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Gene Review

MICA  -  MHC class I polypeptide-related sequence A

Homo sapiens

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Disease relevance of MICA

 

High impact information on MICA

  • Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects [6].
  • Expression of a Truncated Cystic Fibrosis Transmembrane Conductance Regulator with an AAV5-pseudotyped Vector in Primates [7].
  • METHODS: Truncated soluble FGF-R1alpha(IIIc) or neutralizing antibodies to FGF-1 or FGF-2 were injected intraperitoneally into 3-d-old rats [8].
  • HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan [9].
  • Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin [10].
 

Biological context of MICA

  • Diversity of MICA (PERB11.1) and HLA haplotypes in Northeastern Thais [11].
  • MICA or PERB11.1 is a polymorphic major histocompatibility complex (MHC) class I-related gene located 46 kb centromeric of the HLA-B gene in the HLA class I region [11].
  • Intralocus and interlocus differences between PERB11.1 and PERB11.2 include: (1) several nucleotide substitutions leading to amino acid changes; (2) presence and absence of potential glycosylation sites; (3) insertions and deletions leading to a frame shift resulting in diversity at the amino acid level and an early termination signal [12].
  • Usage of PCR, reverse transcriptase (RT)-PCR, Southern blot, primary sequence analyses of the 18S rDNA gene, and secondary structure analyses of the 5.8S rRNA showed that one of the operons encodes rDNA pseudogenes in a low copy-number (Truncated), whereas the second operon encodes an expressed rRNA (Functional) [13].
  • The amino acid sequences of PERB11.1 and PERB11.2 as well as those of other related molecules were analysed and compared [14].
 

Anatomical context of MICA

 

Associations of MICA with chemical compounds

 

Other interactions of MICA

  • Coevolution of HLA-B and PERB11.1 (MICA): significance of independent triplet expansion within the transmembrane region of PERB11.1 (MICA) [24].
  • By comparing the sequences of primates (chimpanzee, gorilla, gibbon, orang-utan, pygmy chimpanzee, Patas monkey, Aethiops and baboon) we conclude that the gorilla has a copy of PERB11.1, whereas the baboon and Patas possess MICD (PERB11.4) and/or MICE (PERB11.5) rather than MICA (PERB11.1) [25].
  • There are at least five copies of MIC (PERB11) in humans, but MICA (PERB11.1) appears to have been deleted from the chimpanzee [25].
  • METHODS: Truncated and sequence-modified fluorescent-labeled hCT-derived peptides were synthesized through Fmoc chemistry [17].
 

