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Gene Review

DppIII  -  Dipeptidyl aminopeptidase III

Drosophila melanogaster

Synonyms: CG7415, DPP, DPP III, Dipeptidyl arylamidase III, Dipeptidyl peptidase 3, ...
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High impact information on DppIII

  • These results constitute the first characterization of an evolutionarily conserved insect DPP III that is expressed as a cytosolic and a membrane peptidase involved in proctolin degradation [1].
  • Immunocytochemical studies using anti-(rat liver DPP III) Ig indicated the expression of this putative DPP III at the outer cell membrane and into the cytosol of transfected cells [1].
  • From analysis of the Drosophila genome sequence database, it was possible to identify a putative DPP sharing high homology with the sequences obtained from the cockroach purified proteins and with the rat DPP III [2].
  • Dipeptidyl-peptidase III (DPP III) hydrolyses small peptides with a broad substrate specificity [3].

Biological context of DppIII

  • In addition, low concentration of the specific DPP III inhibitor tynorphin prevented proctolin degradation (IC50 = 0.62 +/- 0.15 micro m) [1].

Anatomical context of DppIII


Analytical, diagnostic and therapeutic context of DppIII

  • In addition, with a probe specific for D. melanogaster DPP III, northern blot analysis of fruit fly total RNA showed two transcripts at approximately 2.6 and 2.3 kb, consistent with the translation of 89-kDa and 82-kDa DPP III proteins [3].


  1. Characterization of a functionally expressed dipeptidyl aminopeptidase III from Drosophila melanogaster. Mazzocco, C., Fukasawa, K.M., Auguste, P., Puiroux, J. Eur. J. Biochem. (2003) [Pubmed]
  2. Purification, partial sequencing and characterization of an insect membrane dipeptidyl aminopeptidase that degrades the insect neuropeptide proctolin. Mazzocco, C., Fukasawa, K.M., Raymond, A.A., Puiroux, J. Eur. J. Biochem. (2001) [Pubmed]
  3. Identification and characterization of two dipeptidyl-peptidase III isoforms in Drosophila melanogaster. Mazzocco, C., Gillibert-Duplantier, J., Neaud, V., Fukasawa, K.M., Claverol, S., Bonneu, M., Puiroux, J. FEBS J. (2006) [Pubmed]
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