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Gene Review

mGluR  -  metabotropic Glutamate Receptor

Drosophila melanogaster

Synonyms: CAA67993.1_Dr, CG11144, DmGlu-A, DmGlu-RA, DmGluA, ...
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Disease relevance of Glu-RA


High impact information on Glu-RA


Biological context of Glu-RA

  • These phenotypes are reminiscent of hyperexcitable mutants, suggesting a role of DmGluRA signaling in the regulation of presynaptic excitability properties [5].
  • In contrast, the Drosophila genome encodes a single functional mGluR (DmGluRA), an ortholog of vertebrate group II mGluRs, greatly expediting the functional characterization of mGluR-mediated signaling in the nervous system [5].
  • Null DmGluRA mutants are completely viable, and all of the basal NMJ synaptic transmission properties are normal [5].
  • We show here that DmGluRA is expressed at the glutamatergic neuromuscular junction (NMJ), localized in periactive zones of presynaptic boutons but excluded from active sites [5].

Anatomical context of Glu-RA


Other interactions of Glu-RA


  1. Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye. Eroglu, C., Cronet, P., Panneels, V., Beaufils, P., Sinning, I. EMBO Rep. (2002) [Pubmed]
  2. Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of fragile X syndrome. McBride, S.M., Choi, C.H., Wang, Y., Liebelt, D., Braunstein, E., Ferreiro, D., Sehgal, A., Siwicki, K.K., Dockendorff, T.C., Nguyen, H.T., McDonald, T.V., Jongens, T.A. Neuron (2005) [Pubmed]
  3. Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts. Eroglu, C., Brugger, B., Wieland, F., Sinning, I. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Use of the exogenous Drosophila octopamine receptor gene to study Gq-coupled receptor-mediated responses in mammalian neurons. Morita, M., Susuki, J., Amino, H., Yoshiki, F., Moizumi, S., Kudo, Y. Neuroscience (2006) [Pubmed]
  5. The Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology. Bogdanik, L., Mohrmann, R., Ramaekers, A., Bockaert, J., Grau, Y., Broadie, K., Parmentier, M.L. J. Neurosci. (2004) [Pubmed]
  6. Distribution of metabotropic glutamate receptor DmGlu-A in Drosophila melanogaster central nervous system. Ramaekers, A., Parmentier, M.L., Lasnier, C., Bockaert, J., Grau, Y. J. Comp. Neurol. (2001) [Pubmed]
  7. DmGluRA, a Drosophila metabotropic glutamate receptor, activates G-protein inwardly rectifying potassium channels in Xenopus oocytes. Raymond, V., Hamon, A., Grau, Y., Lapied, B. Neurosci. Lett. (1999) [Pubmed]
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