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Gene Review:

Su(var)3-7 - Suppressor of variegation 3-7

Drosophila melanogaster

Synonyms: CG8599, DmSu(var)3-7, Dmel\CG8599, Protein suppressor of variegation 3-7, SU(VAR)3-7, ...

Delattre, M. et al., Spierer, A. et al., Delattre, M. et al., Cléard, F. et al., Jaquet, Y. et al., et al.

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High impact information on Su(var)3-7

The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers [1].
The silencing responds to the loss of a dose of the dominant modifiers of position-effect variegation Su(var)3-7 and Su(var)2-5, the locus encoding HP1 [2].
In polytene chromosomes deprived of Su(var)3-7, we observe a specific bloating of the male X chromosome, leading to shortening of the chromosome and to blurring of its banding pattern [3].
Finally, bloating of the male X chromosome in the Su(var)3-7 mutant depends on the presence of a functional dosage compensation complex on this chromosome [3].
Increased expression of Drosophila Su(var)3-7 triggers Su(var)3-9-dependent heterochromatin formation [4].

Biological context of Su(var)3-7

Here we show that the product of Su(var)3-7 is a nuclear protein which associates with pericentromeric heterochromatin at interphase, whether on diploid chromosomes from embryonic nuclei or on polytene chromosomes from larval salivary glands [5].
In addition, Su(var)3-7 was found over the complete length of all chromosomes [4].
The N-terminus of the Ravus protein contains only one of the seven unusual zinc fingers of Su(var)3-7 [6].
The triplet coding for the N-terminus amino acid of the new gene lies only 368 base pairs from the start of transcription of Su(var)3-7 [6].
Together with Su(var)2-5 and Su(var)3-7, Su(var)3-9 belongs to the group of haplo-suppressor loci which show a triplo-dependent enhancer effect [7].

Associations of Su(var)3-7 with chemical compounds

The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box [8].

Regulatory relationships of Su(var)3-7

Conferring a function to each of the conserved motives allows us to better understand the mode of action of SU(VAR)3-7 in triggering heterochromatin formation and subsequent genomic silencing [9].

Other interactions of Su(var)3-7

These two features are strictly dependent on the histone-methyltransferase Su(var)3-9, whereas the generalised localisation of Su(var)3-7 is not [4].
A new gene in Drosophila melanogaster, Ravus, the phantom of the modifier of position-effect variegation Su(var)3-7 [6].
The suppressor locus Su-var(3)14 maps in 86CD, Su-var(3)13 in 86F4-7, Su-var(3)6 in 87B4-7 and Su-var(3)7 in 87E4-5 [10].

Analytical, diagnostic and therapeutic context of Su(var)3-7

Functional dissection of the Drosophila modifier of variegation Su(var)3-7 [11].

References

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. Reuter, G., Giarre, M., Farah, J., Gausz, J., Spierer, A., Spierer, P. Nature (1990) [Pubmed]
Ectopic HP1 promotes chromosome loops and variegated silencing in Drosophila. Seum, C., Delattre, M., Spierer, A., Spierer, P. EMBO J. (2001) [Pubmed]
Loss of the modifiers of variegation Su(var)3-7 or HP1 impacts male X polytene chromosome morphology and dosage compensation. Spierer, A., Seum, C., Delattre, M., Spierer, P. J. Cell. Sci. (2005) [Pubmed]
Increased expression of Drosophila Su(var)3-7 triggers Su(var)3-9-dependent heterochromatin formation. Delattre, M., Spierer, A., Jaquet, Y., Spierer, P. J. Cell. Sci. (2004) [Pubmed]
SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. Cléard, F., Delattre, M., Spierer, P. EMBO J. (1997) [Pubmed]
A new gene in Drosophila melanogaster, Ravus, the phantom of the modifier of position-effect variegation Su(var)3-7. Delattre, M., Spierer, A., Hulo, N., Spierer, P. Int. J. Dev. Biol. (2002) [Pubmed]
SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing. Schotta, G., Ebert, A., Reuter, G. Genetica (2003) [Pubmed]
The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box. Cléard, F., Matsarskaia, M., Spierer, P. Nucleic Acids Res. (1995) [Pubmed]
Conserved domains control heterochromatin localization and silencing properties of SU(VAR)3-7. Jaquet, Y., Delattre, M., Montoya-Burgos, J., Spierer, A., Spierer, P. Chromosoma (2006) [Pubmed]
Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome. Reuter, G., Gausz, J., Gyurkovics, H., Friede, B., Bang, R., Spierer, A., Hall, L.M., Spierer, P. Mol. Gen. Genet. (1987) [Pubmed]
Functional dissection of the Drosophila modifier of variegation Su(var)3-7. Jaquet, Y., Delattre, M., Spierer, A., Spierer, P. Development (2002) [Pubmed]

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