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Gene Review

Bin1  -  Bicoid interacting protein 1

Drosophila melanogaster

Synonyms: 150001_at, 18 kDa Sin3-associated polypeptide, BcDNA:RE02417, Bicoid-interacting protein 1, Bin 1, ...
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High impact information on Bin1

  • We also provide evidence to suggest that the action of the self-inhibitory domain requires a Drosophila co-factor(s), other than CtBP or dSAP18 [1].
  • The GAGA factor of Drosophila interacts with SAP18, a Sin3-associated polypeptide [2].
  • Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster [3].
  • These sap18 mutant embryos fail to repress hb expression, and show reduced anterior cap expression of the labral determinant cap 'n' collar [3].
  • Drosophila Enhancer of zeste protein interacts with dSAP18 [4].

Biological context of Bin1


Physical interactions of Bin1

  • These results suggest a model in which dSAP18 interacts with Bicoid to silence expression of Bicoid target genes in the anterior tip of the embryo [5].
  • Here we also show that dSAP18 forms a complex with the Drosophila homolog of pinin (dPnn), a protein factor involved in mRNA splicing. dSAP18-dPnn interaction was confirmed in vivo, through co-immunoprecipitation experiments, as well as in vitro, through GST pull-down assays [6].

Other interactions of Bin1

  • Bin1 is similar to a human protein (SAP18) involved in transcription regulation, and Bin3, described in this paper, is similar to a family of protein methyltransferases that modify RNA-binding proteins [7].
  • The first 245 residues of GAGA, including the POZ domain, are necessary and sufficient to bind dSAP18 [2].

Analytical, diagnostic and therapeutic context of Bin1

  • Co-immunoprecipitation experiments provide evidence for in vivo association of E(Z) and dSAP18 [4].
  • Gel filtration analysis of embryo nuclear extracts shows that dSAP18 is present in native protein complexes ranging from approximately 1100 to approximately 450 kDa in molecular mass [4].


  1. The activity of the Drosophila morphogenetic protein Bicoid is inhibited by a domain located outside its homeodomain. Zhao, C., York, A., Yang, F., Forsthoefel, D.J., Dave, V., Fu, D., Zhang, D., Corado, M.S., Small, S., Seeger, M.A., Ma, J. Development (2002) [Pubmed]
  2. The GAGA factor of Drosophila interacts with SAP18, a Sin3-associated polypeptide. Espinás, M.L., Canudas, S., Fanti, L., Pimpinelli, S., Casanova, J., Azorín, F. EMBO Rep. (2000) [Pubmed]
  3. Sap18 is required for the maternal gene bicoid to direct anterior patterning in Drosophila melanogaster. Singh, N., Zhu, W., Hanes, S.D. Dev. Biol. (2005) [Pubmed]
  4. Drosophila Enhancer of zeste protein interacts with dSAP18. Wang, L., Ding, L., Jones, C.A., Jones, R.S. Gene (2002) [Pubmed]
  5. Drosophila SAP18, a member of the Sin3/Rpd3 histone deacetylase complex, interacts with Bicoid and inhibits its activity. Zhu, W., Foehr, M., Jaynes, J.B., Hanes, S.D. Dev. Genes Evol. (2001) [Pubmed]
  6. Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing. Costa, E., Canudas, S., Garcia-Bassets, I., Pérez, S., Fernández, I., Giralt, E., Azorín, F., Espinás, M.L. Chromosome Res. (2006) [Pubmed]
  7. Identification of drosophila bicoid-interacting proteins using a custom two-hybrid selection. Zhu, W., Hanes, S.D. Gene (2000) [Pubmed]
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