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Gene Review

RAB5C  -  RAB5C, member RAS oncogene family

Sus scrofa

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High impact information on RAB5C


Biological context of RAB5C

  • Small GTPase Rho and its target Rho-kinase/ROK/ROCK play an important role in various cellular functions, including smooth muscle contraction, actin cytoskeleton organization, and cell adhesion and migration, all of which may be involved in the pathogenesis of arteriosclerosis [6].

Associations of RAB5C with chemical compounds


  1. The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes. Marzesco, A.M., Galli, T., Louvard, D., Zahraoui, A. J. Biol. Chem. (1998) [Pubmed]
  2. Visualization of Rab5 activity in living cells by FRET microscopy and influence of plasma-membrane-targeted Rab5 on clathrin-dependent endocytosis. Galperin, E., Sorkin, A. J. Cell. Sci. (2003) [Pubmed]
  3. PDGF induces reorganization of vimentin filaments. Valgeirsdóttir, S., Claesson-Welsh, L., Bongcam-Rudloff, E., Hellman, U., Westermark, B., Heldin, C.H. J. Cell. Sci. (1998) [Pubmed]
  4. The mammalian ARF-like protein 1 (Arl1) is associated with the Golgi complex. Lowe, S.L., Wong, S.H., Hong, W. J. Cell. Sci. (1996) [Pubmed]
  5. Hyperosmotic stress activates Rho: differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation. Di Ciano-Oliveira, C., Sirokmány, G., Szászi, K., Arthur, W.T., Masszi, A., Peterson, M., Rotstein, O.D., Kapus, A. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  6. Adenovirus-mediated transfer of dominant-negative rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo. Morishige, K., Shimokawa, H., Eto, Y., Kandabashi, T., Miyata, K., Matsumoto, Y., Hoshijima, M., Kaibuchi, K., Takeshita, A. Arterioscler. Thromb. Vasc. Biol. (2001) [Pubmed]
  7. Actin polymerization in the equatorial and postacrosomal regions of guinea pig spermatozoa during the acrosome reaction is regulated by G proteins. Delgado-Buenrostro, N.L., Hernández-González, E.O., Segura-Nieto, M., Mújica, A. Mol. Reprod. Dev. (2005) [Pubmed]
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