Disease relevance of Erythrocebus patas

• However, patas monkeys infected with Coxsackie virus B4 or treated first with a subdiabetogenic dose of streptozocin and then infected sequentially with Coxsackie viruses B4 and B3 showed transient elevation of glucose tolerance tests, depressed insulin secretion, and glucose in the urine [1].
• Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine plus lamivudine [2].
• Pregnant patas monkeys were given a daily dose of 40 mg AZT (86% of the human daily dose, based on body weight), for the last 10 weeks (50%) of gestation, and a daily dose of 24 mg 3TC (84% of the human daily dose, based on body weight) for the last 4 weeks of gestation [2].
• Pathology of gestational choriocarcinoma induced in patas monkeys by ethylnitrosourea given during pregnancy [3].

High impact information on Erythrocebus patas

• Using patas monkeys and a multiple schedule with repeated acquisition and performance of chain responses, we report that IMD administration for 17 days antagonized without showing tolerance ALP-induced disruption of acquisition [4].
• We conclude that IDRA 21, a chemically unrelated pharmacological congener of aniracetam, improves learning deficit induced in patas monkeys by the increase of GABAergic tone elicited by alprazolam [5].
• To test primate fetal susceptibility to formation of cancer initiation-related DNA adducts from nitrosamines, pregnant patas monkeys were given 1.0 or 0.1 mg/kg N-nitrosodimethylamine [6].
• O6-methylguanine DNA adduct formation and modulation by ethanol in placenta and fetal tissues after exposure of pregnant patas monkeys to N-nitrosodimethylamine [6].
• Reduced blood clearance and increased urinary excretion of N-nitrosodimethylamine in patas monkeys exposed to ethanol or isopropyl alcohol [7].

Chemical compound and disease context of Erythrocebus patas

• This study was designed to investigate fetal mitochondrial toxicity in Erythrocebus patas monkeys exposed in utero to zidovudine (AZT) and lamivudine (3TC), and taken at term [2].
• STUDY DESIGN/METHODS: Three Erythrocebus patas (patas) monkeys were given 3 mg d4T orally twice daily (total 6 mg d4T), or approximately 1.2 mg d4T/kg body weight per day, for 78 days and compared with 3 unexposed animals [8].

Biological context of Erythrocebus patas

• Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey [9].
• Transplacental cisplatin exposure induces persistent fetal mitochondrial and genomic DNA damage in patas monkeys [10].
• 1. Studies on absorption, excretion and biotransformation of the antihypertensive agent indoramin (3-[2-(4-benzamidopiperidino)ethyl]indole hydrochloride) have been carried out in patas monkeys [11].
• Antibody response of patas monkeys to experimental infection with Delta herpesvirus [12].

Anatomical context of Erythrocebus patas

• Xenoantisera to B cell antigens inhibited the mixed lymphocyte reaction, but did not affect the mitogenic activity of phytohemagglutinin or the functional properties of C3 receptors, monkey red blood cell receptors, or T cell receptors [13].
• Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes [14].

Associations of Erythrocebus patas with chemical compounds

• The patas monkeys had naturally occurring atherosclerosis that was greatly accelerated by feeding a diet containing cholesterol [15].
• In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas [16].
• Metabolism of NNN to norcotinine and its derivatives was far more prevalent in the patas monkey than in the rat [9].
• Vaccination of patas monkeys experimentally infected with Schistosoma haematobium using a recombinant glutathione S-transferase cloned from S. mansoni [17].
• As an extension of previous research on repeated acquisition, a new baseline was developed to assess the effects of phencyclidine on retention in patas monkeys [18].

Gene context of Erythrocebus patas

• However, high concentrations of polyclonal antiserum directed against rat CYP2B inhibited all three activities in PB-induced patas monkeys [19].
• An homologous radioimmunoassay for human serum prolactin was validated to measure serum prolactin in 10 mangabey and 7 patas monkeys [20].
• Patas monkeys were studied for 2 years on three dietary regimes: (1) commercial chow (control diet); (2) semipurified diet plus lard (fat-fed); and (3) semipurified diet plus lard and cholesterol (cholesterol-fed) [21].
• Immunoblot analysis demonstrated that the P450 2A level in the individual patas monkey liver microsomal sample was 6-fold greater than in an individual human liver microsomal sample [14].
• Patas monkey HDL, equivalent to human HDL, were protein and phospholipid rich and ranged in size from 70 to 100 A in diameter [22].

Analytical, diagnostic and therapeutic context of Erythrocebus patas

• The effects of a single intramuscular atropine injection (0.03 mg.kg-1) and a chronic oral pyridostigmine treatment (0.4 mg.kg-1, 3 times/day over a period of 7 d) on the thermoregulatory effector responses of unanesthetized patas monkeys were investigated using indirect calorimetry [23].

References