High impact information on Poxm

• The five known Drosophila paired domains fall into three classes: (i) the prd,gsb-class, (ii) the Pox meso, undulated-class and (iii) the Pox neuro-class which probably includes the paired domain of the murine gene Pax 2 [1].
• Both Pox meso and undulated are expressed in tissues derived from the somatic mesoderm [1].
• Other sites of expression include the meso- and metanephros, lens, olfactory bulbs, heart, primitive streak and the genital tubercle [2].
• The function of P29 in mitochondria and the possible interaction with JHE are discussed [3].
• An immunoreactive protein of 50kDa in the hemolymph does not result from alternative splicing of CG3776 but may result from dimerization of P29 [3].

Biological context of Poxm

• While no mutant phenotypes of Pox meso and Pox neuro have yet been discovered, a murine gene with a paired domain closely homologous to that of Pox meso has recently been identified with the undulated mutant [1].
• P29 mRNA and an immunoreactive protein of 25kDa were detected in Drosophila larvae, pupae and adults [3].
• A putative juvenile hormone esterase (JHE) binding protein, P29, was isolated from the tobacco hornworm Manduca sexta [J. Biol. Chem. 275(3), 1802-1806] [3].

Anatomical context of Poxm

• Drosophila P29 is predicted to localize to mitochondria (MitoProt; 93% probability) and has a 6kDa N-terminal targeting sequence [3].

Other interactions of Poxm

• Two new paired domain genes of Drosophila, Pox meso and Pox neuro, are described [1].

Analytical, diagnostic and therapeutic context of Poxm

• A homolog of P29 was identified in Drosophila melanogaster by sequence alignment [3].

References