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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Pan paniscus

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Disease relevance of Pan paniscus


High impact information on Pan paniscus

  • We also found three shared human/pygmy chimpanzee polymorphisms, all involving CpG dinucleotides, and two shared human/gorilla polymorphisms, one involving a CpG dinucleotide [2].
  • Some pygmy chimpanzees (also called Bonobos) give much simpler patterns of hybridization on Southern blotting with killer cell immunoglobulin-like receptor (KIR) cDNA probes than do either humans or common chimpanzees [3].
  • Thus, the lineage leading to modern humans suffered a mutation sometime after the common ancestor with the chimpanzee and bonobo, potentially affecting recognition by a variety of endogenous and exogenous sialic acid-binding lectins [4].
  • To investigate the mechanisms of HLA-B evolution we have compared the sequences of 19 HLA-B homologues from chimpanzees and bonobos to 65 HLA-B sequences [5].
  • To understand the nature and pattern of variation and linkage disequilibrium comprising this history, we present a study of approximately 31 kb spanning an approximately 70 kb region of FMR1, sequenced in a sample of 20 humans (worldwide sample) and four great apes (chimp, bonobo, and gorilla) [6].

Biological context of Pan paniscus


Anatomical context of Pan paniscus

  • An inverted and a satellited Y chromosome detected in peripheral blood lymphocytes of a chimpanzee and a pygmy chimpanzee, respectively, were characterized cytogenetically by various banding techniques [10].

Associations of Pan paniscus with chemical compounds


Gene context of Pan paniscus


  1. A HERV-K provirus in chimpanzees, bonobos and gorillas, but not humans. Barbulescu, M., Turner, G., Su, M., Kim, R., Jensen-Seaman, M.I., Deinard, A.S., Kidd, K.K., Lenz, J. Curr. Biol. (2001) [Pubmed]
  2. Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Hacia, J.G., Fan, J.B., Ryder, O., Jin, L., Edgemon, K., Ghandour, G., Mayer, R.A., Sun, B., Hsie, L., Robbins, C.M., Brody, L.C., Wang, D., Lander, E.S., Lipshutz, R., Fodor, S.P., Collins, F.S. Nat. Genet. (1999) [Pubmed]
  3. Short KIR haplotypes in pygmy chimpanzee (Bonobo) resemble the conserved framework of diverse human KIR haplotypes. Rajalingam, R., Hong, M., Adams, E.J., Shum, B.P., Guethlein, L.A., Parham, P. J. Exp. Med. (2001) [Pubmed]
  4. A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Chou, H.H., Takematsu, H., Diaz, S., Iber, J., Nickerson, E., Wright, K.L., Muchmore, E.A., Nelson, D.L., Warren, S.T., Varki, A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. A uniquely high level of recombination at the HLA-B locus. McAdam, S.N., Boyson, J.E., Liu, X., Garber, T.L., Hughes, A.L., Bontrop, R.E., Watkins, D.I. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  6. Sequence variation within the fragile X locus. Mathews, D.J., Kashuk, C., Brightwell, G., Eichler, E.E., Chakravarti, A. Genome Res. (2001) [Pubmed]
  7. Application of urinary and fecal steroid measurements for monitoring ovarian function and pregnancy in the bonobo (Pan paniscus) and evaluation of perineal swelling patterns in relation to endocrine events. Heistermann, M., Möhle, U., Vervaecke, H., van Elsacker, L., Hodges, J.K. Biol. Reprod. (1996) [Pubmed]
  8. Y-chromosome analysis confirms highly sex-biased dispersal and suggests a low male effective population size in bonobos (Pan paniscus). Eriksson, J., Siedel, H., Lukas, D., Kayser, M., Erler, A., Hashimoto, C., Hohmann, G., Boesch, C., Vigilant, L. Mol. Ecol. (2006) [Pubmed]
  9. High-resolution fluorescence in situ hybridization of RBM- and TSPY-related cosmids on released Y chromatin in humans and pygmy chimpanzees. Conrad, C., Hierl, T., Gläser, B., Taylor, K., Zeitler, S., Chandley, A.C., Schempp, W. Chromosome Res. (1996) [Pubmed]
  10. Homoeologic aberrations in human and chimpanzee Y chromosomes: inverted and satellited Y chromosomes. Weber, B., Walz, L., Schmid, M., Schempp, W. Cytogenet. Cell Genet. (1988) [Pubmed]
  11. Pattern and timing of evolutionary divergences among hominoids based on analyses of complete mtDNAs. Arnason, U., Gullberg, A., Janke, A., Xu, X. J. Mol. Evol. (1996) [Pubmed]
  12. Comparative urinary androstanes in the great apes. Hagey, L.R., Czekala, N.M. Gen. Comp. Endocrinol. (2003) [Pubmed]
  13. Comparative study of urinary reproductive hormones in great apes. Shimizu, K., Udono, T., Tanaka, C., Narushima, E., Yoshihara, M., Takeda, M., Tanahashi, A., van Elsackar, L., Hayashi, M., Takenaka, O. Primates (2003) [Pubmed]
  14. Mitochondrial COII sequences and modern human origins. Ruvolo, M., Zehr, S., von Dornum, M., Pan, D., Chang, B., Lin, J. Mol. Biol. Evol. (1993) [Pubmed]
  15. High polymorphism at the human melanocortin 1 receptor locus. Rana, B.K., Hewett-Emmett, D., Jin, L., Chang, B.H., Sambuughin, N., Lin, M., Watkins, S., Bamshad, M., Jorde, L.B., Ramsay, M., Jenkins, T., Li, W.H. Genetics (1999) [Pubmed]
  16. Chimpanzee MHC class I A locus alleles are related to only one of the six families of human A locus alleles. McAdam, S.N., Boyson, J.E., Liu, X., Garber, T.L., Hughes, A.L., Bontrop, R.E., Watkins, D.I. J. Immunol. (1995) [Pubmed]
  17. MHC-F DNA sequences in bonobo, gorilla and orangutan. Rojo, R., Castro, M.J., Martinez-Laso, J., Serrano-Vela, J.I., Morales, P., Moscoso, J., Zamora, J., Arnaiz-Villena, A. Tissue Antigens (2005) [Pubmed]
  18. Interspecific variation at the Y-linked RPS4Y locus in hominoids: implications for phylogeny. Samollow, P.B., Cherry, L.M., Witte, S.M., Rogers, J. Am. J. Phys. Anthropol. (1996) [Pubmed]
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