High impact information on RAB5C

• The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes [1].
• Rab5 is a small GTPase that controls endocytosis and early endosome dynamics [2].
• The small GTPase Rac has previously been shown to be involved downstream of PI3-kinase in the reorganization of actin filaments [3].
• The deduced amino acid sequence shows the highest amino acid identity (79%) with the Drosophila ARF-like protein 1 (dArl1) among all the known members of the ras-like small GTPase superfamily [4].
• Because the small GTPase Rho is a key regulator of MLC phosphorylation, we investigated 1) whether Rho is activated by hyperosmotic stress, and if so, what the triggering factors are, and 2) whether the Rho/Rho kinase (ROK) pathway is involved in MLC phosphorylation and NKCC activation [5].

Biological context of RAB5C

• Small GTPase Rho and its target Rho-kinase/ROK/ROCK play an important role in various cellular functions, including smooth muscle contraction, actin cytoskeleton organization, and cell adhesion and migration, all of which may be involved in the pathogenesis of arteriosclerosis [6].

Associations of RAB5C with chemical compounds

• These events were inhibited by GDP-beta-S and promoted by lysophosphatidic acid (LPA) and GTP-gamma-S, a small GTPase inhibitor and two activators, respectively [7].

References