Analytical, diagnostic and therapeutic context of MICA

References

  1. PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis. Tay, G.K., Hui, J., Gaudieri, S., Schmitt-Egenolf, M., Martinez, O.P., Leelayuwat, C., Williamson, J.F., Eiermann, T.H., Dawkins, R.L. Clin. Exp. Immunol. (2000) [Pubmed]
  2. Effects of genetic blockade of the insulin-like growth factor receptor in human colon cancer cell lines. Adachi, Y., Lee, C.T., Coffee, K., Yamagata, N., Ohm, J.E., Park, K.H., Dikov, M.M., Nadaf, S.R., Arteaga, C.L., Carbone, D.P. Gastroenterology (2002) [Pubmed]
  3. Characterization of the B Cell Epitopes Associated with a Truncated Form of Pseudomonas Exotoxin (PE38) Used to Make Immunotoxins for the Treatment of Cancer Patients. Onda, M., Nagata, S., Fitzgerald, D.J., Beers, R., Fisher, R.J., Vincent, J.J., Lee, B., Nakamura, M., Hwang, J., Kreitman, R.J., Hassan, R., Pastan, I. J. Immunol. (2006) [Pubmed]
  4. A Truncated Alternative Spliced Isoform of Human Desmoglein 1 Contains a Specific T Cell Epitope Binding to the Pemphigus Foliaceus-Associated HLA Class II DRbeta1*0102 Molecule. Mouquet, H., Farci, S., Joly, P., Maill??re, B., Leblond, J., Drouot, L., Leprince, J., Tonon, M.C., Loiseau, P., Charron, D., Tron, F., Gilbert, D. J. Immunol. (2006) [Pubmed]
  5. Oncolytic Viruses Derived from the gamma34.5-Deleted Herpes Simplex Virus Recombinant R3616 Encode a Truncated UL3 Protein. Dambach, M.J., Trecki, J., Martin, N., Markovitz, N.S. Mol. Ther. (2006) [Pubmed]
  6. Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects. Maegawa, H., McClain, D.A., Freidenberg, G., Olefsky, J.M., Napier, M., Lipari, T., Dull, T.J., Lee, J., Ullrich, A. J. Biol. Chem. (1988) [Pubmed]
  7. Expression of a Truncated Cystic Fibrosis Transmembrane Conductance Regulator with an AAV5-pseudotyped Vector in Primates. Fischer, A.C., Smith, C.I., Cebotaru, L., Zhang, X., Askin, F.B., Wright, J., Guggino, S.E., Adams, R.J., Flotte, T., Guggino, W.B. Mol. Ther. (2007) [Pubmed]
  8. Fibroblast growth factor-2 and receptor-1alpha(IIIc) regulate postnatal rat lung cell apoptosis. Yi, M., Belcastro, R., Shek, S., Luo, D., Post, M., Tanswell, A.K. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
  9. HER2-Specific T-Cell Immune Responses in Patients Vaccinated with Truncated HER2 Protein Complexed with Nanogels of Cholesteryl Pullulan. Kitano, S., Kageyama, S., Nagata, Y., Miyahara, Y., Hiasa, A., Naota, H., Okumura, S., Imai, H., Shiraishi, T., Masuya, M., Nishikawa, M., Sunamoto, J., Akiyoshi, K., Kanematsu, T., Scott, A.M., Murphy, R., Hoffman, E.W., Old, L.J., Shiku, H. Clin. Cancer Res. (2006) [Pubmed]
  10. Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin. Dabydeen, D.A., Burnett, J.C., Bai, R., Verdier-Pinard, P., Hickford, S.J., Pettit, G.R., Blunt, J.W., Munro, M.H., Gussio, R., Hamel, E. Mol. Pharmacol. (2006) [Pubmed]
  11. Diversity of MICA (PERB11.1) and HLA haplotypes in Northeastern Thais. Romphruk, A.V., Naruse, T.K., Romphruk, A., Kawata, H., Puapairoj, C., Kulski, J.K., Leelayuwat, C., Inoko, H. Tissue Antigens (2001) [Pubmed]
  12. Allelic and interlocus comparison of the PERB11 multigene family in the MHC. Gaudieri, S., Leelayuwat, C., Townend, D.C., Mullberg, J., Cosman, D., Dawkins, R.L. Immunogenetics (1997) [Pubmed]
  13. Extensive ribosomal DNA genic variation in the columnar cactus Lophocereus. Hartmann, S., Nason, J.D., Bhattacharya, D. J. Mol. Evol. (2001) [Pubmed]
  14. Antibody reactivity profiles following immunization with diverse peptides of the PERB11 (MIC) family. Leelayuwat, C., Hollingsworth, P., Pummer, S., Lertmemongkolchai, G., Thom, G., Mullberg, J., Witt, C., Kaufman, J., Degli-Esposti, M.A., Cosman, D., Dawkins, R. Clin. Exp. Immunol. (1996) [Pubmed]
  15. Truncated E-cadherin potentiates cell death in prostate epithelial cells. Rios-Doria, J., Day, M.L. Prostate (2005) [Pubmed]
  16. FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance. McIver, B., Grebe, S.K., Wang, L., Hay, I.D., Yokomizo, A., Liu, W., Goellner, J.R., Grant, C.S., Smith, D.I., Eberhardt, N.L. Clin. Endocrinol. (Oxf) (2000) [Pubmed]
  17. Cellular internalization of human calcitonin derived peptides in MDCK monolayers: a comparative study with Tat(47-57) and penetratin(43-58). Tréhin, R., Krauss, U., Muff, R., Meinecke, M., Beck-Sickinger, A.G., Merkle, H.P. Pharm. Res. (2004) [Pubmed]
  18. First metatarsophalangeal joint arthrodesis with the Truncated Cone Reamer System. Shim, G.S., Pikscher, I., Frankel, N. The Journal of foot surgery. (1992) [Pubmed]
  19. Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine. He, W., Huang, F.C., Gavai, A., Chan, W.K., Amato, G., Yu, K.T., Zilberstein, A. Bioorg. Med. Chem. Lett. (1998) [Pubmed]
  20. Total syntheses of bioactive oxidized ethanolamine phospholipids. Gugiu, B.G., Salomon, R.G. Org. Lett. (2003) [Pubmed]
  21. ToF-SIMS Investigation of Octadecylphosphonic Acid Monolayers on a Mica Substrate. Francis, J.T., Nie, H.Y., McIntyre, N.S., Briggs, D. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  22. Synthesis and anti-HIV activity of 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (TBO) derivatives. Truncated 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2( 1H)-on es (TIBO) analogues. Breslin, H.J., Kukla, M.J., Kromis, T., Cullis, H., De Knaep, F., Pauwels, R., Andries, K., De Clercq, E., Janssen, M.A., Janssen, P.A. Bioorg. Med. Chem. (1999) [Pubmed]
  23. Nonparametric Estimation of Sojourn Time Distributions for Truncated Serial Event Data-a Weight-adjusted Approach. Chang, S.H., Tzeng, S.J. Lifetime data analysis. (2006) [Pubmed]
  24. Coevolution of HLA-B and PERB11.1 (MICA): significance of independent triplet expansion within the transmembrane region of PERB11.1 (MICA). Dunn, D.S., Williamson, J.F., Cattley, S.K., Tay, G.K., Gaudieri, S., Leelayuwat, C., Dawkins, R.L. J. Mol. Evol. (2000) [Pubmed]
  25. Phylogenetic analysis of primate MIC (PERB11) sequences suggests that the representation of the gene family differs in different primates: comparison of MIC (PERB11) and C4. Cattley, S.K., Longman, N., Dawkins, R.L., Gaudieri, S., Kulski, J.K., Leelayuwat, C. Eur. J. Immunogenet. (1999) [Pubmed]
  26. Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine. Richt, J.A., Lekcharoensuk, P., Lager, K.M., Vincent, A.L., Loiacono, C.M., Janke, B.H., Wu, W.H., Yoon, K.J., Webby, R.J., Sol??rzano, A., Garc??a-Sastre, A. J. Virol. (2006) [Pubmed]
 
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