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Gene Review:

MICD - MHC class I polypeptide-related sequence D...

Homo sapiens

Synonyms: PERB11.4

Bardales, R.H. et al., Cattley, S.K. et al., Zimmer, N.A. et al.

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Disease relevance of MICD

Conventional hematoxylin and eosin stain showed acute MI (group A, n = 32), equivocal evidence for MICD or early infarction (group B, n = 35), or no abnormal findings (group C, n = 13) [1].

Psychiatry related information on MICD

There is increasing evidence that mildly impaired patients with Alzheimer's disease (AD) may be distinguished from mildly impaired patients with multi-infarct cognitive disorder (MICD) by their degree of semantic memory impairment [2].

High impact information on MICD

The sensitivity and specificity of the in situ apoptosis assay for MICD were confirmed in groups A and C patients [1].
The in situ assay of DNA fragmentation can detect MICD while the histological diagnosis is still inconclusive [1].
Conventional histopathological techniques are of limited utility in the demonstration of myocardial ischemic cell death (MICD) within the first 6 hours of MI [1].
By comparing the sequences of primates (chimpanzee, gorilla, gibbon, orang-utan, pygmy chimpanzee, Patas monkey, Aethiops and baboon) we conclude that the gorilla has a copy of PERB11.1, whereas the baboon and Patas possess MICD (PERB11.4) and/or MICE (PERB11.5) rather than MICA (PERB11.1) [3].

Biological context of MICD

In this group, 34/35 cases (97%) showed focal or diffuse nuclear positivity of varying degrees for apoptosis, confirming the presence of MICD [1].

References

In situ apoptosis assay for the detection of early acute myocardial infarction. Bardales, R.H., Hailey, L.S., Xie, S.S., Schaefer, R.F., Hsu, S.M. Am. J. Pathol. (1996) [Pubmed]
Comparative performance of mildly impaired patients with Alzheimer's disease and multiple cerebral infarctions on tests of memory and functional capacity. Zimmer, N.A., Hayden, S., Deidan, C., Loewenstein, D.A. International psychogeriatrics / IPA. (1994) [Pubmed]
Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4. Cattley, S.K., Longman, N., Dawkins, R.L., Gaudieri, S., Kulski, J.K., Leelayuwat, C. Eur. J. Immunogenet. (1999) [Pubmed]

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