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Gene Review

CtBP  -  C-terminal Binding Protein

Drosophila melanogaster

Synonyms: 0256/16, 256/16, BcDNA:GH07572, C-terminal-binding protein, CG7583, ...
 
 
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Disease relevance of CtBP

 

High impact information on CtBP

 

Biological context of CtBP

 

Anatomical context of CtBP

 

Associations of CtBP with chemical compounds

  • Our results also show that repression by TTK69 of GAGA-dependent activation of the eve promoter is not mediated by any of the co-repressors known to interact with TTK69 (dMi2 or C-terminal binding protein) or by trichostatin A-sensitive histone deacetylases [11].
 

Physical interactions of CtBP

  • CtIP, Snail (N-terminal peptide) and Knirps peptides all bind to mammalian CtBP with high affinity (K(i) of 1.04, 1.34 and 0.52 microM, respectively) [7].
  • It has been shown that peptides identical to the CtBP binding site in CtIP and at the N terminus of Snail form a series of beta-turns similar to those seen in AdE1A [7].
  • Here, we present evidence that Giant might also interact with dCtBP [12].
  • The dCtBP binding motif of Hairless is essential for the function of Hairless in vivo [13].
  • A dCtBP consensus binding motif in the C terminus appears to contribute to Ttk69 activity, but it cannot be fully responsible for the function of the C terminus [14].
 

Other interactions of CtBP

  • Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors [15].
  • Finally, we define crucial roles for the adaptor protein Hairless and the co-repressors Groucho and CtBP in conferring repressive activity on Su(H) in the SOP [16].
  • Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression [5].
  • CtBP-dependent activities of the short-range Giant repressor in the Drosophila embryo [12].
  • The Drosophila Knirps protein is a short-range transcriptional repressor that locally inhibits activators by recruiting the CtBP co-repressor [6].
 

Analytical, diagnostic and therapeutic context of CtBP

References

  1. Interaction of short-range repressors with Drosophila CtBP in the embryo. Nibu, Y., Zhang, H., Levine, M. Science (1998) [Pubmed]
  2. Distinct in vivo requirements for establishment versus maintenance of transcriptional repression. Wheeler, J.C., VanderZwan, C., Xu, X., Swantek, D., Tracey, W.D., Gergen, J.P. Nat. Genet. (2002) [Pubmed]
  3. YY1 DNA binding and PcG recruitment requires CtBP. Srinivasan, L., Atchison, M.L. Genes Dev. (2004) [Pubmed]
  4. Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless. Barolo, S., Stone, T., Bang, A.G., Posakony, J.W. Genes Dev. (2002) [Pubmed]
  5. Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. Poortinga, G., Watanabe, M., Parkhurst, S.M. EMBO J. (1998) [Pubmed]
  6. Quantitative contributions of CtBP-dependent and -independent repression activities of Knirps. Struffi, P., Corado, M., Kulkarni, M., Arnosti, D.N. Development (2004) [Pubmed]
  7. Structural determinants outside the PXDLS sequence affect the interaction of adenovirus E1A, C-terminal interacting protein and Drosophila repressors with C-terminal binding protein. Molloy, D.P., Barral, P.M., Bremner, K.H., Gallimore, P.H., Grand, R.J. Biochim. Biophys. Acta (2001) [Pubmed]
  8. The CtBP family: enigmatic and enzymatic transcriptional co-repressors. Turner, J., Crossley, M. Bioessays (2001) [Pubmed]
  9. The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu. Hemavathy, K., Hu, X., Ashraf, S.I., Small, S.J., Ip, Y.T. Dev. Biol. (2004) [Pubmed]
  10. The Snail protein family regulates neuroblast expression of inscuteable and string, genes involved in asymmetry and cell division in Drosophila. Ashraf, S.I., Ip, Y.T. Development (2001) [Pubmed]
  11. Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69. Pagans, S., Piñeyro, D., Kosoy, A., Bernués, J., Azorín, F. J. Biol. Chem. (2004) [Pubmed]
  12. CtBP-dependent activities of the short-range Giant repressor in the Drosophila embryo. Nibu, Y., Levine, M.S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  13. Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila. Morel, V., Lecourtois, M., Massiani, O., Maier, D., Preiss, A., Schweisguth, F. Curr. Biol. (2001) [Pubmed]
  14. The N-terminal BTB/POZ domain and C-terminal sequences are essential for Tramtrack69 to specify cell fate in the developing Drosophila eye. Wen, Y., Nguyen, D., Li, Y., Lai, Z.C. Genetics (2000) [Pubmed]
  15. Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors. Nagel, A.C., Krejci, A., Tenin, G., Bravo-Patiño, A., Bray, S., Maier, D., Preiss, A. Mol. Cell. Biol. (2005) [Pubmed]
  16. Lateral inhibition in proneural clusters: cis-regulatory logic and default repression by Suppressor of Hairless. Castro, B., Barolo, S., Bailey, A.M., Posakony, J.W. Development (2005) [Pubmed]
  17. Solution Structure of the THAP Domain from Caenorhabditis elegans C-terminal Binding Protein (CtBP). Liew, C.K., Crossley, M., Mackay, J.P., Nicholas, H.R. J. Mol. Biol. (2007) [Pubmed]
 
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