The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Dpp3  -  dipeptidylpeptidase 3

Rattus norvegicus

Synonyms: DPP III, Dipeptidyl aminopeptidase III, Dipeptidyl arylamidase III, Dipeptidyl peptidase 3, Dipeptidyl peptidase III, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dpp3

  • Each mutated cDNA was expressed in E. coli (BL21), and each expressed DPP III was purified to apparent homogeneity on SDS-polyacrylamide gel electrophoresis [1].

High impact information on Dpp3

  • Dipeptidyl-aminopeptidase III of rat brain. Selective affinity for enkephalin and angiotensin [2].
  • The recoveries of the enzyme activities by the addition of various metal ions to apo-DPP III were also measured, and Co(2+), Ni(2+), and Cu(2+) ions completely recovered the enzyme activities as did Zn(2+) [3].
  • All of these data suggest that the donor set and the coordination geometry of the metal ions in DPP III, which has the HExxxH motif as the metal binding site, are very similar to those of the metal ions in thermolysin, which has the HExxH motif [3].
  • The role of the HELLGH (residues 450-455) motif in the sequence of rat dipeptidyl peptidase III (EC was investigated by replacing Glu451 with an alanine or an aspartic acid residue and by replacing His450 and His455 with a tyrosine residue by site-directed mutagenesis [4].
  • Arylamidase, dipeptidyl peptidase III and most of the leucine aminopeptidase could be extracted from the muscle with a neutral salt solution, but dipeptidyl peptidase I was extracted only in the presence of Triton X-100; dipeptidyl peptidase II showed an intermediate extraction behaviour [5].

Biological context of Dpp3


Anatomical context of Dpp3

  • A search of databases revealed a high similarity between the human erythrocyte and rat liver DPP III: 21 matches out of 34 detected peptides were found, covering 40% of the total sequence [8].
  • The DPP III antigen was detected in significant amounts in the cytosol of various rat tissues by immunohistochemical examination [6].

Associations of Dpp3 with chemical compounds


Analytical, diagnostic and therapeutic context of Dpp3


  1. Alteration of rat dipeptidyl peptidase III by site-directed mutagenesis: cysteine(176) is a regulatory residue for the enzyme activity. Li, Y.H., Maeda, T., Yamane, T., Ohkubo, I. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. Dipeptidyl-aminopeptidase III of rat brain. Selective affinity for enkephalin and angiotensin. Lee, C.M., Snyder, S.H. J. Biol. Chem. (1982) [Pubmed]
  3. Characterization of the metal-substituted dipeptidyl peptidase III (rat liver). Hirose, J., Iwamoto, H., Nagao, I., Enmyo, K., Sugao, H., Kanemitu, N., Ikeda, K., Takeda, M., Inoue, M., Ikeda, T., Matsuura, F., Fukasawa, K.M., Fukasawa, K. Biochemistry (2001) [Pubmed]
  4. The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme. Fukasawa, K., Fukasawa, K.M., Iwamoto, H., Hirose, J., Harada, M. Biochemistry (1999) [Pubmed]
  5. Separation of rat muscle aminopeptidases. Parsons, M.E., Pennington, R.J. Biochem. J. (1976) [Pubmed]
  6. Dipeptidyl peptidase III from rat liver cytosol: purification, molecular cloning and immunohistochemical localization. Ohkubo, I., Li, Y.H., Maeda, T., Yamamoto, Y., Yamane, T., Du, P.G., Nishi, K. Biol. Chem. (1999) [Pubmed]
  7. Molecular cloning and immunohistochemical localization of rat dipeptidyl peptidase III. Ohkubo, I., Li, Y., Maeda, T., Yamamoto, Y., Yamane, T., Du, P.G., Nishi, K. Forensic Sci. Int. (2000) [Pubmed]
  8. Human and rat dipeptidyl peptidase III: biochemical and mass spectrometric arguments for similarities and differences. Abramić, M., Schleuder, D., Dolovcak, L., Schröder, W., Strupat, K., Sagi, D., Peter-Katalini, J., Vitale, L. Biol. Chem. (2000) [Pubmed]
WikiGenes - Universities