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Gene Review:

CLDN1 - claudin 1

Bos taurus

Graham, C. et al., Boveri, M. et al., Jin, M. et al., Lockman, P.R. et al.

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High impact information on CLDN1

After 6 hours of treatment with HGF, occludin, claudin-1, and beta-catenin were redistributed from the membrane to the cytoplasm [1].
Immunocytochemistry analysis revealed no evident changes in the distribution of the cytoskeleton protein F-actin and tight junction proteins occludin and claudin after lipoteichoic acid treatment [2].
Expression of connexin 43, an integral component of gap junctions, the tight-junction molecules claudin-1 and zonula occludens 1 (ZO-1), and the catalytic alpha-subunit of Na(+)-K(+)-ATPase was demonstrated by SDS-PAGE and Western blotting [3].
Both claudin-1 and ZO-1 immunostaining showed plasma membrane staining, which was present at the stratum granulosum with decreasing intensity through the stratum spinosum to the stratum basale [3].

Analytical, diagnostic and therapeutic context of CLDN1

Western blot analyses of occludin and claudin-1 confirmed no protein expression changes with incubation of either nanoparticle [4].

References

Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Jin, M., Barron, E., He, S., Ryan, S.J., Hinton, D.R. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
Highly purified lipoteichoic acid from gram-positive bacteria induces in vitro blood-brain barrier disruption through glia activation: role of pro-inflammatory cytokines and nitric oxide. Boveri, M., Kinsner, A., Berezowski, V., Lenfant, A.M., Draing, C., Cecchelli, R., Dehouck, M.P., Hartung, T., Prieto, P., Bal-Price, A. Neuroscience (2006) [Pubmed]
Functional organization of the bovine rumen epithelium. Graham, C., Simmons, N.L. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2005) [Pubmed]
In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles. Lockman, P.R., Koziara, J., Roder, K.E., Paulson, J., Abbruscato, T.J., Mumper, R.J., Allen, D.D. Pharm. Res. (2003) [Pubmed]

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CLDN1	Canis lupus familiaris
cldn1	Danio rerio
CLDN1	Gallus gallus
CLDN1	Homo sapiens
CLDN1	Macaca mulatta
Cldn1	Mus musculus
CLDN1	Pan troglodytes
Cldn1	Rattus norvegicus
cldn1	Xenopus (Silurana) tropicalis

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