High impact information on Sb

• Genes of particular interest include corin- and Stubble-like genes, both of which have a type II transmembrane domain; easter- and snake-like genes, which may fulfil the roles of easter and snake in the Toll pathway; and a masquerade-like gene, potentially involved in enzyme regulation [1].
• Both dominant Sb and recessive sbd mutations affect the organization of microfilament bundles during bristle morphogenesis [2].
• Consistent with the cell-autonomous nature of the Sb-sbd bristle phenotype, a disulfide bond between cysteine residues in the noncatalytic N-terminal fragment and the C-terminal catalytic fragment could tether the protease to the membrane after activation [2].
• Mutations in Sb-sbd are associated with defects in apical cell shape changes critical for the evagination of the leg imaginal disc and with defects in assembly and extension of parallel actin bundles in growing mechanosensory bristles [3].
• We propose a model whereby Sb-sbd helps coordinate proteolytic modification of extracellular matrix attachments with cytoskeletal changes in both legs and bristles [3].

Biological context of Sb

• Leg morphogenesis, but not bristle growth, is sensitive to Sb-sbd overexpression [3].
• The interaction occurs in deficiency heterozygotes using single, wild-type doses of the BR-C, of the Sb-sbd locus, or of both loci [4].
• The sbd gene maps cytogenetically in proximity to the als and sad genes at position 96A of chromosome 3R, suggesting the existence of a nAChR gene cluster in invertebrates [5].

Anatomical context of Sb

• In embryos, sbd and als transcripts are localized in the central nervous system [5].

Other interactions of Sb

• Three neighboring genes interact with the Broad-Complex and the Stubble-stubbloid locus to affect imaginal disc morphogenesis in Drosophila [6].

Analytical, diagnostic and therapeutic context of Sb

• Sequence analyses indicate that the Sb-sbd-encoded protease could activate itself by proteolytic cleavage [2].

References