinergic fibre length and presynaptic terminal size in cortex of lesioned rats by the monosialoganglioside GM1. Garofalo, L., Ribeiro-da-Silva, A., Cuello, A.C. Neuroscience (1993) [Pubmed]
  19. Synthetic peptides from the principal neutralizing domain of human immunodeficiency virus type 1 (HIV-1) enhance HIV-1 infection through a CD4-dependent mechanism. De Rossi, A., Pasti, M., Mammano, F., Panozzo, M., Dettin, M., Di Bello, C., Chieco-Bianchi, L. Virology (1991) [Pubmed]
  20. Evidence for the functional role of monosialoganglioside GM1 in synaptic transmission in the rat hippocampus. Wieraszko, A., Seifert, W. Brain Res. (1986) [Pubmed]
  21. Triggering of a sustained calcium response through a p56lck-dependent pathway by exogenous ganglioside GM1 in human T lymphocytes. Gouy, H., Debré, P., Bismuth, G. J. Immunol. (1995) [Pubmed]
  22. Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors. Ferrari, G., Anderson, B.L., Stephens, R.M., Kaplan, D.R., Greene, L.A. J. Biol. Chem. (1995) [Pubmed]
  23. Ricin-membrane interaction: membrane penetration depth by fluorescence quenching and resonance energy transfer. Ramalingam, T.S., Das, P.K., Podder, S.K. Biochemistry (1994) [Pubmed]
  24. Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve. Choi, J.S., Kim, J.A., Joo, C.K. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  25. Recombinant human ciliary neurotrophic factor alters the threshold of hippocampal pyramidal neuron sensitivity to excitotoxin damage: synergistic effects of monosialogangliosides. Skaper, S.D., Negro, A., Dal Toso, R., Facci, L. J. Neurosci. Res. (1992) [Pubmed]
  26. Inhibition of high affinity choline uptake in the rat brain by neurotoxins: effect of monosialoganglioside GM1. Maysinger, D., Leavitt, B.R., Zorc, B., Butula, I., Fernandes, L.G., Ribeiro-da-Silva, A. Neurochem. Int. (1992) [Pubmed]
  27. Tryptophan fluorescence properties of cholera toxin upon interacting with ganglioside GD1b. Mestrallet, M.G., Bennun, F.R., Maggio, B., Cumar, F.A. J. Neurosci. Res. (1984) [Pubmed]
  28. Brain-derived neurotrophic factor selectively rescues mesencephalic dopaminergic neurons from 2,4,5-trihydroxyphenylalanine-induced injury. Skaper, S.D., Negro, A., Facci, L., Dal Toso, R. J. Neurosci. Res. (1993) [Pubmed]
  29. Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells. Huang, P., Xu, W., Yoon, S.I., Chen, C., Chong, P.L., Liu-Chen, L.Y. Biochem. Pharmacol. (2007) [Pubmed]
  30. Monosialoganglioside protected ischemic rat hippocampal slices through stabilizing expression of N-methyl-D-aspartate receptor subunit. Liu, J.R., Ding, M.P., Wei, E.Q., Huang, J.Z., Song, Y., Ding, Q., Ge, Q.F. Acta Pharmacol. Sin. (2004) [Pubmed]
  31. Cutting edge: the mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues. van Ginkel, F.W., Jackson, R.J., Yuki, Y., McGhee, J.R. J. Immunol. (2000) [Pubmed]
  32. Hypoxic-ischemic damage and the neuroprotective effects of GM1 ganglioside. Leon, A., Lipartiti, M., Seren, M.S., Lazzaro, A., Mazzari, S., Koga, T., Toffano, G., Skaper, S.D. Stroke (1990) [Pubmed]
  33. Protective effects of a monosialoganglioside derivative following transitory forebrain ischemia in rats. Seren, M.S., Rubini, R., Lazzaro, A., Zanoni, R., Fiori, M.G., Leon, A. Stroke (1990) [Pubmed]
  34. A 9 A two-dimensional projected structure of cholera toxin B-subunit-GM1 complexes determined by electron crystallography. Mosser, G., Mallouh, V., Brisson, A. J. Mol. Biol. (1992) [Pubmed]
  35. Monosialoganglioside GM1 reduces ischemia--reperfusion-induced injury in the rat retina. Weber, M., Mohand-Said, S., Hicks, D., Dreyfus, H., Sahel, J.A. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  36. GM1 ganglioside attenuates the behavioral deficits but not the granule cell damage produced by intradentate colchicine. Walsh, T.J., Emerich, D.F., Schmechel, D.E. Brain Res. (1989) [Pubmed]
  37. In vitro evaluation of nanoparticle formulations containing gangliosides. Polato, L., Benedetti, L.M., Callegaro, L., Couvreur, P. Journal of drug targeting. (1994) [Pubmed]
  38. Post-injury treatment with GM1 ganglioside reduces nociceptive behaviors and spinal cord metabolic activity in rats with experimental peripheral mononeuropathy. Mao, J., Hayes, R.L., Price, D.D., Coghill, R.C., Lu, J., Mayer, D.J. Brain Res. (1992) [Pubmed]
  39. The role of the monosialoganglioside, GM1 as a neuroprotectant in an experimental model of cardiopulmonary bypass and hypothermic circulatory arrest. Baumgartner, W.A., Redmond, J.M., Zehr, K.J., Brock, M.V., Tseng, E.E., Blue, M.E., Troncoso, J.C., Johnston, M.V. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
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